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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
    January 01, 2024 - of children o Parallel or cross-over RCTs  n ≥25/group* o Nonrandomized comparative studies  … Must account for potential confounders  n ≥50/group* Key Question 2 • Studies of adults o … For studies of omega-3 fatty acids (n-3 FA), we will rely on the studies identified for our 2016 systematic … Data Extraction and Data Management Data from eligible studies will be extracted into SRDR+. … ROBINS-I: a tool for assessing risk of bias in non- randomised studies of interventions.
  2. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
    May 01, 2005 - For some studies, all outcomes may have the same sources of bias; for other studies, the sources of … clinical trials, prospective or retrospective cohort studies, and case-control studies) in the ROBINS-I … It excludes case studies, case series and cross-sectional studies, although some systematic reviews … dIncludes nonrandomized controlled studies with investigator-allocated treatment and observational studies … or a body of studies.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
    June 01, 2023 - Most studies on interventions to treat bereaved individuals, however, are small pilot studies.29 There … comparing two or more intervention cohorts, controlled post-only studies, and case-control studies … comparing two intervention cohorts, controlled post-only studies, and case-control studies. … Studies), QUADAS 2 (Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies), and RoB … studies that can strengthen evidence statements through confirmation of results in strong studies.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hro-protocol.pdf
    January 01, 2023 - To streamline data extraction, we will sort eligible studies by specific PSP (if the report covers … • Poor - Outdated, irrelevant, or biased review without systematic search for studies, explicit … selection criteria, or standard appraisal of studies. … ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. … Criteria for assessing internal validity of individual studies [Internet]. Rockville (MD): U.S.
  5. effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-outpatient-setting-comments.pdf
    March 22, 2021 - at all, and that some studies conducted subgroup analysis on this variable and others did not. … These studies could compare surveillance methods or to no monitoring. … We initially hoped to be able to conduct subgroup analyses based on US vs. non-US studies. … Ultimately, we did not have enough studies for a given comparison to do that. … Removing all non-US studies would lead to insufficient evidence across the board.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-mental-health-protocol-amendment.pdf
    January 22, 2024 - ● Cohort studies ● Randomized controlled trials (RCTs) ● Non-randomized comparative studiesstudies ● RCTs ● Non-randomized comparative studies o Non-randomized controlled trials o Observational … cohort studies with a comparison group o Pre-post studies Implementation studies without a comparison … We will include filters to remove nonhuman studies and articles that are not primary studies or systematic … be screened for additional eligible studies.
  7. effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
    June 09, 2021 - Subgroup analysis comparisons across studies were not possible when studies did not report the same … Please be accurate about including cohort studies (I was confused whether cohort studies were only … TEP #1 Results Page 21 it states: Four studies reported on cognitive function.82, 88, 95, 161 Studies … Under Appendix C, detailed results were presented for included studies, the effect size if studies … Five studies were identified and cited, but two of the studies could not be included in the overall
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - , not diagnostic, individual-level, or observational studies Background • Quantitative synthesis … be combined with cluster- randomized studies? … ► Cherry-picking studies to include in meta-analysis can introduce bias. … The Impact of Study Size on Meta-analyses: Examination of Underpowered Studies in Cochrane Reviews. … The Impact of Study Size on Meta-analyses: Examination of Underpowered Studies in Cochrane Reviews.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
    December 31, 2022 - For some factors that varied within studies or were specific to certain studies (including demographic … sizes for the available studies were not large. … Future Research and Ongoing Studies Longer followup from the included studies should assess whether … Control for demographic characteristics and other confounders varied across studies, and studies additionally … Ongoing Studies Appendix E.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
    July 19, 2023 - comparing two cohorts, controlled post-only studies, and case-control studies. … We will differentiate short-term and long-term outcomes for all studies. … For the diagnostic studies, we will apply criteria consistent with QUADAS-2. … studies that can strengthen evidence statements through confirmation of results in strong studies. … We will stratify key question 1 (diagnosis) by studies evaluating first-time diagnosis versus studies
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
    June 21, 2019 - Study design: • Include for all KQs: Clinical trials and observational studies (cohort studies and … case-control studies) … studies … published since 2014 for pearling of studies • Potentially include pre-post studies in the absence … of clinical trials and controlled observational studiesStudies with the following sample sizes
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
    January 01, 2024 - of adults o Parallel or cross-over randomized controlled trials (RCTs)  n ≥25/group* • Studies … of children o Parallel or cross-over RCTs  n ≥25/group* o Nonrandomized comparative studies  … Key Questions • Observational studies that do not account for confounders • Analyses of dietary … Data Extraction and Data Management Data from eligible studies will be extracted into SRDR+. … ROBINS-I: a tool for assessing risk of bias in non- randomised studies of interventions.
