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  1. effectivehealthcare-admin.ahrq.gov/products/child-growth-development-outcomes/protocol
    November 01, 2024 - Studies that exclusively enroll participants hospitalized with an illness or injury Studies designed … and controlled before-and-after studies Cross-sectional studies Case-control studies All other study … The one exception is studies of adolescents; for those meeting all other eligibility criteria, studies … If older, seminal studies or studies cited in the prior guideline are needed for context we will provide … If older, seminal studies or studies cited in the prior guideline are needed for context we will provide
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
    November 01, 2023 - • No new eligible studies were found for disulfiram. … We included all studies in the main analyses and conducted sensitivity analyses without studies rated … Among these, 81 studies (106 articles) were included in the 2014 report and 37 studies (50 articles … Key Question 1 included 111 studies, Key Question 2 included 31 studies, Key Question 3 included 99 … studies, Key Question 4 included 1 study, and Key Question 5 included 9 studies.
  3. effectivehealthcare-admin.ahrq.gov/products/cell-free-dna/draft-report
    January 01, 2025 - Using predefined criteria, two investigators independently selected studies on MCSTs. … No controlled studies evaluated the benefits or harms of screening with MCSTs. … performance studies. … Only English-language studies were included; many accuracy studies were high risk of bias and used diagnostic … studies will be completed in the next 2 to 4 years. 
  4. effectivehealthcare-admin.ahrq.gov/products/risk-cardiovascular-disease/protocol
    December 01, 2023 - opposed to longer term studies Studies that examine food products or dietary supplements not widely … , qualitative studies, cost-benefit analysis, cross-sectional (i.e., nonlongitudinal) studies, survey … journals Studies published at and after the year 2000 Non-English language studies … For nonrandomized studies, including quasi-experimental studies, controlled before-and-after studies, … studies.
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-253-maternal-child-outcomes-wic-executive-summary.pdf
    April 01, 2022 - published since 2009, including studies evaluating outcomes before and after the federal regulatory … Results We found 82 quantitative observational studies, including 49 studies with direct evidence … , and investigator-initiated studies. … The review focused mainly on studies having a comparison group with WIC- eligible non-participants. … For many outcomes, few studies were identified.
  6. effectivehealthcare-admin.ahrq.gov/products/methods-guidance-harms/methods
    May 01, 2020 - Cohort and case-control studies. … Other observational studies. … Two studies found that industry-funded studies tended to report more favorable outcomes than did studies … types of studies. … Review Studies meet certain study design definitions (e.g., cohort and case-control studies) Studies
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-infection-prevention-mdro-rapid-research.pdf
    April 01, 2024 - before-after studies • Interrupted time series studies and repeated measures studies • Discontinuation … or quasi-experimental studies … before-and-after studies. … All studies were before-and-after studies. The synthesis was narrative. … Almost all studies were before-and-after studies.
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/risk-cardiovascular-disease.pdf
    January 01, 2023 - (used for identifying additional studies) • In vitro studies, nonoriginal data (e.g., narrative … Publications • Studies published in English only • Studies published in peer-reviewed journals … • Studies published at and after the year 2000 • Non-English language studies Abbreviations: CVD … For nonrandomized studies, including quasi-experimental studies, controlled before-and-after studiesstudies.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/selecting-evidence-quiz.ppt
    September 02, 2013 - Using Observational Studies in Comparative Effectiveness Reviews Using Observational Studies in Comparative … Using Observational Studies in Comparative Effectiveness Reviews Using Observational Studies in Comparative … Observational Studies and Applicability of the Comparative Effectiveness Review Observational Studies … When Observational Studies Are Needed When Observational Studies Are Needed Once gaps in the trial … Case reports Cross-sectional studies Cohort and case-control studies What Types of Observational Studies
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/selecting-evidence-quiz.ppt
    September 02, 2013 - Using Observational Studies in Comparative Effectiveness Reviews Using Observational Studies in Comparative … Using Observational Studies in Comparative Effectiveness Reviews Using Observational Studies in Comparative … Observational Studies and Applicability of the Comparative Effectiveness Review Observational Studies … When Observational Studies Are Needed When Observational Studies Are Needed Once gaps in the trial … Case reports Cross-sectional studies Cohort and case-control studies What Types of Observational Studies
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
    September 24, 2024 - • Retrospective comparative studies • Case control studies • Before/after studies • Time series … Studies for CQ1 will come from two sources: (1) quantitative studies included in the review for KQ1– … We will not exclude studies rated high risk of bias a priori, but high risk of bias studies will be … Our approach to describing the quality of the included studies will be driven by the volume of studies … (e.g., surveys, qualitative studies, descriptive studies).
