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www.uspreventiveservicestaskforce.org/uspstf/document/other-supporting-document19727/drug-use-illicit-primary-care-interventions-for-children-and-adolescents
September 03, 2020 - Across all 29 trials, only 1 trial reported on harms and found no statistically significant group differences … All significance testing was 2-sided, and P ≤ .05 was considered statistically significant. … Despite the small pooled result, some interventions did show statistically significant reductions in … Pooled effects for alcohol and tobacco use both showed statistically significant, but very small, pooled … significant increases in drug use outcomes, and others reported statistically nonsignificant increases
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary26/tobacco-use-in-children-and-adolescents-primary-care-interventions-2013
December 11, 2012 - Results were somewhat variable, with larger studies suggesting either a statistically significant benefit … We found a statistically significant reduced relative risk for smoking initiation among young persons … significant. … significant. … Combined behavioral interventions failed to show a statistically significant effect on overall smoking
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary45/skin-cancer-counseling-2012
May 15, 2012 - The differences in these scores, although statistically significant, were small, and it is unclear whether … These studies showed mixed results: two studies found a statistically significant association between … Of the 4 studies that found a statistically significant association between indoor tanning exposure and … Two studies conducted in Sweden found a statistically significant harmful effect of sunscreen, such that … significant difference, OR not reported
Age ≥14 y
Not statistically significant, OR not reported
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/healthy-diet-and-physical-activity-counseling-for-cvd-prevention-in-adults-2012
December 15, 2010 - Reductions in blood pressure were still statistically significant, although slightly attenuated, at up … There was no statistically significant increase in high-density lipoprotein cholesterol levels. … We found no evidence of statistically significant publication bias for any of the intermediate outcomes … The Egger test of small study effects was statistically significant for the medium-intensity trials; … No statistically significant changes were seen for HDL cholesterol or triglycerides.
3.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/hKRZFsG6c7Kq5ef32cCXa3
February 12, 2019 - statistically significant group dif-
ferences.7,8,11,39,40 Counseling interventions were associated … Two trials50,51 found statistically significant reductions in
depression symptoms (weighted mean difference … , −3.45 [95% CI,
−4.99 to −1.91]),2 although pooled analysis failed to demonstrate
statistically significant … significant or near-significant reductions in
symptom severity scores at 1 (but not all) of several … significant reductions in depres-
sion status or depression symptom scores.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/LU_2NqdYKvadBZuYjUmKo5
April 10, 2018 - Statistically significant
reductions in all-cause hospitalization, average number of hospital
days, and … Only 2 studies that reported outcomes within 2 years of inter-
vention noted statistically significant … and externalizing (disruptive, aggressive, or delinquent)
behavioral outcomes (3/6 trials reported statistically … statistically significant improvements in devel-
opmental outcomes),34 and other measures of abuse and … neglect
(1/2 trials reported statistically significant reductions in abuse and
neglect findings).35
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/kHDoNjsfLx9SyKGD5n2ufL
January 01, 2020 - All significance testing was 2-sided, and results were consid-
ered statistically significant if the … there
was no statistically significant between-group difference in the rates
of otitis media (43.6% … The pooled RR for exclusive breastfeeding for less than 3 months
was also statistically significant ( … When pooled, the as-
sociation was not statistically significant but did not rule out poten-
tial benefit … This updated review failed to find a statistically
significant relationship between individual-level
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/8YfPLRoMwTeaDgxJdYnYbb
September 24, 2019 - Limited
evidence on harms of screening or treatment was available, and no statistically significant
differences … A statistically significant reduction in the risk of low birth
weight was reported in 2 studies,20,24 … and the pooled estimate was
also statistically significant, with low statistical heterogeneity (pooled … significant studies and a no longer significant pooled effect (pooled
RR, 0.86 [95% CI, 0.57-1.31]). … Probably reflecting small
sample sizes, none of the studies reported statistically significant ef-
fects
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hepatitis-b-virus-infection-screening
December 15, 2020 - For HBV DNA suppression, there were statistically significant interactions between geographic region, … For normalization of ALT levels, there was a statistically significant interaction between HBeAg status … Subgroup analyses found no statistically significant interactions between HBeAg status or duration of … Antiviral Therapy vs Placebo or No Treatment
There were no statistically significant differences between … However, results were not statistically significant in all studies.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/hypertensive-disorders-pregnancy-screening
September 19, 2023 - None of the trials reported statistically significant differences across various serious health outcomes … The difference between groups was not statistically significant (RR, 0.79 [95% CI, 0.40-1.55]) for maternal … Estimates of perinatal mortality were not statistically significant in the large US trial (RR, 1.00 [ … CI, 0.27-1.88]). 1 , 38 , 41 , 42 Estimates of preterm delivery (<37 weeks of gestation) were not statistically … 38 , 41 , 43 In the large US trial, the risk of IUGR/SGA (<10th percentile) was not statistically different
