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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/selecting-evidence-quiz.ppt
    September 02, 2013 - Refocus the study question on the gaps in trial evidence. … You should refocus the study questions on gaps in trial evidence and search for observational studies … This type of bias can often be minimized through study design and appropriate implementation. … bias refers to systematic differences among comparison groups in the loss of participants from the study … Confounding by indication is a type of selection bias that occurs when study groups differ because they
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_disposition-comments.pdf
    April 25, 2013 - A single study of 1000 patients per arm (2000 total) with a control group on-study mortality rate of … However, when the BEST study was excluded, the point estimate for on-study mortality decreased from … The BEST study was the largest randomized ESA study included in the meta-analysis, and also included … the longest on-study period (12-months) while most other studies included a 3- to 6-month on-study … and Untch et al were excluded from the analysis since no on-study deaths occurred in either study.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ongoing-studies-evidence_research.pdf
    December 01, 2010 - We assessed relevance of each ongoing study according to EPC report criteria for study inclusion. … Additionally, information about the study that helps predict the eventual study quality would also be … results than is described in registered study protocols.13,18 One recent study found that selective … Distribution of publication status by study topic and sponsor Study Topic and Sponsorship Not Published … or completed study results posted to a trials registry.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
    August 10, 2010 - Sample size There are no restrictions for study sample size. … Key study elements will be reviewed by a second person (study investigator) with respect to study outcomes … study design, sample size, clinical indications; and study duration or length of follow-up). … with regards to comparability of study populations, treatments, and outcome measures. … Correlates of methylphenidate use in Canadian children: a cross-sectional study.
  5. S116 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/s116.pdf
    October 01, 2007 - ORIGINAL ARTICLE Evaluating the Validity of an Instrumental Variable Study of Neuroleptics Can Between-Physician … We sought to explore the validity of physician-level IV in a comparative study of short-term mortality … If there are unmeasured variables that are indepen- dent risk factors for the study outcome and also … METHODS Study Population and Data Sources Our study was conducted in a population of Medicare beneficiaries … One important limitation of our study concerns the generalizability of the results.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_executive.pdf
    April 01, 2012 - publications are counted as a single study (with multiple publications). … This study was at low risk of bias. … The SOE was rated as low due to the potential imprecision of this study. Key Question 2. … Phenytoin as an augmentation for SSRI failures: A small controlled study. … Lithium augmentation in sertraline-resistant depression: A preliminary dose-response study.
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - One study reported harms. … No study reported harms associated with imaging for HCC staging. … No study on US with contrast reported harms. … No study evaluated specificity. … MRI Low One study reported similar accuracy.
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
    December 01, 2012 - See the full report for references to each study. 5 KQ1a. … One study was of good quality, 4 of fair quality, and 13 of poor quality. … The one good-quality study of US had an accuracy rate of 73 percent. … LHRH was compared with hCG and placebo in one study of fair quality. … Only one study assessing testicular descent was rated as good quality.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cerebral-palsy-feeding_disposition-comments.pdf
    March 20, 2013 - We reviwed this citation and another related study (PMID 22699104). … The study used very strict inclusion criteria so that a homogenous study population of the most severely … As a result the study took 4 years rather than 2 to complete. … We re-examined the study and have added dat a on our outcomes of interest as reported in this study. … designs for all questions that are important in this field of study.
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
    October 08, 2014 - Elements to be abstracted include general study characteristics (e.g., country, setting, study design … '/exp OR 'controlled study' OR 'clinical trial'/exp OR 'clinical trial' OR 'comparative study'/exp OR … '/exp OR 'prospective study' OR 'retrospective study'/exp OR 'retrospective study' OR 'case control … study'/exp OR 'case control study' OR 'major clinical study'/exp OR 'major clinical study' OR 'evaluation … study'/exp OR 'evaluation study' OR random*:de OR random*:ti OR placebo* OR (singl* OR doubl* OR tripl
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_executive.pdf
    September 22, 2011 - We included a study if it met all of the following criteria: • The study was a randomized controlled … trial (RCT), a cohort study, or a case-control study published in the English language • Adult patients … Two independent reviewers assigned a quality rating for each study. … Generally, a good-quality study met all major criteria. … studies were quite small and had brief study periods.
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
    January 01, 2017 - Risk-of-bias ratings for each study are in Appendix F of the full report. … No comparative study reported deaths. Meta-analysis of PTH-related data. … Group differences were not statistically significant in the electrocautery study. … Understanding of “obstructive sleep-disordered breathing” varied from study to study as did degree … Morbidity in patients waiting for tonsillectomy in Cardiff: a cross-sectional study.
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
    January 01, 2010 - OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting … Risk of bias speaks to the internal validity of a study. … Refocus the study question on gaps in trial evidence. … without detailed review of each study. … question, study design, and the treatments under review.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/selecting-evidence.ppt
    January 01, 2010 - OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting … Risk of bias speaks to the internal validity of a study. … Refocus the study question on gaps in trial evidence. … without detailed review of each study. … question, study design, and the treatments under review.
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research.pdf
    September 01, 2014 - Study inclusion criteria Category Criteria for Inclusion Study enrollment Studies that enroll adults … Not eligible study design Yamanishi T, Yasuda K, Kamai T, et al. … Not eligible study design Lukkarinen O, Hellstrom P, Leppilahti M, et al. … Study and patient characteristics appear in Table H1. … Only one study reported a primary outcome (Table H7).
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
    October 01, 2010 - This study was not referenced for the right purpose. … was good, three studies were fair, and one study was poor.” … 9.8 points 3, 6, and 9 months after the study? … • This study evaluated 105 patients followed for one year. … This study has been included through our update search.
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
    June 15, 2010 - Sample size: There are no restrictions for study sample size. … Key study elements will be reviewed by a second person (study investigator) with respect to study outcomes … study design, sample size, sample size calculation or power estimate); clinical indications; and study … The study design elements evaluated with this tool include: selection of the study population, appropriate … and have been judged to have had an “inadequate response” at the time of entry into the study.
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_executive.pdf
    January 01, 2010 - Inclusion/exclusion criteria Category Criteria Study Population Low-risk pregnant women who have a … They represent 95 distinct study populations. … The most common reasons for exclusion were ineligible study design and irrelevance to the topic. … 1 (168) Moderate N/A Direct Imprecise Insufficient; 1 fair-quality study KQ2. … 1 (201) Moderate N/A Direct Imprecise Insufficient; 1 fair-quality study 11 Table B.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
    December 23, 2014 - Outcomes Mortality Recurrence (study author defined) Clearance (study author defined) Complications … Study inclusion criteria Category Criteria for Inclusion Study Enrollment Studies that enroll adults … We will summarize included study characteristics and outcomes in evidence tables. … design and risk of bias, study limitations will be rated as low, medium, or high. … Study design: prospective, retrospective or mixed?
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
    November 01, 2013 - • Study conduct. … Score as one of three levels, separately by type of study design: • Low level of study limitations … • Medium level of study limitations • High level of study limitations Directness Directness relates … It includes: • Study publication bias, i.e., nonreporting of the full study. … levels of aggregate risk of study limitations based on study conduct; the scores are low, medium, or

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