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-draft-report.pdf
    January 31, 2025 - Meta-analyses were not conducted due to limited data and heterogeneity of studies; included studies … Excluded Studies List Appendix F. … studies • Case-control studies • All other study designs Geographic Location • Locations with … (for comparative studies). … • Five of the six studies were not designed to answer this question; four were studies of dietary
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/high-risk-drugs-protocol.pdf
    July 27, 2023 - Eligibility Criteria for Studies of Effectiveness We will search for original studies and systematic … Type of studies All RQs: Systematic reviews. … Description of Included Studies To efficiently describe eligible studies, the full text of each potentially … criteria, or standard appraisal of studies. … Criteria for assessing internal validity of individual studies. U.S.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fatigue-sleepiness-protocol.pdf
    July 01, 2023 - Eligibility Criteria for Studies of Effectiveness We will search for original studies and systematic … Description of Included Studies To efficiently describe eligible studies, the full text of each potentially … the findings of those studies. … criteria, or standard appraisal of studies. … Eligibility Criteria for Studies of Effectiveness We will search for original studies and systematic
  15. effectivehealthcare-admin.ahrq.gov/products/liver-cancer/research-protocol
    December 01, 2019 - , and other observational studies. … Case-control studies, case studies, literature reviews Studies that do not report sensitivity, cost … Case-control studies, case studies, literature reviews Studies that do not report sensitivity, cost … Case-control studies, case studies, literature reviews Studies that do not report sensitivity, cost … Studies of treatment response Studies looking at liver metastases Studies with imaging conducted
  16. effectivehealthcare-admin.ahrq.gov/products/opioids-older-adults/report
    January 01, 2022 - associated with opioid-related outcomes and 16 studies of interventions in older adults. … Alcohol misuse and gender were variably associated with opioid misuse (examined by three studies each … Across 6 studies evaluating opioid-related disorders, including OUD and opioid misuse, 3 studies each … Only 2 studies were randomized controlled trials. … Each intervention was evaluated by one, or in two instances, two studies.
  17. effectivehealthcare-admin.ahrq.gov/products/autism-adolescents/research
    December 01, 2019 - Review Methods We included studies published in English from January 1980 to December 2011. … Results We identified 32 unique studies, most of which were poor quality. … Five studies, mostly of medical interventions, were fair quality, and none were good. … with some positive results in studies typically of short duration. … Five studies, primarily of medical interventions, had fair quality.
  18. effectivehealthcare-admin.ahrq.gov/products/appendicitis/research
    December 01, 2019 - meeting our criteria for cohort studies that reported information on test accuracy for the diagnosis … of acute appendicitis or harms, and for comparative studies (randomized or nonrandomized) that reported … ; we also extracted data in duplicate for a sample of noncomparative studies. … symptoms and signs (137 studies), laboratory tests (217 studies), imaging tests (519 studies), multivariable … diagnostic scores (127 studies), and diagnostic laparoscopy (55 studies).
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs-iv-nv-hap-protocol.pdf
    August 05, 2024 - If multiple SRs include the same studies and relevant unique studies, we will use the most comprehensive … and rate the risk of bias for individual studies. … in each arm • Nonrandomized comparative studies, including pre-post studies, with ≥100 patients in … each arm • Cross-sectional studies • Case series • Case reports Publication Year • Original studies … criteria, or standard appraisal of studies.
  20. effectivehealthcare-admin.ahrq.gov/products/vitamin-d-calcium/research-protocol
    December 01, 2019 - With the exception of studies of older adults, studies in which more than 20 percent of the participants … For studies of older adults, studies that exclusively enroll subjects with particular diseases (e.g., … before that of the outcome(s)); and prospective nested case-control studies (case-control studies nested … Excluded studies will be cross-sectional studies and traditional, retrospective case-control studies … The forms will be piloted with 10 randomly selected studies (five RCTs and five observational studies

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