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/pnyU5fxhdBUtCdvJ3GyqzR
March 01, 2007 - significant reduction in colorectal
cancer incidence (32). … These studies reported widely
varying statistically significant reductions in the RR for
colorectal cancer … significant protective effect (RR, 0.68 [CI, 0.54 to 0.87]). … not re-
ported) was also associated with a statistically significant
risk reduction in adenomas (40) … In the setting of secondary prevention, aspirin was
associated with a statistically significant 16% reduction
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/v7kgKfbWsEFnPY3wkvkRGc
May 26, 2020 - There was a small, statistically signifi-
cant improvement in cannabis use specifically. … significant (pooled standard mean difference,
–0.08 [95% CI, –0.16 to 0.0001]; 24 trials; n = 12 801 … significant increases
in illicit drug use for at least 1 drug use outcome in the intervention
group … Three of these trials reported statistically signifi-
cant improvements in family functioning (0.3 to … • There was minimal reporting on health, social, or legal outcomes and
significant heterogeneity in
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/g2bEcQW6ae_NTFZ9KUxT_t
August 24, 2021 - Neither trial
found statistically significant differences in cardiovascular events,
quality of life … in quality of life scores that are not likely clinically significant. … Another trial
(n = 150)41 found no statistically significant difference in myocardial
infarction over … The analysis reported a statistically significant effect
modification by BMI, with greater effect on … significant.42 Both trials reported no significant dif-
ference in blood pressure among persons receiving
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/ovarian-cancer-screening
February 13, 2018 - In the 2 large screening trials (PLCO and UKCTOCS, n = 271,103), there was not a statistically significant … This difference was not statistically significant (hazard ratio, 0.89 [95% CI, 0.74-1.08]) 31 ( Table … A statistically significant difference in survival between women with index cancers in the intervention … The overall differences by group and stage were also statistically significant when comparing localized … Psychological harms were reported in a subset of 1 trial
No statistically significant differences
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ofaMtvNZ-5KdhWAJjXfZpN
February 01, 2011 - The differ-
ences in these scores, although statistically significant,
were small, and it is unclear … These stud-
ies showed mixed results: Two studies found a statistically
significant association between … Six of 11 case–control stud-
ies did not find a statistically significant association be-
tween ever … Of the 4 studies that
found a statistically significant association between indoor
tanning exposure and … significant difference, OR not
reported
Age >14 y
Not statistically significant, OR not reported
NR
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/perinatal-depression-interventions-to-prevent
April 22, 2025 - (based on symptoms, history of depression, or social or socioeconomic risk factors) demonstrated a statistically … significant larger positive effect compared with trials enrolling lower-risk, unselected populations … significant findings. 2
Physical activity interventions to prevent perinatal depression were studied … Pooled results from three trials (n=364) found a statistically significant difference in the SMD in depression … significant differences between treatment groups.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/bF5BNLvASN5r9EnP3VTJPN
December 01, 2010 - Re-
ductions in blood pressure were still statistically significant,
although slightly attenuated, at … Four other trials reported follow-up beyond 12
months, but none showed a statistically significant re … Two trials showed statistically
significant group differences in
adiposity, blood pressure, or
lipid … No statistically
significant changes were seen
for HDL cholesterol or
triglycerides.
3. … meta-analysis) showed
statistically significant
improvements in self-reported
activity levels.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/abdominal-aortic-aneurysm-screening-2014
June 23, 2014 - significant. 30 , 31
All-Cause Mortality
None of the individual trials showed a statistically significant … Sensitivity analysis using ORs and a fixed-effects model found a statistically significant result at … AAA Rupture
Invitation to screening was associated with a statistically significant reduced rate of … The Chichester trial found no statistically significant reduction in rupture rate at 15 years, although … The Western Australia trial found no statistically significant difference at a median followup of 3.6
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/folic-acid-for-the-prevention-of-neural-tube-defects-preventive-medication
August 01, 2023 - The study reported a statistically significant reduction in neural tube defects in women taking folic … The study reported no statistically significant differences associated with folic acid supplementation … This study reported no statistically significant associations between daily or less than daily folic … Two studies reported statistically significant reductions of autism associated with folic acid supplementation … Neither reported harms; however, 1 study reported a statistically significant reduction of ASD associated
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - Most trials with age subanalyses did not find a statistically significant difference in the relative … significant increase in CRC mortality at 10 years. … significant lower risk of CRC mortality at 18.3 years of follow-up (Peto OR, 0.62 [95% CI, 0.41-0.94 … ]), and the WHS reported lower CRC mortality at 17.5 years of follow-up that was not statistically significant … Low-dose aspirin use was not associated with a statistically significant increase in risk of fatal hemorrhagic