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1. Prostate-Cancer-Test Executive (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
   April 01, 2013 - 11 Also, issues such as who to test, when to test and retest, and the most effective clinical tPSA … The intended use of the test is to inform decisionmaking about repeat biopsy. … An AUC of 1.0 indicates a perfect test, and an AUC of 0.5 indicates a worthless test. 4 matching … was preserved by computing differences between PCA3 test results and comparator test results within … The effect of even a great test is limited if uptake is low.

2. Test-Performance-Metrics Appendixes (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
   January 01, 2005 - A-1 Appendix: Test Performance Metrics The basic definitions of test performance are based upon … It expresses the ability of a medical test to maximize true positives. … It expresses the ability of a test to minimize false positives. … If the threshold (cutpoint) for test positive is set higher—say when the test provides a continuously … How to use an article about a diagnostic test. B.

3. Appendix: Methods Guide for Medical Test Reviews: Test Performance Metrics | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/test-performance-metrics
   March 01, 2021 - SHARE: Appendix: Methods Guide for Medical Test … Reviews: Test Performance Metrics Project Timeline May 21, 2012 … created December 2020 Internet Citation: Appendix: Methods Guide for Medical Test … Reviews: Test Performance Metrics. … https://effectivehealthcare.ahrq.gov/products/test-performance-metrics  

4. Appendix: Test Performance Metrics | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/test-performance-metrics/appendixes
   December 01, 2019 - “true disease status” and the test results (Appendix Table). … It expresses the ability of a test to minimize false positives. … If the threshold (cutpoint) for test positive is set higher—say when the test provides a continuously … How to use an article about a diagnostic test. B. … Project Timeline Appendix: Methods Guide for Medical Test Reviews: Test Performance Metrics May

5. Prostate-Cancer-Test Research-Protocol (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
   October 14, 2011 - Was the reference standard independent of the index test (i.e., the index test did not form part of … Was the execution of the index test described in sufficient detail to permit replication of the test … when the test is used in practice? … For the pooled results, was a test done to assess homogeneity (i.e., Chi-squared test, I2)? … but decrease test specificity.

6. Methods Guide for Medical Test Reviews (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
   July 01, 2012 - Methods Guide for Medical Test Reviews 8-1 Chapter 8 Meta-Analysis of Test Performance When … Introduction The Methods Guide to Medical Test Reviews (also referred to as the Medical Test Methods … This chapter of the Medical Test Methods Guide focuses on choosing strategies for meta- analysis of test … questions driving the evidence synthesis (e.g., “Is this test alone or in combination with a test-and-treat … medical test evidence focuses on summarizing test performance data; thus their meta-analysis was chosen

7. Methods Guide for Medical Test Reviews (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
   July 01, 2012 - in Medical Test Studies P. … Variation in test technology When the characteristics of a medical test change over time as a result … of an index test. … the sensitivity and specificity of the test may lead to over-optimistic measures of test performance … Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index

8. Using the Principles of Randomized Controlled Trial Design to Guide Test Evaluation | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/rtc-design-principles/research
   January 01, 2019 - replacement for the existing test, an add-on test after the existing test, or as a triage test before … test. … test? … The add-on test Difference in test-treatment pathway using add-on test shown in black TP= true … The triage test Difference in test-treatment pathway using triage test shown in black TN = true

9. Chapter 3: Choosing the Important Outcomes for a Systematic Review of a Medical Test | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-outcomes/methods
   October 01, 2019 - Screening Test Diagnostic Test Prognostic Test Clinical management + +++ +++ … , a diagnostic test, and a prognostic test. … Costs of the test. … Direct test effects. The test under consideration is a radiographic test. … Costs of the test.

10. Chapter 1: Introduction to the Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-introduction/methods
    December 01, 2019 - This Methods Guide for Medical Test Reviews (referred to hereafter as the Medical Test Methods Guide … Development of the Medical Test Methods Guide In developing this Medical Test Methods Guide , we sought … Indeed, test performance characteristics have been treated as sufficient criteria of test value (i.e. … prognosis category Diagnostic accuracy efficacy Clinical validity Test accuracy Test performance … C Comparator Comparator test-and-treat strategy Desciption of comparator test performance

11. Chapter 9: Options for Summarizing Medical Test Performance in the Absence of a “Gold Standard” | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-performance/methods
    December 01, 2019 - with a reference test. … Perhaps the simplest case of test performance evaluation includes an "index test" and a reference test … (+) Reference Test (-) Index Test (+)     Index Test (-)     We now … One explores how well one test agrees with the other test(s), and perhaps asks if one test can be used … Comparison of a screening test and a reference test in epidemiologic studies. II.

