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effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-applicability.ppt
January 01, 2009 - Applicability issues do not have to be reviewed for each study. … Study Parameters Affect Applicability
Study parameters may affect applicability through these different … In this case, a cohort study might be more applicable for that harm. … First, judge whether or not a study is an effectiveness trial or an efficacy trial. … Study 1
Study 2
Study 3
Study 4
Higher Age
Lower Age
Study 4
Study 1
Study 3
Study 2
Scenario
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
January 01, 2010 - drug’s
effects, to better understand “failings” in a given
study, and to optimize subsequent study … We
calculated the numbers from the raw data available in each study. … , but in particular,
this study, requires a reviewer that has an
understanding of study design methodology … This negative study has not been published. … results into the single allergen study
findings.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
May 01, 2008 - Study Design and Setting: Case-control study of persons age 65 and above nested in the UK
General Practice … Overview and Study Population
We performed an observational case-control study nested within the … Study Base
The person-time eligible for inclusion in this nested case-control study (i.e., the study … This study has limitations. … Overview and Study Population
2.2. Study Base
2.3. Identification of Cases
2.4.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
September 01, 2014 - Study Selection
Our criteria are listed in five categories below: (1)
publication criteria, (2) study … Study Design Criteria
a. … Elements abstracted included
general study characteristics (e.g., country, setting, study
design, number … For CT, the study estimated sensitivity at 81
percent and specificity at 82 percent; for MRI, the study … *Possible reporting bias in the single study involving MDCT angiography because the study was performed
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pelvic-pain_executive.pdf
January 01, 2012 - Studies differed considerably in
terms of study populations, interventions, and outcome
measures. … to the intervention under study,
others may not. … Pelvic Pain Study
Group. Obstet Gynecol. 1999 Jan;93(1):51-8.
11. Gestrinone Italian Study Group. … Postural changes in women with chronic pelvic
pain: a case control study. … The Maine Women's
Health Study: II.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - observational study. … study, it is probably not
practical to design a study whose sole purpose is to assess the prognostic … As the study is cross-sectional in nature, the duration of the study is not an issue. … observational study. … or a cohort study.
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effectivehealthcare-admin.ahrq.gov/products/economic-evidence/research
November 01, 2017 - Reviewers also assessed the quality of each study and graded the strength of the body of evidence using … grading of recommendations assessment development and evaluation (GRADE) recommendations, indicating study … studies that provided the economic evidence was a promoting factor (7 studies) in the case of a good study … and a strong obstacle in the case of a poorly presented study (18 studies); (2) transparency and quality … Community-Engaged Evidence Synthesis To Inform Public Health Policy and Clinical Practice: a Case Study
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - Empirical study. … VIGOR
Study Group [see comment]. … Celecoxib Long-term Arthritis Safety Study
[see comment]. … Performance of
propensity score calibration—a simulation
study. … Did the study specify WHO collected the harms?
8.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - Empirical study. … VIGOR
Study Group [see comment]. … Celecoxib Long-term Arthritis Safety Study
[see comment]. … Performance of
propensity score calibration—a simulation
study. … Did the study specify WHO collected the harms?
8.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
August 01, 2015 - Study design:
Allocation: Randomized
Endpoint Classification:
Safety/Efficacy Study
Intervention … Study design:
Allocation: Randomized
Endpoint Classification: Efficacy
Study
Intervention Model: … Study design:
Allocation: Randomized
Endpoint Classification: Efficacy
Study
Intervention Model: … Study design:
Allocation: Randomized
Endpoint Classification: Efficacy
Study
Intervention Model: … Study design:
Endpoint Classification: Safety
Study
Intervention Model: Single Group
Assignment
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
February 01, 2013 - The overall judgment of risk
of bias was based on the overall study conduct, specifically
relating … the study
was particularly large, robust, and of good quality. … No firm conclusions were drawn from this
single, high-risk-of-bias study. … No firm
conclusions were drawn from this single, high-risk-of-bias
study. … The other
study compared the use of IVUS after PTCA with PTCA without
IVUS.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ankyloglossia_executive.pdf
May 01, 2015 - Two reviewers independently assessed the full text of each
included study. … design, descriptions of the
study populations (for applicability), description of the
intervention … Quality assessment of each study was conducted by
two team members independently. … These included 6 RCTs, 1 cohort study, 25 case series,
8
and 15 case reports. … Developing a frenotomy policy at
one medical center: a case study approach.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
September 02, 2016 - Empirical analyses of
prospective registry data can inform on the time between study completion and … Terminology
We use the term study to refer to the conducted research. … Specifically, we
will capture basic information about the study design, study population, intervention … by detailing study
initiation date and rationale for discontinuation or delay. … Detecting and adjusting for small-study
effects in meta-analysis.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - drugs or combinations of study drugs. … If both reviewers agree that a
study does not meet the eligibility criteria, the study will be excluded … In
general terms, a “good” study has the least bias and results are considered to be valid. … A “fair” study is susceptible to some bias but probably not sufficient to invalidate its
results. … Two independent reviewers will assign quality ratings to each study.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
September 19, 2014 - Data extraction for each study was performed by two
investigators. … Two
investigators independently assessed the quality of each
study. … ), overdose (two studies), fracture (one study),
myocardial infarction (one study), motor vehicle accidents … (one study), and use or testosterone replacement or
medications for erectile dysfunction (one study … International Association for the Study of Pain.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
October 01, 2016 - We discussed
the Key Questions, analytic framework, study eligibility
criteria, literature search, … Included
study designs have also been modified slightly. … Study Selection
The DistillerSR software package was used to manage
the search outputs, screening, … (of study
outcome measures), and precision, as well as the number
of studies by study design. … Study interventions or measured exposures tended to be
highly heterogeneous.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
June 16, 2010 - patients but fails to report the number of patients per study arm
we will assign 50 percent of the study … patients to each of the study arms. … Were study clinicians blinded (masked) to the treatment received by individual
study participants? … The study was double-blind.
3. … Between-study heterogeneity will be evaluated by examining measures
of between-study variability (e.g
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
May 13, 2014 - The study design for the Oslin et al study did not
meet our inclusion criteria. … OPRM1 (needs more study). … Neither study meets that criteria. … The Foa
study did not meet our eligible study design criteria
(Foa EB, Yusko DA, McLean CP, et al. … It is, in fact, an included study.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - In addition, we contacted
drug manufacturers to request published and
unpublished study data. … The mean age of
study participants ranged from 4.0 to 21.5 years
(median = 13.6). … One
study provided separate data for both bipolar disorder
and schizophrenia. … One study found greater improvement in autistic
symptoms with risperidone than placebo (low strength … (MD = -27, 95% CI: NR);
significance in second study NR.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
May 26, 2017 - We added the study noted
below while the report was undergoing peer review. … We have added the atomoxetine study. … We agree and have removed discussion of this
study. … We have revised our discussion of this study. … We note the high percentage of ear pain (which did
not lead to study withdrawal) in one study.