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121. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/appendicitis/research-protocol
     December 01, 2019 - We will use existing systematic reviews to identify single index test studies with test performance outcomes … Have examined test performance outcomes. … Test characteristics include aspects specific to each diagnostic test of interest (e.g., the use and … Of note, studies evaluating the test performance of (the same) single index test will be synthesized … Methods Guide for Medical Test Reviews.

122. What are the indications for inserting tympanostomy tubes how many Otitis Media w Effusion or Acute Otitis Media episodes in what time frameShould clinicians obtain a hearing test prior to inserting tympanostomy tubesShould clinicians… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-are-the-indications-for-inserting-tympanostomy-tubes-how-many-otitis-media-w-effusion-or-acute-otitis-media-episodes-in-what-time-frameshould-clinicians-obtain-a-hearing-test-prior-to-inserting-tympanostomy-tubesshould-
     November 01, 2017 - Media w Effusion or Acute Otitis Media episodes in what time frameShould clinicians obtain a hearing test … Media w Effusion or Acute Otitis Media episodes in what time frameShould clinicians obtain a hearing test … Briefly describe a specific question, or set of related questions, about a health care test … Media w Effusion or Acute Otitis Media episodes in what time frameShould clinicians obtain a hearing test … Media w Effusion or Acute Otitis Media episodes in what time frameShould clinicians obtain a hearing test

123. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
     January 01, 2009 - because of this test?” … Most models start with a Phase I, which consists of test development. … During this phase the test has to meet prespecified technical requirements. … establish how well the test is able to identify patients with the target condition. … How to evaluate a diagnostic marker test.

124. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
     January 01, 2009 - because of this test?” … Most models start with a Phase I, which consists of test development. … During this phase the test has to meet prespecified technical requirements. … establish how well the test is able to identify patients with the target condition. … How to evaluate a diagnostic marker test.

125. Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions: An Update to the 2009 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-biopsy-update/research
     December 01, 2019 - We found one new study investigating the test performance of open biopsy. … However, evidence on the test performance of magnetic resonance imaging (MRI)-guided biopsy (6 studies … Test performance did not differ between women at average and high baseline risk of cancer, but results … Test performance of automated and vacuum-assisted devices (when using the same imaging guidance) was … The strength of evidence on the comparative test performance of automated and vacuum-assisted devices

126. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
     September 30, 2014 - A genetic test may reach the market as a commercially distributed test kit approved or cleared by the … test kits include all reagents and instructions needed to complete the test procedure and interpret … Data Form for Each Test Identified Data Items Data Collected Data Source Test Describe the full name … The Landscape of Genetic Testing for Diagnosing DDs Clinical Test Available Test Provider/ Targeted … If a test has utility, it means that the results of the test can be used to seek effective treatment

127. Blood-based Tests for Multiple Cancer Screening: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cell-free-dna/protocol
     July 01, 2024 - KQ 3: Studies that provide data related to test accuracy; both prediagnostic test performance and diagnostic … test performance designs are eligible. … of test Note: succinctly summarize the author’s description of test including key steps in the assay … test Note: succinctly summarize the author's description of test including key steps in the assay and … and negative test)   N False Positives (participants without cancer and positive test)   Author-reported

128. Breast-Biopsy-Update Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
     September 01, 2014 - (e.g., blinding of index test assessors to reference standard results), reference standard test (e.g … Test Performance of Open Surgical Biopsy Published information on the test performance of open surgical … (i.e., a test without measurement error). … assessors to the index test results. … Test Performance and Comparative Test Performance Among women at average risk of cancer, core needle

129. Testing a Machine Learning Tool for Facilitating Living Systematic Reviews of Chronic Pain Treatments | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/machine-learning-tool/methods-report
     August 01, 2021 - Contents Purpose of Project To develop and test … text word-only search strategies without MEDLINE ® indexing for three chronic pain living reviews, test … This project had three stages: develop optimized search strategies (Stage 1), test machine learning classifier … on optimized searches (Stage 2), and test machine learning classifier on monthly update searches (Stage

130. Diagnosis of Celiac Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/celiac-disease/research-protocol
     December 01, 2020 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were … the index test results interpreted without knowledge of the reference standard? … (Yes/No/Unclear) Could the conduct or interpretation of the index test have introduced bias? … Methods to detect publication bias for medical test studies are not robust. … Methods Guide for Medical Test Reviews. AHRQ. 2012. McNeish AS, Harms HK, Rey J, et al.