12. Chapter 5: Assessing Risk of Bias as a Domain of Quality in Medical Test Studies | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-bias/methods
    December 01, 2019 - Test Protocol: Materials and Methods Variation in test execution A sufficient description of … Variation in test technology When the characteristics of a medical test change over time as a result … of an index test. … the sensitivity and specificity of the test may lead to over-optimistic measures of test performance … Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the

13. Chapter 6: Assessing Applicability of Medical Test Studies in Systematic Reviews | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-applicability/methods
    December 01, 2019 - test (i.e., as a replacement), but in reality the test is proposed to be used as a triage test to guide … Alternate or “usual” test used in the studies. … Exclude a priori if test results cannot be mapped to disease status (i.e., 2x2 or other test performance … Placement of test in the sequence of care (e.g. relationship of test to treatment or follow-on management … Routine Preventive Care Over Time Routine use of a medical test as a screening test might be considered

14. Training Modules for the Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests/slides
    December 01, 2019 - Evidence Reports Training Modules for the Methods Guide for Medical Test … SHARE: Training Modules for the Methods Guide for Medical Test … Modules* Introduction to the Methods Guide for Medical Test Reviews (PPT; 1.4 MB) Developing the … Reviews of Medical Tests (PPT; 2.0 MB) Assessing Risk of Bias as a Domain of Quality in Medical Test … Studies (PPT; 2.1 MB) Assessing Applicability of Medical Test Studies in Systematic Reviews (PPT

15. Chapter 8: Meta-Analysis of Test Performance When There Is a “Gold Standard” | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-metaanalysis/methods
    December 01, 2019 - Introduction The Methods Guide to Medical Test Reviews (also referred to as the Medical Test Methods … test “accuracy,” or more preferably, test performance. … questions driving the evidence synthesis (e.g., "Is this test alone or in combination with a test-and-treat … medical test evidence focuses on summarizing test performance data; thus their meta-analysis was chosen … Cochrane Diagnostic Test Accuracy Working Group.

16. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-test
    March 01, 2021 - https://effectivehealthcare.ahrq.gov/products/prostate-cancer-test  

17. Chapter 12: Systematic Review of Prognostic Tests | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-prognostic/methods
    December 01, 2019 - Therefore, the “reference test” for a prognostic test is the observed proportion of the population who … Much as for a diagnostic test, a systematic review of a prognostic test could then assess the accuracy … effect in subgroups defined by the predictve test, along with a statistical test for interaction between … Was the test used and interpreted the same way by all sites/studies including any interdeterminate test … Grouped Mortality Probabilities Estimated by the First Prognostic Test + a New Prognostic Test

18. Chapter 2. Developing the Topic and Structuring Systematic Reviews of Medical Tests: Utility of PICOTS, Analytic Frameworks, Decision Trees, and Other Frameworks | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-topics/methods
    December 01, 2019 - pathways, technical details of the test, characteristics of clinicians or operators using the test, management … to improved clinical outcomes, compared to an existing test. … as the old test and the new test has advantages over the old test, such as causing fewer adverse effects … under evaluation and the comparator test. … the old test and the new test has advantages over the old test, such as having fewer adverse effects,

19. Chapter 10: Deciding Whether To Complement a Systematic Review of Medical Tests With Decision Modeling | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-decision-models/methods
    December 01, 2019 - Define how the test will be used. … (test-and-treat strategy) based on considerations of test characteristics alone. … no PET as an add-on test). … However, in other cases, harms can be induced both by the treatment and the test (e.g., if the test is … the clinical utility of a test.

20. Methods Guide for Medical Test Reviews - Editorial (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews - Editorial E-1 Editorial Methods Guide for Authors of … The most common outcome in an evaluation of this test is the accuracy of the test in identifying clinically … Clinicians, while interested in this proxy outcome, would find more value in the ability of the test … Cochrane Diagnostic Test Accuracy Working Group. Handbook for DTA reviews. … Editorial printed in Methods Guide for Medical Test Reviews (AHRQ Publication No. 12-EHC017).