-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
January 01, 2024 - of children
o Parallel or cross-over RCTs
n ≥25/group*
o Nonrandomized comparative studies
… Must account for potential
confounders
n ≥50/group*
Key Question 2
• Studies of adults
o … For studies of omega-3 fatty acids (n-3 FA), we will rely on the studies identified for our
2016 systematic … Data Extraction and Data Management
Data from eligible studies will be extracted into SRDR+. … ROBINS-I: a tool for assessing risk of bias in non-
randomised studies of interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
May 01, 2005 - For some studies, all outcomes
may have the same sources of bias; for other studies, the sources of … clinical trials, prospective or
retrospective cohort studies, and case-control studies) in the ROBINS-I … It
excludes case studies, case series and cross-sectional studies, although some systematic reviews … dIncludes nonrandomized controlled studies with investigator-allocated treatment and observational studies … or a body of studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
June 01, 2023 - Most studies on
interventions to treat bereaved individuals, however, are small pilot studies.29 There … comparing two or more
intervention cohorts, controlled post-only studies, and
case-control studies … comparing two intervention cohorts, controlled post-only
studies, and case-control studies. … Studies), QUADAS 2 (Revised Tool for the Quality Assessment of
Diagnostic Accuracy Studies), and RoB … studies that can strengthen evidence statements through confirmation of
results in strong studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hro-protocol.pdf
January 01, 2023 - To streamline data extraction, we will sort eligible studies by
specific PSP (if the report covers … • Poor - Outdated, irrelevant, or biased review without systematic search for
studies, explicit … selection criteria, or standard appraisal of studies. … ROBINS-I: A tool for assessing
risk of bias in non-randomised studies of
interventions. … Criteria for assessing internal validity of
individual studies [Internet]. Rockville
(MD): U.S.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-outpatient-setting-comments.pdf
March 22, 2021 - at all, and that some studies conducted subgroup analysis on
this variable and others did not. … These studies could compare surveillance
methods or to no monitoring. … We initially
hoped to be able to conduct subgroup
analyses based on US vs. non-US studies. … Ultimately, we did not have enough studies for
a given comparison to do that. … Removing
all non-US studies would lead to insufficient
evidence across the board.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-mental-health-protocol-amendment.pdf
January 22, 2024 - ● Cohort studies
● Randomized controlled trials
(RCTs)
● Non-randomized comparative
studies … studies
● RCTs
● Non-randomized comparative studies
o Non-randomized controlled trials
o Observational … cohort studies with a comparison group
o Pre-post studies
Implementation studies without a comparison … We will
include filters to remove nonhuman studies and articles that are not primary studies or systematic … be screened for additional eligible studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
June 09, 2021 - Subgroup analysis
comparisons across studies were
not possible when studies did not
report the same … Please be accurate about including
cohort studies (I was confused whether cohort
studies were only … TEP #1 Results Page 21 it states: Four studies reported on
cognitive function.82, 88, 95, 161 Studies … Under
Appendix C, detailed results were presented for
included studies, the effect size if studies … Five studies were identified and
cited, but two of the studies could
not be included in the overall
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
July 01, 2019 - , not diagnostic, individual-level, or
observational studies
Background
• Quantitative synthesis … be combined with cluster-
randomized studies? … ► Cherry-picking studies to include in meta-analysis can introduce
bias. … The Impact of Study Size on Meta-analyses: Examination of Underpowered Studies in Cochrane Reviews. … The Impact of Study Size on Meta-analyses: Examination of Underpowered Studies in Cochrane Reviews.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
December 31, 2022 - For some factors that varied within studies or were specific to certain studies (including demographic … sizes for
the available studies were not large. … Future Research and Ongoing Studies
Longer followup from the included studies should assess whether … Control for demographic characteristics and other confounders varied across studies, and
studies additionally … Ongoing Studies
Appendix E.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
July 19, 2023 - comparing two
cohorts, controlled post-only studies, and case-control
studies. … We will differentiate short-term and