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
    April 01, 2020 - For the studies that addressed the subgroup KQs (KQs 1b, 2b, 3b, 4b, 5b), we only included studies … We found no studies for KQ 4. … Key characteristics of included studies Study Characteristics Subcharacteristics Number of Studies … 34 56.7 High risk-of-bias studies 25 41.7 Study quality for harms Low risk-of-bias studies 1 1.7 Some … concerns for risk-of-bias studies 23 38.3 High risk-of-bias studies 14 23.3 Unclear risk of bias 1 1.7
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-pregnant-protocol.pdf
    August 24, 2023 - We will not exclude studies based on their duration. … • EXCLUDE: Single group (noncomparative) studies, including case reports or series • EXCLUDE: Studies … for studies in the appendix evidence map. … For studies meeting criteria for full data synthesis (and for other large studies [N≥100 per group … for studies in the appendix evidence map.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
    January 01, 2024 - c (n) = number of studies reporting this characteristic at baseline. … ) [SOE] Pain Severity Effect Size (N Studies) [SOE] Function Effect Size (N Studies) [SOE] … ) [SOE] SAE Effect Size (N Studies) [SOE] Dizziness Effect Size (N Studies) [SOE] Nausea … Effect Size (N Studies) [SOE] Sedation Effect Size (N Studies) [SOE] Comparable THC/CBD – … in the United States, studies on long-term outcomes, studies on nonneuropathic chronic pain, studies
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
    May 19, 2020 - • Animal studiesStudies with patients under 18 years of age • Mixed population - Less than … studies that do not report the outcomes of interest … Studies of Interventions (ROBINS-I tool). … We will conduct meta- analyses when there are sufficient data (at least two studies) and studies are … RCTs and other intervention studies with a comparison group will be analyzed separately.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
    January 01, 2023 - These evidence gaps can inform future research studies, the findings from which can improve clinical … Interventions • Studies of high THC to CBD ratio products derived from whole-plant cannabis, with … • Only a small number of studies have evaluated opioids. … • Studies in underserved populations and equity in program delivery. … • Studies comparing programs with pharmacologic treatments.
  18. effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
    November 01, 2020 - • Studies showed no difference in effectiveness between different doses or routes of administration … Strengths and Limitations We identified numerous studies evaluating a variety of nonpharmacological … However, sample sizes were small, followup was short term, most studies only used visual analog scales … Most studies included patients with lung cancer and chronic obstructive pulmonary disease, but we were … Opioids and anxiolytics were not effective, although studies were limited, and few studies evaluated
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-disposition-comments.pdf
    May 22, 2023 - representativeness of the populations studies. … Vitamin C studies do not provide great profits. … We suspect that observational studies are likely to face similar challenges. … We note the role of observational studies in future work in the discussion. … We suspect that observational studies are likely to face similar challenges.
  20. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol-amendment.pdf
    August 10, 2022 - Studies of at least 10 patients per treatment arm GENERAL • Dosimetry modeling studies • Non-human … studies • NRSI for effectiveness if RCTs are available • Studies with <10 patients per arm • … Single arm studies (unless no comparative studies); if used, exclude studies of <10 patients • … In the absence of comparative studies, single arm (e.g., case series, pre-post studies) with at least … from poorer- quality studies.

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