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effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
September 30, 2010 - The FDA defines nonimplantable electrical incontinence devices as non significant risk
devices. … injectable bulking
agents for incontinence; and mechanical/hydraulic urinary incontinence devices as significant … Thus, we will monitor all databases for adverse effects from significant risk
devices.
II. … These studies have significant flaws that imply biases of
various types that may invalidate the results
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
November 24, 2014 - Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia
Comparative Effectiveness Review Disposition of Comments Report
Research Review Title: Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic
Treatment for Noso…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
October 12, 2015 - There may be significant variation in outcomes of different treatments in specific
subpopulations. … variation in the degree of coverage
for infertility diagnosis and treatment, and many patients face significant … There were
no other significant changes to the KQs or proposed methods. … These studies had significant flaws that might have
invalidated the results.
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digital.ahrq.gov/sites/default/files/docs/citation/cds-connect-year2-final-report-2018.pdf
January 01, 2018 - Stakeholder Engagement
Significant outreach took place across the CDS Connect project that influenced … MITRE expended
significant effort to align standards and re-purpose previous investments from U.S. … It may be of significant interest to health IT vendors and clinical
organizations that do not have this … The integration of the SMART on FHIR app required a significant level of coding and
mapping from OCHIN … In addition, a significant amount of mapping
was required to ensure capture of the appropriate data.
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www.ahrq.gov/sites/default/files/2024-01/gallagher1-report.pdf
January 01, 2024 - This investment in
a core trainer team created significant buy-in for the organization and external … First, the organizations have a long way to go to achieve
significant change. … Respondents had
significant experience, with an average of 16.1 years in their specific organization … The result was a significant delay in
routing any case to the CRP. … However, we encountered
significant difficulties carrying out the other components of the evaluation
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effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Overall, experts commenting on this intervention felt that it
creatively and effectively addressed a significant … Experts stated that SPARX could positively improve patient health outcomes without
placing significant … minimize severe risk of patient self-harm.1,2
Additionally, many common treatments for MDD and BPD have significant … (64% versus 28%).18
For treating patients with BPD, intravenous ketamine was reported to produce significant … clinical trial (n=52) with patients who had MDD or BPD suggested that
intravenous scopolamine had significant
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/breast-cancer-screening-january-2016
January 11, 2016 - determine the degree to which the additional cases of cancer detected would have become clinically significant … cannot determine whether all of the additional cases of cancer detected would have become clinically significant … who develop breast cancer have a mother or sister who also has breast cancer. 2
A few clinically significant … A significant reduction in advanced disease was not observed with the use of screening mammography in … Neither found significant differences in breast cancer size or node status at the time of diagnosis.
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary16/coronary-heart-disease-screening-using-non-traditional-risk-factors-2009
October 15, 2009 - the Rotterdam cohort aged 62–85 y had CAC scores >400. 41 ¶
Lipoprotein(a) level
6
Some
Significant … Fair
-
-
-
Periodontal disease
1
Some
Significant uncertainty
Sparse or imprecise … Poor
-
-
Men, 3.3%; women, 10%
Carotid intima–media thickness
3
Serious **
Significant … We found significant statistical heterogeneity across studies that was not explained in subgroup analyses … An ABI less than 0.9 is the cutoff point commonly used to indicate possible significant compromise of
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effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - The study has significant flaws that imply biases of various types that may invalidate its
results; … and there is potential for selective
outcome reporting, misclassification, and failure to capture significant
-
www.ahrq.gov/sites/default/files/wysiwyg/pqmp/measures/chronic/chipra-240-bmi-parent-full-report.pdf
February 01, 2020 - Prevalence of Obesity and Unhealthy Weight in Children
