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21. Effectiveness of Indoor Allergen Reduction in Management of Asthma - Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-reduction-asthma-evidence-summary.pdf
    February 01, 2018 - No single allergen interventions were determined to be necessary or sufficient for effectiveness. … research is needed examining indoor allergen reduction interventions in comparative studies with sufficient … Throughout this review, we found that the evidence base lacks sufficient high-quality studies to inform

22. Evidence-based Practice Center Systematic Review Protocol: Prehospital Airway Management (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prehospital-airway-management-protocol.pdf
    December 20, 2019 - Study Design • RCTs If RCTs do not provide sufficient evidence, the following designs will be included … Then we will evaluate whether the RCTs are sufficient to address a Key Question or sub-question based … If we believe the RCTs are sufficient, and with the concurrence of our clinical experts, we will then … If the RCTs are not sufficient, we will assess the observational studies for risk of bias and then include … High risk of bias studies may be excluded if sufficient low and moderate studies are available.

23. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
    July 13, 2011 - Sometimes it is sufficient for the manufacturer to demonstrate bioequivalence. … Eligible study designs include original research studies that provide sufficient detail regarding methods … Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses When sufficient … A “fair” study is susceptible to some bias but probably not sufficient to invalidate its results. … If we cannot find sufficient evidence for these outcomes we will include proxies to health outcomes

24. Topic 0494 Tacrolimus Monitoring and Treatment Renal Transplantation NSD FINAL (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
    March 13, 2013 - comparative effectiveness question; should probably be a subquestion of KQ1]: Are analytical capabilities sufficient … Sensitivity of monitoring for low dose CNIs: Are analytical capabilities sufficient to measure CNIs

25. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
    December 20, 2011 - Was the outcome defined clearly (i.e., was the measure described in sufficient detail to be replicated … Was the exposure defined clearly (i.e., was the test method described in sufficient detail to permit … Was the exposure defined clearly (i.e., was the test method described in sufficient detail to permit … Was the exposure defined clearly (i.e., was the test method described in sufficient detail to permit … Was the exposure defined clearly (i.e., was the test method described in sufficient detail to permit

26. Preterm-Birth-Terbutaline-Pump Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_surveillance.pdf
    January 30, 2013 - experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … d evidence sufficient to invalidate the findings. … (Yes/No/Don’t know) Are you aware of any new evidence that is sufficient to invalidate the finding

27. Preterm-Birth-Terbutaline-Pump Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_surveillance.pdf
    January 30, 2013 - experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … experts stated that the conclusion was still valid, and they were not aware of any evidence sufficient … d evidence sufficient to invalidate the findings. … (Yes/No/Don’t know) Are you aware of any new evidence that is sufficient to invalidate the finding

28. Evidence-based Practice Center Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ongoing-studies-evidence_research.pdf
    December 01, 2010 - • Does the database provide sufficient information about the study? … Ideally, available information regarding ongoing studies should be efficiently identifiable and sufficient … • The data provided about the ongoing studies are sufficient to gain a basic understanding of the … The data provided about the ongoing studies are sufficient to gain a basic understanding of the research … The data provided about the ongoing studies are sufficient to gain a basic understanding of the research

29. Treatments for Adults with Schizophrenia: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
    September 23, 2016 - evidence for intervention categories in Key Question 2, we will determine bodies of evidence that are sufficient … high quality systematic reviews of the interventions in Key Question 1 that have found the evidence sufficient … For interventions with sufficient evidence based on quality of included studies, we will then assess … For other bodies which have sufficient quality and precision, the rest of the strength of evidence … , including reasons for being deemed insufficient Those Key Question 2 intervention areas deemed sufficient

30. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
    January 28, 2016 - There should be sufficient data to support a statement that serologic tests are highly accurate in … We do not feel this evidence is sufficient. … We also include your recent study which found that 3 grams is sufficient (Leffler, 2012). … We have added results on accuracy of IgG DGP tests in IgA sufficient patients to Key Question 1. … We also include in the results Leffler’s study finding that 3 grams is a sufficient dosage (Leffler

31. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
    May 02, 2025 - biomarker-targeted interventions can be small and lack comparative studies, and that single- arm studies have been sufficient … Abstracts and meeting presentations do not contain sufficient details about experimental methods to … and demographic subgroups for KQs 2 and 3, we will prioritize analyzing within-study comparisons if sufficient … If the evidence is sufficient to permit a conclusion, the rating is deemed high, moderate, or low.

32. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
    December 09, 2009 - The specific treatments that have sufficient research to merit a comparative review would be limited … Admissible evidence (study design and other criteria) Original research studies that provide sufficient … A “fair” study is susceptible to some bias but probably not sufficient to invalidate its results. … However, if we find a sufficient number (three or more) of similar studies of factors influencing the

33. Ch-7-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch-7-user-guide-to-ocer_130129.pdf
    March 29, 2012 - Sufficient knowledge, however, is likely rare when conducting studies across a wide geography and many … The goal is to use the graph to identify a sufficient set of variables to achieve unconfoundedness, … If the graph is correct, it can be used to identify a sufficient set of covariates (C) for estimating … A sufficient set C is observed when no variable in C is a descendant of A 0 and C blocks every open … It can be shown that when any subset of observed variables is sufficient to control confounding, the

34. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_executive.pdf
    February 01, 2006 - Layout 1 Background Breast cancer is the second most common malignancy in women. The American Cancer Society estimated that in the United States in 2005, 212,930 women would be newly diagnosed as having breast cancer and there would be 40,870 deaths due to this disease. Because early breast cancer is asymptomatic, th…

35. Slide 1
    effectivehealthcare.ahrq.gov/sites/default/files/selection-of-data-sources-chapter-8.pptx
    January 01, 2013 - The data source must be chosen carefully to ensure it: Can address the study question Has a sufficient … number of observations Contains key variables including potential confounders Allows for sufficient … data source must be chosen carefully to ensure that it can address the study question, that is has a sufficient … observations, that key variables are available, that there is adequate confounder control, and that there is a sufficient … the research question of interest, particular attention must be paid to ensure that data quality is sufficient

36. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
    October 05, 2012 - Similarly we also anticipated that the decision to pool studies would be based if there were sufficient … studies selected a similar population and reported an outcome that was measured similarly and with sufficient … Sufficient detail for an outcome measured as a mean, such as length of stay, requires reporting of standard … For critically ill/VAP, we had sufficient information to perform meta-analysis using 3 of 5 studies … For RTI, 4 of 7 studies reporting on this outcome provided sufficient information to be included in

37. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
    January 01, 2009 - strategy, more elaborate and therefore more expensive forms of evaluation should only be performed if sufficient … evaluation strategy, more elaborate and therefore more expensive types of studies are performed only if sufficient … management and policy decisions, given the current rapid advances in technology.38 Accuracy may be sufficient … Accuracy studies are neither sufficient nor always necessary for showing improvement in patient outcomes … When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do

38. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
    January 01, 2009 - strategy, more elaborate and therefore more expensive forms of evaluation should only be performed if sufficient … evaluation strategy, more elaborate and therefore more expensive types of studies are performed only if sufficient … management and policy decisions, given the current rapid advances in technology.38 Accuracy may be sufficient … Accuracy studies are neither sufficient nor always necessary for showing improvement in patient outcomes … When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do

39. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
    January 01, 2012 - internal validity of SRs: comprehensiveness of literature search, criteria used to select articles, sufficient … If the SR lacks sufficient internal validity, then it may not be possible to trust its findings and … Included studies of sufficient validity and quality 4. … Similarity, or degree of homogeneity, of included studies 11 If there is sufficient uncertainty … Implication: 72 hours was sufficient as most participants completely improved by then, no need for longer

40. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
    May 01, 2006 - The evidence is not sufficient for conclusions on effects of either epoetin or darbepoetin on quality … following pairs of dosing strategies,d one large trial 4 c To test survival, a trial should enroll sufficient … The largest of these studies do not report sufficient predictive ability for any algorithm to establish