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effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
March 10, 2010 - permutations of dosing which may be of interest and can be
explored in other reviews specifically targeted
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
October 07, 2011 - Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx
Source: www.effectivehealthcare.ahrq.gov
Published Online: October 7, 2011
Comparative Effectiveness Research Review Disposition of Comments Report
Research Review Title: Comparative Effectiveness of Angiote…
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effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
January 01, 2014 - High Impact: Moderately high impact
Rilonacept (Arcalyst) for Treatment of Gout
Key Facts: The targeted … York, NY) is selective and potent oral tyrosine kinase
inhibitor that is being investigated as a targeted … York, NY) is a selective and potent oral tyrosine kinase inhibitor that is being
investigated as a targeted … The experts agreed
that the underlying theory behind tofacitinib action is sound, providing a new targeted … Trial watch: BLYS-targeted
antibody shows promise in Phase III SLE trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
November 01, 2009 - faster than malignant ones, with each radiotherapy session the
accumulated cellular damage in the targeted … Contrary to particle beam therapy, the targeted tumor volume cannot be covered by a single
radiation
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-cough_disposition-comments.pdf
January 07, 2013 - Comment Response
TEP #1 General There is an additional concern about the findings in light of the
targeted … While "non-specific" treatments for chronic cough
are important, I would value more of a targeted approach … actually specifically targeted the population of
interest. … TEP #1 Clarity/Usability Further study on the role of heightened sensory receptors, and
more targeted … The scope of this report was not to
address targeted pharmacotherapy,
but we agree that any additional
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
June 09, 2021 - Peer
Reviewer #2
Evidence
Summary
There is no mention of targeted therapy in the
summary section … Later on it becomes clear that
targeted therapy is combined with cytotoxic
chemotherapy. … We clarified that
systemic therapy refers to
chemotherapy, targeted therapy
or immunotherapy. … use of the term
'chemotherapy' when referring to
analyses that include cytotoxic
chemotherapy and targeted … Affiliation
Section Comment Response
Peer
Reviewer #2
Methods It appears chemotherapy combines targeted
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
March 22, 2023 - However, if a study enrolls children with conduct disorder and DMDD and the intervention targeted
disruptive … Exclude school wide or system wide
settings (e.g., juvenile justice system)
wherein interventions are targeted
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
January 01, 2009 - Hi Les,
Medical Tests—White Paper Series
Using the Principles of
Randomized Controlled Trial Design
To Guide Test Evaluation
The findings and conclusions in this document are those of the authors, who are responsible
for its contents; the findings and conclusions do not necessarily represent t…
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effectivehealthcare.ahrq.gov/sites/default/files/ch_5-user-guide-to-ocer_130129.pdf
January 01, 2012 - 59
Abstract
This chapter discusses considerations for comparator selection in observational comparative effectiveness
research (CER). Comparison groups should reflect clinically meaningful choices in real world practice
and be chosen based on the study question being addressed. Recognizing the implications and pote…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer
Comparative Effectiveness Review
Number 259
Partial Breast Irradiation for
Breast Cancer
Executive Summary
Main Points
• There was no significant difference between partial breast irrad…
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effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Having an
effective medication targeted at the core social deficits of ASD in early childhood could … Having an effective medication targeted at the core social deficits
of ASD in early childhood could
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
April 01, 2017 - AT is a site principal investigator for the Targeted Intraoperative Radiotherapy (TARGIT-A) trial and … Risk-adapted targeted
intraoperative radiotherapy versus whole-breast radiotherapy for
breast cancer: … Pride, Prejudice, or Science:
Attitudes Towards the Results of the TARGIT-A Trial of Targeted
Intraoperative … Radiation-related quality of life
parameters after targeted intraoperative radiotherapy versus whole
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-de-novo-processes_methods.pdf
September 01, 2009 - One strategy is to use a targeted search of higher yield
databases.2 Because SRs are a secondary literature … By
specifying the targeted search databases and terms used to locate existing SRs and
employing a flow … These include:
• Determining whether the targeted SR search strategy that has been proposed
in this … Conducting targeted SR search using
a priori defined PICOTS-SD
Use de novo
methods
STEP 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/systematicreviewsreplacedenovo.pdf
September 01, 2009 - One strategy is to use a targeted search of higher yield
databases.2 Because SRs are a secondary literature … By
specifying the targeted search databases and terms used to locate existing SRs and
employing a flow … These include:
• Determining whether the targeted SR search strategy that has been proposed
in this … Conducting targeted SR search using
a priori defined PICOTS-SD
Use de novo
methods
STEP 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/community-health-worker-protocol.pdf
March 26, 2019 - Grey Literature search
Targeted gray literature searching will include reports and presentations published … community health worker; CVD = cardiovascular disease
We will focus on PubMed and CINAHL, with targeted
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nursing-home-safety_research-protocol.pdf
July 22, 2015 - Thus, the outcomes targeted for prevention are often the same: falls, pressure ulcers,
delirium and … Grey Literature search
Technical briefs combine contextual information from Key Informants with targeted … Inclusion and Exclusion
For GQ 1, 2, and 4 we will conduct targeted literature searches to address the
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
February 01, 2014 - Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention
Methods Research Report
Evaluation of the Benefits and Harms of Aspirin for
Primary Prevention of Cardiovascular Events: A
Comparison of Quantitative Approaches
…
-
effectivehealthcare.ahrq.gov/sites/default/files/study-objectives-and-questions-chapter-1.pptx
January 01, 2013 - expected effects of the interventions based on current understanding of the pathophysiology of the targeted … expected effects of the interventions based on current understanding of the pathophysiology of the targeted
-
effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
January 01, 2011 - statistically like confounders,
but pathways that include colliders are considered
closed and do not bias the targeted
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
June 01, 2011 - Layout 1
Background
Almost 75 million American adults—
approximately one-third—have
hypertension. The prevalence of
hypertension increases with advancing age
such that more than half of people 55 to 74
years old and approximately three-fourths
of those age 75 years and older are
affected. In addition to being the pr…