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1. Using Pragmatic Clinical Trials to Test the Effectiveness of Patient-Centered Medical Home Models in Real-World Settings (pdf file)
   pcmh.ahrq.gov/sites/default/files/attachments/UsingPragmatic_032513comp.pdf
   March 01, 2013 - Pragmatic Clinical Trials Traditional randomized, controlled trials (RCTs) are considered the “gold … Pragmatic trials. … Pragmatic trials. … Pragmatic clinical trials. … Pragmatic Clinical Trials Introduction to Pragmatic Clinical Trials II.

2. Using Pragmatic Clinical Trials to Test the Effectiveness of Patient-Centered Medical Home Models in Real-World Settings | PCMH Resource Center
   pcmh.ahrq.gov/page/using-pragmatic-clinical-trials-test-effectiveness-patient-centered-medical-home-models-real
   March 01, 2013 - Pragmatic Clinical Trials Traditional randomized, controlled trials (RCTs) are considered the “gold … Pragmatic trials. … What are pragmatic trials? BMJ 1998;316(7127):285. … Pragmatic trials. … Pragmatic clinical trials. Comp Ther Med 2004; 12:136-40.

3. Library of PCOR Resources | Agency for Healthcare Research and Quality
   pcmh.ahrq.gov/pcor/library-of-resources/index.html
   April 01, 2021 - Most of the records describe clinical trials (also called interventional studies). … observational studies and programs providing access to investigational drugs outside of clinical trials … FDAAA requires the submission of results for certain trials. … FDAAA also established penalties for failing to register or submit the results of trials. … The reviews in PubMed Health are derived from systematic reviews of clinical trials.

4. Overview: Getting Patients Off the Ventilator Faster: Facilitator Guide | Agency for Healthcare Research and Quality
   pcmh.ahrq.gov/hai/tools/mvp/modules/vae/overview-off-ventilator-fac-guide.html
   February 01, 2017 - breathing trials (SBTs). … They were able to increase spontaneous breathing trials by 16 percent. … And, they were able to substantially improve the rate of spontaneous breathing trials being done with … and spontaneous awakening trials. … with spontaneous awakening trials.

5. Expanding the Toolbox: Methods to Study and Refine Patient- Centered Medical Home Models | PCMH Resource Center
   pcmh.ahrq.gov/page/expanding-toolbox-methods-study-and-refine-patient-centered-medical-home-models-0
   March 01, 2013 - X X   Pragmatic Clinical Trials Deborah Peikes, Kristin Geonnotti, and Winnie Wang Pragmatic clinical … trials (PCTs) are randomized, controlled trials that better meet the needs of decisionmakers regarding

6. Community Physician's Network | Agency for Healthcare Research and Quality
   pcmh.ahrq.gov/ncepcr/communities/pbrn/registry/community-physicians-network.html
   January 01, 2012 - pipemu@msm.edu Network Member Role: Associate Professor of Medicine and Director, Clinical Trials … Clinical Trials Training and Certification of physicians; and g.

7. Pain Management Injection Therapies for Low-back Pain: Topic Refinement (pdf file)
   pcmh.ahrq.gov/sites/default/files/wysiwyg/research/findings/ta/topicrefinement/lbpinject-topicref.pdf
   March 03, 2014 - In randomized trials of low back pain injection therapies, what is the response rate to different types … most injection therapies (with the exception of epidural steroids), inconsistency of results across trials … For example, trials of facet joint radiofrequency denervation vary in the duration and intensity of … the ablative therapy, as well as in the specific anatomic site where it is applied.17 Among trials of … • For Key Question 4: Randomized controlled trials or controlled cohort studies 5

8. Appendix 3: Data Abstraction (xls file)
   pcmh.ahrq.gov/sites/default/files/wysiwyg/research/findings/ta/topicrefinement/ced-appendix3-data-abstraction.xlsx
   June 24, 2022 - NAM2017 Preapproval pragmatic trials have been carried out in the United Kingdom, where the National … NAM 2018 Safety monitoring in real-world trials NAM 2018 Results more generalizable and relevant NAM … NAM2019 Design Hybrid approaches such as pragmatic trials and cluster randomized designs require some … These patients may require additional monitoring, and the trials will likely yield more generalizable … CMS Design_bias For observational, and in some cases randomized controlled trials, the method in that

9. Aspirin Use in Primary Care (pdf file)
   pcmh.ahrq.gov/sites/default/files/wysiwyg/evidencenow/heart-health/aspirin-detail-aid.pdf
   April 01, 2016 - calculator incorporates race into the risk assessment and focuses on evidence from randomized control trials … Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial … Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin. … Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials

10. Appendix B. Detailed Research Domain Framework Definitions and Classification Rules | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/healthsystemsresearch/hspc-research-study/appendix-b.html
    June 01, 2020 - Non-HSR/PCR clinical trials—While clinical trials that focus on primary care are considered to be PCR … , many clinical trials are not. … , cost, or other HSR domains, many clinical trials have no HSR components. … These non-HSR/PCR clinical trials are most commonly conducted in a nonprimary care, controlled setting … Non-HSR clinical trials that examine patient health outcomes (which would otherwise fall under Quality

11. Fall Prevention Toolkit (doc file)
    pcmh.ahrq.gov/sites/default/files/wysiwyg/professionals/systems/hospital/fallprevention-training/module1/module1_tools.docx
    March 01, 2013 - Table 1, Chapter 19 Components of multi-factorial falls prevention trials in hospitals, 1999 to 2009. … None of the controlled trials of fall prevention programs explicitly articulate the conceptual framework … Broader inclusion standards than the Cochrane review led to the inclusion of 43 trials, case-control … Most trials of fall prevention programs have not reported any harms. … Fourteen of 17 trials were considered “low” cost in terms of equipment and environment (meaning some

12. HHS Awards $45 Million in Grants to Expand Access to Care for People with Long COVID | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/news/newsroom/press-releases/long-covid-grant-awards.html
    September 01, 2023 - advance the effort, NIH RECOVER launched the opening of enrollment for phase 2 Long COVID clinical trials … in July that will evaluate at least four potential treatments, with additional trials beginning by the

13. Protection of Human Subjects | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/funding/policies/human-subjects/index.html
    June 01, 2022 - AHRQ Guidance on Posting Informed Consent Forms for AHRQ-Funded Clinical Trials . … AHRQ Guidance on Posting Informed Consent Forms for AHRQ-Funded Clinical Trials .

14. Effectiveness of Pre-Exposure Prophylaxis To Prevent HIV Infection: Findings of a Systematic Review | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/data/visualizations/hiv-prep.html
    October 01, 2023 - visualization displays pooled estimates of meta-analysis results and individual study estimates of trials

15. Expanding the Toolbox: Methods to Study and Refine Patient-Centered Medical Home Models (pdf file)
    pcmh.ahrq.gov/sites/default/files/attachments/ExpandingtheToolkit_031513comp.pdf
    March 01, 2013 - X X Pragmatic Clinical Trials Deborah Peikes, Kristin Geonnotti, and Winnie Wang Pragmatic clinical … trials (PCTs) are randomized, controlled trials that better meet the needs of deci- sionmakers regarding

16. How Learning Health Systems Learn: Lessons from the Field | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/learning-health-systems/how-lhs-learn.html
    May 01, 2019 - developing capacity to not only analyze the observational data but also to conduct experiments (pragmatic trials … specialist at KPSC who actively scans the literature to identify high-quality randomized controlled trials … and systematic reviews of randomized controlled trials. … Quarterly, the senior evidence specialist screens approximately 1,000 newly published trials and typically … Contemporary Clinical Trials . October 24, 2015.

17. Peer Review at AHRQ - Study Sections | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/funding/process/study-section/peerrev.html
    March 01, 2024 - and administrators, policymakers and consumers; and randomized controlled health IT related clinical trials … and effectiveness research; systematic evaluation of clinical interventions; randomized controlled trials

18. Peer Review: Study Section Descriptions | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/funding/process/study-section/peerdesc.html
    July 01, 2017 - and administrators, policymakers and consumers; and randomized controlled health IT related clinical trials … and effectiveness research; systematic evaluation of clinical interventions; randomized controlled trials

19. Resident Physicians as Champions in Preventing Device-Associated Infections Pocket Guide | Agency for Healthcare Research and Quality
    pcmh.ahrq.gov/hai/cauti-tools/phys-championsgd/pocketguide.html
    December 01, 2017 - placed lines within 24 hours Mechanical Ventilation Evaluate for sedation vacation and weaning trials

20. Final Topic Refinement Document - Therapeutic Options for Obesity in the Medicare Population (pdf file)
    pcmh.ahrq.gov/sites/default/files/wysiwyg/research/findings/ta/topicrefinement/obesity_topic-refinement.pdf
    May 22, 2014 - applications in the elderly is unknown, because the elderly have largely been excluded from clinical trials … significant weight loss without significant risk to obese older adults.6 The review identified 10 trials … It did not identify any studies of pharmacologic options among the elderly or any trials of bariatric … or under 65 years old and disabled), but we found approximately 640 potentially relevant randomized trials … We reviewed 100 of these potentially relevant randomized trials and found eight that were applicable