131. Proposals for a Phased Evaluation of Medical Tests | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/medical-tests-proposals/research
     December 01, 1969 - because of this test?” … Most models start with a Phase I, which consists of test development. … During this phase the test has to meet prespecified technical requirements. … How to evaluate a diagnostic marker test. … Interpreting diagnostic test accuracy studies. Semin Hematol 2008;45:189-195.

132. Version-3-Immunity-After-Covid-19-Appendix-Table-B-1 (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
     January 24, 2022 - N (%) Male Sex/Gender, N (%) Comorbidities, N (%) Assay Type Assay Brand Definition of a positive test … NR Vaccinated and unvaccinated adults with a positive RT-PCR test result before December 2, 2020. … Pts with initial positive test Mean: 50.5 (21.0) Pts with initial negative test Min: 52.8 (21.4) 237,210 … Ab+ at baseline with PCR+ during follow-up Positive serological test or PCR test upon recruitment PCR … Test type NR.

133. Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive, Web-Based Presentation and Discussion of Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/linking-evidence/methods-report
     January 01, 2020 - Evidence Reports Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … The goal of the Clinical Operations Evidence Review cyberseminar pilot project was to develop and test … Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive, Web-Based … Research Report: Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test

134. Cancer-Pancreas Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
     August 09, 2013 - under which to order a second test and which test to order; and if a test is ordered, what is its influence … Test Criteria 1. … specificity of the test. … indicates that test A is more accurate, (2) evidence indicates that test B is more accuracy, or 3) … statistical test.

135. Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests
     March 01, 2021 - SHARE: Methods Guide for Medical Test … originally created December 2020 Internet Citation: Methods Guide for Medical Test

136. Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
     January 15, 2015 - The first step is assessing pre-test likelihood that the patient has CAD. … for test-positive people. … Harms related to both the initial test as well as subsequent testing will be evaluated. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EC017. … positive and are treated with those who test negative and are not treated.

137. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease: Future Research Needs (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia_research.pdf
     January 01, 2013 - results, and differences in test performance pose a dilemma regarding the most appropriate test to … results, and differences in test performance pose a dilemma regarding the most appropriate test to … Low / Insufficient (depending on the test comparisons, study populations, or test performance … For example, to evaluate the test performance of a diagnostic test, it is ideal to recruit consecutive … In contrast, to evaluate the test performance of a monitoring test, it is ideal to recruit consecutive

138. Addressing Challenges in Genetic Test Evaluation: Evaluation Frameworks and Assessment of Analytic Validity | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/genetic-tests-validity-rating-evaluation/research
     November 01, 2017 - Home Evidence Reports Addressing Challenges in Genetic Test … SHARE: Addressing Challenges in Genetic Test … Future effort is required to test these frameworks, validate the instrument, and fill the gaps in evidence … Project Timeline Addressing Challenges in Genetic Test Evaluation: Evaluation Frameworks and Assessment … Internet Citation: Research Report: Addressing Challenges in Genetic Test

139. Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/liver-cancer/research
     December 01, 2019 - The purpose of this review is to compare the effectiveness of imaging techniques for HCC on test performance … the reference standard used and study, patient, tumor, and technical characteristics on estimates of test … A total of 281 studies were included, 274 of which evaluated test performance. … modalities have relatively high sensitivity and specificity for diagnosis or staging of HCC, although test … Although there are some potential differences in test performance between different imaging modalities

140. Editorial. Methods Guide for Authors of Systematic Reviews of Medical Tests: A Collaboration Between the Agency for Healthcare Research and Quality (AHRQ) and the Journal of General Internal Medicine | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guide-editorial/methods
     December 01, 2019 - For example, the principal “outcome” of a study of a medical test is commonly a proxy or intermediate … The most common outcome in an evaluation of this test is the accuracy of the test in identifying clinically … Clinicians, while interested in this proxy outcome, would find more value in the ability of the test … Cochrane Diagnostic Test Accuracy Working Group. Handbook for DTA reviews. … Editorial printed in Methods Guide for Medical Test Reviews (AHRQ Publication No. 12-EHC017).