long-term outcomes for all studies. … For the diagnostic studies, we will apply criteria consistent with QUADAS-2. … studies that can strengthen evidence statements through confirmation of
results in strong studies. … We will stratify key question 1 (diagnosis) by studies
evaluating first-time diagnosis versus studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
June 21, 2019 - Study design:
• Include for all KQs: Clinical trials and observational studies (cohort studies and … case-control studies) … studies … published since 2014 for pearling of
studies
• Potentially include pre-post studies in the absence … of
clinical trials and controlled observational studies
• Studies with the following sample sizes
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
January 01, 2024 - of adults
o Parallel or cross-over randomized
controlled trials (RCTs)
n ≥25/group*
• Studies … of children
o Parallel or cross-over RCTs
n ≥25/group*
o Nonrandomized comparative studies
… Key Questions
• Observational studies that do not account
for confounders
• Analyses of dietary … Data Extraction and Data Management
Data from eligible studies will be extracted into SRDR+. … ROBINS-I: a tool for assessing risk of bias in non-
randomised studies of interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
April 01, 2020 - For the studies that addressed the subgroup KQs
(KQs 1b, 2b, 3b, 4b, 5b), we only included studies … We found no studies for KQ
4. … Key characteristics of included studies
Study Characteristics Subcharacteristics
Number of
Studies … 34 56.7
High risk-of-bias studies 25 41.7
Study quality for harms Low risk-of-bias studies 1 1.7
Some … concerns for risk-of-bias studies 23 38.3
High risk-of-bias studies 14 23.3
Unclear risk of bias 1 1.7
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-pregnant-protocol.pdf
August 24, 2023 - We will not exclude studies based on their duration. … • EXCLUDE: Single group (noncomparative) studies, including case reports or series
• EXCLUDE: Studies … for studies in
the appendix
evidence
map. … For studies meeting
criteria for full data
synthesis (and for other
large studies [N≥100 per
group … for studies in
the appendix
evidence
map.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - c (n) = number of studies reporting this characteristic at baseline. … )
[SOE]
Pain Severity
Effect Size (N Studies)
[SOE]
Function
Effect Size (N Studies)
[SOE] … )
[SOE]
SAE
Effect Size (N
Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea … Effect Size (N
Studies)
[SOE]
Sedation
Effect Size (N
Studies)
[SOE]
Comparable
THC/CBD – … in the United States, studies on long-term outcomes,
studies on nonneuropathic chronic pain, studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
May 19, 2020 - • Animal studies
• Studies with patients under 18 years of age
• Mixed population - Less than … studies that do not report the
outcomes of interest … Studies of Interventions (ROBINS-I tool). … We will conduct meta-
analyses when there are sufficient data (at least two studies) and studies are … RCTs and other intervention studies with a comparison group will be analyzed
separately.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - These evidence
gaps can inform future research studies, the findings from which can improve clinical … Interventions
• Studies of high THC to CBD ratio products
derived from whole-plant cannabis, with … • Only a small number of studies have evaluated
opioids. … • Studies in underserved populations and
equity in program delivery. … • Studies comparing programs with
pharmacologic treatments.
-
effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
November 01, 2020 - • Studies showed no difference in effectiveness between different doses or routes of
administration … Strengths and Limitations
We identified numerous studies evaluating a variety of nonpharmacological … However, sample sizes were small, followup was short term, most studies only
used visual analog scales … Most studies
included patients with lung cancer and chronic obstructive pulmonary disease, but we were … Opioids and
anxiolytics were not effective, although studies were limited, and few studies evaluated
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-disposition-comments.pdf
May 22, 2023 - representativeness of the
populations studies. … Vitamin C
studies do not provide great profits. … We suspect that
observational studies are likely to face similar
challenges. … We note
the role of observational studies in future work in
the discussion. … We suspect that
observational studies are likely to face similar
challenges.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol-amendment.pdf
August 10, 2022 - Studies of at least 10 patients per treatment arm
GENERAL
• Dosimetry modeling studies
• Non-human … studies
• NRSI for effectiveness if RCTs
are available
• Studies with <10 patients per arm
• … Single arm studies (unless no
comparative studies); if used,
exclude studies of <10 patients
• … In the absence of comparative studies,
single arm (e.g., case series, pre-post studies) with at least … from poorer-
quality studies.