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Showing results for "substantial".

41. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
    June 01, 2010 - many public programs target these populations the costs of preterm birth in the public arena are substantial … by the Institute of Medicine titled Preterm Birth: Causes, Consequences, and Prevention, reflects substantial … all at-risk pregnant women were treated with 17-OHP, the aggregate medical cost savings could be substantial

42. Disposition of Comments Report for Comparative Effectiveness Review No. 137 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-update_disposition-comments.pdf
    August 06, 2014 - the safety, health, and overall functioning in people with ASD who are over the age of 7 or have substantial … There are substantial differences between thorough going behavior analytic interventions and interventions … Definition and categorization of interventions represents a substantial challenge in this field. … do not disagree with the reviewer’s apt critiques that the categorization utilized is not without substantial … do not disagree with the reviewer’s apt critiques that the categorization utilized is not without substantial

43. Test-Performance-Metrics Appendixes (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
    January 01, 2005 - A-1 Appendix: Test Performance Metrics The basic definitions of test performance are based upon a 2×2 cross tabulation of the “true disease status” and the test results (Appendix Table). Ostensibly simple, the information in a 2×2 table can be summarized in several ways—some of which are mathematically equivale…

44. Guidelines-Peer-Public-Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/Guidelines-Peer-Public-Review.pdf
    November 08, 2013 - Guidelines-Peer-Public-Review …

45. Comparative Effectiveness Review No. 258_Diagnostic Errors in the Emergency Department: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
    August 01, 2023 - Nevertheless, substantial variability in diagnostic error rates by disease, presenting symptoms, demographic … Resources applied should be commensurate with the measured public health burden, which is likely substantial

46. Depression-Postpartum-Screening Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
    May 01, 2013 - Condition and Preventive Strategies Depression is a potentially life-threatening condition with a substantial … between screening instruments, and the studies that directly compared instruments did not identify substantial … sensitive test (such as the “two-question screen”) followed by the use of a more specific test results in substantial … standardized screening instrument in women who answer yes to one of the questions would appear to have substantial

47. Gastric-Cancers-Supplementary-App-D (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
    January 01, 2023 - Some concerns Low Low Low Some concerns Analysis does not follow intention-to-treat principles, but substantial

48. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
    September 01, 2011 - It was difficult to determine whether the division of studies into Tiers 1, 2 and 3 resulted in a substantial … Our analyses, though limited to a small number of studies, did not suggest a substantial difference … BA 25) has substantial efficacy in experimental studies, yet this is not described. … Also, reference to the substantial, contemporary body of work from the investigative group at Columbia … For example, many of the major ECT efficacy studies were conducted decades ago and despite substantial

49. Breast Abnormalities Update Surveillance Assessment_CER 47_Low (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
    September 01, 2012 - A2 Substantial harm: A pivotal trial or systematic review (or guidelines) whose results called into … • If we found substantial new evidence that might change the CER conclusion, and/or a majority of … However, the data were found to contain significant heterogeneity (I 2 = 64.0%), indicating substantial … heterogeneous (I 2 = 68.0% and I 2 = 54.6% for sensitivity and specificity, respectively), indicating substantial … However, the data were found to contain significant heterogeneity (I 2 = 64.0%), indicating substantial

50. Executive Summary_Systematic Review: Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-research-executive-summ.pdf
    April 01, 2025 - There was substantial heterogeneity across age groups regarding criteria and methods of population … enrollment (e.g., primary diagnosis, concomitant diagnoses), as well as substantial heterogeneity in

51. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
    September 01, 2009 - Data were synthesized qualitatively when heterogeneity was substantial (I2 greater than 50 percent). … Substantial heterogeneity precluded statistical analysis of 18 statin-ezetimibe and 4 statin-BAS trials … of 3 to 20 percent favoring statin-ezetimibe combination therapy were noted in all 10 trials, with substantial … statins and doses in all trial populations, 20 statin-ezetimibe trials were not meta-analyzed because of substantial

52. Methods Guide for Medical Test Reviews Chapter 3 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
    July 01, 2012 - Mammography is a useful example, since the emotional reaction to a false positive test may be substantial … Correspondingly, the potential legal consequences of a false negative test are substantial, as a false … effects of testing may reach beyond the tested individual and affect society if many individuals have substantial

53. Research Protocol: Disparities Within Serious Mental Illness (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-disparities_research-protocol.pdf
    July 01, 2015 - disorders, if the degree of functional impairment is severe).3,4 SMIs are long-term illnesses involving substantial … To facilitate broad participation, we will use staff with substantial experience in moderating calls

54. Health Information Exchange (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-information-exchange_executive.pdf
    December 01, 2015 - A substantial investment of resources is needed to develop an environment that allows health care information … These efforts have resulted in substantial growth of HIE across the United States.2 The purpose of … Despite substantial progress in EHR adoption, health information exchange and patient engagement remain … Operational health information exchanges show substantial growth, but long- term funding remains a concern

55. Disposition of Comments Report for Medication Adherence Interventions: Comparative Effectiveness (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-adherence-interventions_disposition-comments.pdf
    September 11, 2012 - extensive and covered many key points; however, its usability is limited because the few RCTs had substantial … Potential users can glean this information from the tables that summarize the studies, but it requires substantial … This results in substantial repetition in the body of the report.

56. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
    July 01, 2011 - Question; NIDDM, non-insulin-dependent diabetes mellitus; QoL, quality of life. 5 When there were substantial … Analysis of difference versus average analyses plots suggest that substantial differences in the measured … suggestive of OSA with high positive likelihood ratios and low negative likelihood ratios,” though “substantial … • Conclusion: The strength of evidence is low of no substantial difference in compliance or other … Substantial jaw pain was reported in about 2–4% of patients, but no study reported on the long-term

57. S131 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
    October 01, 2007 - that very few patients were excluded; exclusions based on contraindications can be expected to be more substantial … We found that this change resulted in an observable but not substantial change in RR estimates in our … The large size of health care utilization databases can allow performing such subgroup analyses with substantial

58. Hip-Fracture-Pain Clinician (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_clinician.pdf
    May 01, 2011 - Morbidity and poor functional recovery is substantial, with 25 percent of women and 50 percent of

59. Template for Reports Developed (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
    October 26, 2012 - Substantial differences in false positives, that is, specificity, were not found among the tests that … Substantial differences in false positives, that is, specificity, were not found among the tests that … May require substantial personnel time but is generally less resource intensive than primary studies … Likely to require substantial resources to recruit adequate sample sizes, as multiple sites may be … Likely to require substantial resources to recruit adequate sample sizes.

60. Research White Paper - Assessing the Predictive Validity of Strength of Evidence Grades: A Meta-Epidemiological Study (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
    September 01, 2015 - Likewise, a rating of “low SOE” would reliably predict a high likelihood that future studies will have a substantial