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Total Results: 2,082 records

Showing results for "studies".

1801. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
      December 29, 2015 - However, the experts wanted to see additional clinical studies that compare the efficacy of secukinumab … However, the experts thought that more clinical studies are needed to determine the long-term efficacy … were concerned about the reported adverse events.15,18 Some experts also wanted to see more clinical studies … of patients with complete tophus resolution.28 The most common adverse events reported in the two studies … Novartis AIN457 (secukinumab) meets primary endpoint in two phase III studies in ankylosing spondylitis

1802. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
      July 09, 2013 - Preclinical studies demonstrated that florbetapir was highly specific in binding to beta-amyloid aggregates … completed.12,13 According to a company press release issued in April 2012, a pooled analysis from 4 studies

1803. A Systematic Review of the Processes Used To Link Clinical Trial Registrations to Their Published Results | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/grant-manuscripts/clinical-trial-registrations-abstract

1804. Methods for Evaluating Natural Experiments in Obesity: A Systematic Evidence Review | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/obesity-research-methods/systematic-review

1805. Making Healthcare Safer IV: Programs for Responding to Harms Experienced by Patients During Clinical Care | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/clinical-care/rapid-research

1806. Diabetes Mellitus (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
      December 01, 2015 - Studies have demonstrated that the formulation of exenatide used in ITCA 650 is stable within the Duros … The studies will include a broad range of patients whose diabetes is uncontrolled by oral antidiabetes … In some studies, LAGB has been associated with T2DM resolution (or improvement) in as many as 80% of … BMIs of less than 35 kg/m2 enrolled in 5 randomized controlled trials and 6 observational clinical studies … Also, two pharmacokinetic-pharmacodynamic studies will be initiated to characterize dose response and

1807. Infectious Disease Including HIV/AIDS #09 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
      December 22, 2014 - the manufacturer is not pursuing marketing approval for a dual regimen containing asunaprevir, studies … chronic HCV genotype 1 infection.6 Although the functions of NS5A are not fully defined, in vitro studies … genotype 2 (n=26) and genotype 3 (n=42) achieved SVR12 rates of 88% and 67%, respectively.23 In studies … infections without IFN or RBV, some experts thought.82,83,85,87 Data have been reported from multiple studies … Multiple, ongoing studies with large patient populations were also encouraging, the experts noted.

1808. Disruptive-Behavior-Disorders-Research-App-E (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-research-app-e.xlsx
      January 01, 2022 - Risk of bias assessment for nonrandomized studies of intervention Author, Year Did the Study Attempt

1809. Framework for Considering Study Designs for Future Research Needs | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/study-design-framework/research

1810. Infectious Disease Including HIV/AIDS #09 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
      December 01, 2015 - chronic HCV genotype 1 infection.6 Although the functions of NS5A are not fully defined, in vitro studies … Patients with HCV genotype 2 and 3 infection had SVR12 rates of 88% and 92%, respectively.21 In studies … infections without IFN or RBV, some experts thought.103-105 Data have been reported from multiple studies … Multiple, ongoing studies with large patient populations were also encouraging, the experts noted.

1811. #14 SUBSTANCE ABUSE (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
      January 01, 2012 - The theory underlying the use of a texting platform is based on studies that have shown that (unidirectional … . since its launch in 2010. 2,3 The theory underlying the use of a texting platform is based on studies

1812. Comparative Effectiveness of β-Adrenergic Antagonists on the Risk of Rehospitalization in Adults with Heart Failure (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-rehospitalization_research.pdf
      November 01, 2007 - Previous studies have shown that elderly patients with heart failure are often undertreated, and provision … However, future validation studies of the database algorithm of drug exposure are needed to confirm … However, our results should be interpreted cautiously and additional observational studies as well as … efficacy of multiple β-blockers for heart failure will not be completed in the near term, followup studies … These findings, if confirmed by additional studies and possibly randomized trials that simultaneously

1813. Obesity (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
      June 01, 2014 - This expert also noted that larger and long- term studies are needed to evaluate the safety and efficacy … and a time table for assessments.”37 FDA has required the manufacturer to conduct 10 postmarketing studies … experts expressed concern regarding gastrointestinal side effects and listed a need for long-term studies … With the approval, FDA required that the manufacturer conduct six postmarketing studies, including … For instance, one expert representing a clinical perspective commented, “Published studies have shown

1814. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - apolipoprotein e4 (ApoE4) allele, which is known to be a genetic risk factor for AD.5,8,9 Additionally, studies

1815. Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/outcomes-nutrition/research

1816. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
      January 01, 2012 - However, one clinical expert stated that double-blind studies are needed to compare MSC therapy to … cartilage regeneration, evaluated by magnetic resonance imaging, would need to be shown by these studies … janus kinase inhibitor, in the treatment of rheumatoid arthritis: open-label, long-term extension studies

1817. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
      January 01, 2012 - Reports from observational studies suggested that helminths might prevent or improve UC by inducing … common and that people with helminths have an altered immunologic response to antigens. 2 Preclinical studies … relief at initial followup. 25 POEM has been generally well tolerated according to reports from studies

1818. Cer-276-Ocd-Appendix-G (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-276-ocd-appendix-g.xlsx
      January 01, 2022 - child and adolescent anxiety center at Mayo Clinic + community controls: participated in two previous studies … : We should discuss studies that enroll at least one clinical sample, e.g.

1819. Pharma-Nonpharma-Ptsd-2022-Update-App-G1 (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
      January 01, 2022 - Risk of Bias 2 assessment of new included studies RoB Domain Bias Due to Randomization (Cochrane) or

1820. Diabetes-Foot-Ulcer-Amputation-Prevalence Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-foot-ulcer-amputation-prevalence_research.pdf
      February 01, 2011 - initial observations, algorithm 3, which is consistent with the definition of diabetes in many previous studies