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evidence gaps listed below, the USPSTF provides guidance to
researchers and funders on the types of studies … Gap‡
Study
Characteristics
Population
Intervention/
Comparison
Outcomes/ Timing Setting
Studies … KQ2 Indirect Grade
assignment
Randomized
trials, Cross-
sectional and
cohort studies of
diagnostic … KQ2
Direct and
indirect
Grade
assignment
Randomized and
non-randomized
studies
Adults (age … KQ 1,3,4,5
Direct and
indirect
Grade
assignment
Randomized and
non-randomized
studies
Adults
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April 05, 2016 - STUDY SELECTION Two reviewers independently screened abstracts and studies. … , and cohort studies were considered. … studies. … ; however, other studies in-
cluded patient-reported increase in symptoms. … Conducted in Australia,
Sweden for pre-BD studies;
Greece for post-BD.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/child-maltreatment-counseling-2004
March 09, 2004 - There are no studies about harms of screening and interventions. … We excluded studies about patients presenting with trauma. … Six studies met eligibility criteria. … Studies need to consider the influence of observer or surveillance bias. 26 , 41 , 55 In studies of … Case Control Studies
Criteria
Accurate ascertainment of cases?
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary22/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation-september-2015
March 30, 2015 - Although many older observational studies, including uncontrolled and cross-sectional studies, have shown … When good- and fair-quality studies were available, poor-quality studies were excluded. … Due to methodological shortcomings in the studies and differences across studies in design, interventions … or inability to pool studies. … ‡ Some studies are included for >1 KQ.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary10/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication-2009
March 15, 2009 - Only 2 of the 5 studies included women. … We limited our search to English-language studies, human studies, and studies of nonpregnant adults and … We excluded studies of poor quality. … We ultimately included 4 studies, which we discuss. … criteria, or standard appraisal of studies.
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March 01, 2009 - Only 2 of the 5 studies included women. … We limited our search
to English-language studies, human studies, and studies of
nonpregnant adults and … We excluded studies of poor
quality. … We ultimately included 4 studies, which we dis-
cuss. … criteria, or standard appraisal of studies.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/LSbrGFWSvekVzhcxwjTuXv
February 01, 2016 - Studies most clinically relevant to practice in
the United States were selected over studies that were … designed as RCTs, cohort studies,
case–control studies, and systematic reviews; criteria to
rate other … Observational Studies
Three good-quality systematic reviews of observa-
tional studies of screening … Observational Studies
Five case-series studies compared breast cancer
diagnoses in populations of women … based on 7 case–
control studies.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/genital-herpes-screening-november-2016
August 06, 2015 - Analytic Framework
*Studies … † Eligible studies with mixed populations (e.g., studies that enroll a subset of participants who … ‡ Studies that test for both HSV-1 and HSV-2 (simultaneously) will not be excluded if they meet the … are no exclusion criteria for the date of publication for eligible studies for KQs 2 and 3. … If a recent good-quality systematic review is identified, relevant primary studies published since the
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April 17, 2018 - Random-effects meta-analysis used
when at least 3 similar studies were available. … lists of pertinent
articles, and studies suggested by reviewers, were reviewed. … Characteristics of included studies
are reported in Table 1. … in only 2 studies. … and osteoporotic fractures in most studies.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan104/skin-cancer-screening-july-2016
July 17, 2014 - Evidence-based Practice Center will use to search for publications and to determine whether identified studies … of doctor-patient relationship quality
Study design
Fair- to good-quality studies … , including cohort and case-control studies; ecologic studies
KQs 2, 6: Same as above, as well … as case series on the harms of screening
Poor-quality studies with a fatal flaw; studies outside … The USPSTF also refined the search window to include studies published between January 1, 1995 and March
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-pregnant-women/human-immunodeficiency-virus-hiv-infection-screening
June 15, 2017 - similar to that in the United States, except for randomized trials of antiretroviral therapy
Studies … of screening conducted in low and middle-income countries, unless fair- or good-quality studies in the … or were previously taking antiretroviral therapy prior to pregnancy; women with acute HIV infection; studies … outcomes
