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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
    January 01, 2013 - All but one study were RCTs. … This study had low risk of bias and showed no differences between the medication groups. … The SOE was rated as low due to the potential imprecision of this study. Key Question 2. … All but one study were RCTs. … This study had low risk of bias and showed no differences between the medication groups.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_disposition-comments.pdf
    May 24, 2013 - We had included the article in our screening and found that the study includes patients treated from … Peer Reviewer #4 Conclusions As for the QOL, the study referenced above may need to be factored … One study did present data on RFA compared to TACE for patients with lesions that were all amenable … These are areas of intense clinical importance that require further study. … The RFA compared with TACE has been removed from this report with the exception of one study.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
    December 16, 2011 - A cross-sectional study by Gabbe et al. found that 96 percent of obstetricians routinely screen for … A recent study found that the IADPSG criteria increased GDM prevalence nearly threefold compared with … There will be no restriction on study sample size. … We will report adverse events as they are reported by the authors of the study. … Hyperglycemia and adverse pregnancy outcome (HAPO) study Cooperative Research Group.
  4. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
    February 01, 2012 - In addition, we contacted drug manufacturers to request published and unpublished study data. … The mean age of study participants ranged from 4.0 to 21.5 years (median = 13.6). … One study provided separate data for both bipolar disorder and schizophrenia. … One study found greater improvement in autistic symptoms with risperidone than placebo (low strength … (MD = -27, 95% CI: NR); significance in second study NR.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/bundled-payments-quality-effects_research-protocol.pdf
    June 23, 2011 - We will not limit our study to any specific comparators. …  Study Outcomes. …  Study Outcomes. Same as for KQ 1.  Timing. Same as for KQ 1.  Settings. …  Study Outcomes. Same as for KQ 1.  Timing. Same as for KQ 1.  Settings. … The bundled payment intervention meets other inclusion criteria and the study addresses the key study
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
    December 09, 2009 - Exclusion criteria Study design Observational study designs with no comparison group (case reports, … A two-step process will be used for study selection. … No language or study design restrictions will be applied. … We will also report on sources of funding for each included study. … A one-year, prospective, observational cohort study with matched-pair analysis.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
    December 09, 2009 - or adolescents Studies which include patients with treatable depression or healthy volunteers Study … If both reviewers agree that a study does not meet the eligibility criteria, the study will be excluded … In general terms, a “good” study has the least bias and results are considered to be valid. … A “fair” study is susceptible to some bias but probably not sufficient to invalidate its results. … Therefore study questions, design and/or methodological approaches do not necessarily represent the
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
    May 19, 2011 - Criteria for Inclusion/Exclusion of Studies in the Review The study eligibility criteria are: … Study design. … We will seek the TEP’s help to establish study eligibility criteria. … The elements will include study identifiers, study design characteristics, patient characteristics, … Therefore study questions, design and/or methodological approaches do not necessarily represent the
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
    September 07, 2012 - The Meis study has been changed to good. … The O'Brien study is considered to have a low dropout rate. … the study. … However, it appears that the Northen study of participants from the Mies MFMU network study (reference … Infant outcomes are the only reasons to study these interventions.
  10. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
    December 01, 2011 - Overall, study quality is low. … As found with the other KQs, overall, study quality was low. … Further study of the differences in false positives, if any, is needed, too. … Available evidence is generally from before–after study designs or limited time series. … Handwashing/alcohol gel Low • No study examined whether handwashing reduced CDI incidence.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating-disposition-160504.pdf
    December 09, 2015 - The diagnostic criteria of each included study is clearly identified. … study groups were too small to be evidence for course of illness. … (and below, in the methods, in terms of study selection/inclusion). … , not a bariatric surgery study. … The design of each study is included in the results.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
    January 01, 2014 - We are aware that such definitions are difficult because they often vary from study to study, but this … The treatment durations varied by study. … We cite only the main paper for each study. … We cite only the main paper for each study. … We cite only the main paper for each study.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/tonsillectomy_research-protocol.pdf
    February 10, 2016 - In  their  seminal  study,   Wennberg  and  Gittlesohn  found  the  rate  of  tonsillectomy  varied   … Furthermore,  this  study  included  only  randomized  controlled  trials  (RCTs).     …  design.26  Two   investigators  will  assess  each  included  study  independently.   … data;;  that  is,  they  describe  only  between-­study  and  not  between-­patient  variation.   … A  population-­based  study  of  acute  care   revisits  following  tonsillectomy.  
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
    December 01, 2010 - Study inclusion in the CER will not be limited by drug dosage. 4. … Only the full study reports will be included in the CER. … A two-step process will be used for study selection. … of study funding, study design, methodological quality criteria (see below), study population (including … study inclusion and exclusion criteria, run-in period, study withdrawals, length of study, duration
  15. effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
    January 01, 2011 - Improving Characterization of Study Populations: The Identification Problem John M. … population who were exposed to the treatment under study. … population who were not exposed to the treatment under study. … However, at the end of the study it may be unclear as to whether the study identified the comparative … Improving Characterization of Study Populations: The Identification Problem ii.
  16. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - Bivariate random-effects meta-analysis and the estimation of between-study correlation. … Perform a multivariate meta-analysis (when each study reports a single threshold). … Step 3: Explore Between-Study Heterogeneity The third and last step in the algorithm is to explore between-study … Sensitivity and specificity are dependent on the prevalence of the condition under study. … Bivariate random-effects meta-analysis and the estimation of between-study correlation.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
    January 01, 2014 - The reviewers extracted information on general study characteristics (e.g., study design, study period … The study found sclerotherapy produced more rapid wound healing. … Cadexomer Iodine Study Group. Int J Dermatol. 1998;37(5):390-6. PMID: 9620490 25. … Prospective, multicenter study of managing lower extremity venous ulcers. … A randomized prospective study. Acta Derm Venereol. 1994;74(4):307-9. PMID: 7976095 69.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - Bivariate random-effects meta-analysis and the estimation of between-study correlation. … Perform a multivariate meta-analysis (when each study reports a single threshold). … Step 3: Explore Between-Study Heterogeneity The third and last step in the algorithm is to explore between-study … Sensitivity and specificity are dependent on the prevalence of the condition under study. … Bivariate random-effects meta-analysis and the estimation of between-study correlation.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_disposition-comments.pdf
    November 27, 2012 - This study is published only in abstract form. … I would not include anything that does not have a study to support it. … I think the prevalence in this study at 1.5% is misleading. … However, as shown in Table 10 the range of augmentation incidence was quite variable from study to study … to study and appeared to be lower with dopamine agonists than L-dopa.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
    May 26, 2017 - We added the study noted below while the report was undergoing peer review. … We have added the atomoxetine study. … We agree and have removed discussion of this study. … We have revised our discussion of this study. … We note the high percentage of ear pain (which did not lead to study withdrawal) in one study.

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