Significant increases in the prevalence of childhood … A 2011 systematic
review reports a significant association between child and adolescent overweight/obesity … Childhood obesity
contributes to a significant and increasing burden of chronic disease, rising healthcare
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
July 01, 2013 - for decisionmakers, benefits and
harms for individual LTC recipients, and high costs
Represents a significant … populations, or ethical, legal, and social issues pertaining to
the form of LTC delivery
Potential for significant … health impact
o To improve health outcomes
o To reduce significant variation related to quality of … care
o To reduce unnecessary burden on those with health care problems
Potential for significant
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hcup-us.ahrq.gov/reports/race/R_E_Disparities_rpt.jsp
July 01, 2016 - States Increasingly Turn to the Topic of Costs of Disparities
"The costs to the health system are significant … Kaiser Permanente provided significant financial support for Colorado’s health disparities report. … previously noted, the Patient Protection and Affordable Care Act (ACA) includes provisions that could have a significant
-
www.ahrq.gov/sites/default/files/wysiwyg/pqmp/measures/perinatal/chipra-0085-fullreport.pdf
December 31, 2015 - The PCPI recognizes that EHRs are the state of the art for clinical encounters and is
focusing significant … This is an important area of focus for measurement and provides a
significant area for quality improvement … These data show that a substantial number of pregnant women screened in obstetric
settings have significant … with a minimum number of
events reduces the bias introduced by the inclusion of physicians without a significant
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/abTWXPvJyAMcqN9KcEt-vt
September 06, 2016 - Results for benefits and harms of treatment (KQ3 and
KQ5) were considered statistically significant if … rifampin)95; and 0.0%
(isoniazid) and 1.1% (rifampin).98 The pooled estimate found no sta-
tistically significant … gastrointesti-
nal adverse events were reported among the 3 studies; various other
harms were reported, but no significant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-databases-methods_research.pdf
May 01, 2008 - with the disease
(based on the assumption that neither method of case ascertainment is subject to significant … the manufacturer of donepezil did report in March 2006
about a higher number of deaths (although not statistically … significant) in the treatment arm of a
study in vascular dementia. 27
At the time of the study (2002
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
June 06, 2017 - researchers define improvement as a
decrease in the amount of UI based on objective tests, including any statistically … significant decrease in the frequency of UI episodes (which may not always translate into
clinically … Thus, treatment success and failure should be
evaluated according to what women report to be significant
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/WYvNt2GWJf8uGcAm3p_PFJ
October 05, 2021 - was associated with
an increased risk of preeclampsia, although the finding was not sta-
tistically significant … -
ference [ARD], 5.3%; 3 trials) and preterm deliveries, although find-
ings for the latter are not statistically … significant (RR, 0.75 [95% CI,
0.56-1.01]; ARD, 2.3%; 4 trials).29,34 Treatment of gestational dia-
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/multinational-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - timelines, and cost of the study.
3
Multinational Registries: Challenges and Opportunities
Significant … Differences in diagnostic criteria and/or
screening rates across countries can result in significant … breast or
prostate cancer screening procedures often diagnose these cancers at later stages leading to
significant … Patient Perspectives
In recent years, significant attention has been paid to increasing patient-centeredness
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/G9P7o8jDh4J3NnAk6y-SYL
December 01, 2011 - The other found no statistically significant effect
after 10 years (relative risk, 1.1 [CI, 0.80 to 1.5 … significant differ-
ence in prostate cancer–specific mortality (RR, 0.85 [CI,
0.73 to 1.0]). … significant effect of
screening on prostate cancer–specific mortality (RR, 0.84
[CI, 0.70 to 1.01]), … Screening based on PSA identifies additional cases of pros-
tate cancer, but most trials found no statistically … significant
effect on prostate cancer–specific mortality.
-
digital.ahrq.gov/sites/default/files/docs/citation/r21hs023395-kent-final-report-2017.pdf
January 01, 2017 - accounts for
38% of post-operative complications.1,2 SSI results in physical and emotional stress for a significant … evaluate associations between the components of wound image quality.33 All correlations were
high and significant … Such a program is easily integrated into existing service lines and
does not add a significant additional