Study designs
KQs 1–4: Randomized, controlled trials and controlled observational studies … KQ 5: Randomized trials and controlled observational studies
KQs 1–4: Modeling studies
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July 01, 2009 - In addition, studies not published
in English and studies of community- or home-based screening
were … ( n = 2)
Catarac t
RCT s ( n = 2)
SR (of observational studies )
( n = 1)
Observational studies … We excluded studies of strictly
community- or home-based vision screening but in-
cluded mixed studies … 8 studies of diagnostic
accuracy
Fair Methodological shortcoming
in trials; no studies
assessed accuracy … of LASIK;
keratitis rates range from 0% to 3.4% in
6 studies of LASIK and 4 studies of
LASEK
AMD �
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September 06, 2016 - 0.90 (57 studies; n = 4378). … For harms of treatment (KQ5), prospective co-
hort studies and case-control studies were also eligible … .73-75 In 3 studies,
fewer than 25% of the participants were BCG vaccinated.28,30,72
Thirteen studies … 0 Studies included for KQ1 0 Studies included for KQ43 Studies included for KQ3 5 Studies included … less than 5% in 9 studies,64,65,77,78,80,82-85 and not reported in 5
studies.73,79,86-88 Pooled estimates
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December 01, 2007 - In
general, studies were selected if they were large, multi-
institution, prospective studies that reported … Thirteen observational studies were sec-
ondary analyses of administrative databases: 2 studies used … The studies included patients who did
and did not have neurologic symptoms, but we reviewed
only studies … Six of the studies collected informa-
tion on race; in those studies, most participants were white
(range … The systematic review of 103 studies found an overall
stroke and death rate at 30 days of 3.0% in studies
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/8dzfZ_s3tZueoEh5Xzh-3A
July 26, 2016 - studies were
included for all key questions. … For
studies focusing on morbidity and mortality, studies of skin cancer
mortality, all-cause mortality … For studies on early detection of skin cancer, studies that
evaluated either American Joint Committee … ; poor-quality studies were ex-
cluded. … Consistency
among studies
was high.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/827CwGYMVawpVoVg_syJpF
October 01, 2015 - Several studies reported inconsistent findings on these
health outcomes. … Change in Iron Status
No studies were found that directly assessed the
association between change in … Studies used varying doses of iron, ranging from 20 to
200 mg per day. … These studies assess the effects of the preventive service on health
outcomes. … This conclusion is therefore unlikely to be strongly affected by the results of future studies.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/6-CojmU4NZFXUKggs-_YFU
January 01, 2010 - There was no
significant difference in the results when poor studies
were excluded. … Breastfeeding intervention studies often
combined interventions. … Main Effects (Meta-regression) Combined Effects
Education
Studies Education Support Studies Plus Support … ,61 their impact in studies
of clinic-based behavioral counseling is uncertain. … , all
studies were pooled to display mean differences and
confidence boundaries.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/72ybMHDdg9WyFzrYMBF4ch
August 01, 2015 - However, the USPSTF found no
studies on these harms. … Studies on
the potential harms of screening and
interventions are also needed. … The review
excluded studies that focused on
acquired, focal causes of speech and
language delay. … The majority of
studies included 2- and 3-year-olds,
but the ages varied. … ;
however, individual studies used
different reference standards.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/-YHCmR_8bdShSaMTx6Mrgx
ambulatory adults
age 65 years or older
N/A Falls Settings
applicable to
U.S. primary
care
Studies … nursing
or care homes, or
other long-term
care facilities)
KQ 2: Harms outcomes
as reported in studies … Studies are needed on the effectiveness and
harms of interventions in different functional and
risk … More studies are needed on the benefits and
harms of educational and psychological
interventions … Outcomes/
Timing Setting
education via
written materials,
video, or lecture) or
usual care
Studies
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary45/skin-cancer-counseling-2012
May 15, 2012 - For key questions 4 and 5, we included trials, cohort studies, and population-based case-control studies … The ORs and risk ratios, however, should not be compared between studies because the studies used very … These studies showed mixed results: two studies found a statistically significant association between … Four of 5 studies used only a crude dichotomous measure of indoor tanning, and none of these studies … comparisons across studies.