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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/oral-health-children-adolescents-screening-preventive-interventions
November 07, 2023 - All significance testing was 2-tailed; P values of .05 or less were considered statistically significant … There were no statistically significant interactions between control type, follow-up duration, or age … fraction, 0.43 [95% CI, 0.29-0.57]; I 2 = 90%; 6 trials; n = 1673).The systematic review found no statistically … significant interactions between baseline caries level, exposure to fluoride, application method, application … There were no statistically significant interactions between baseline caries severity, background fluoride
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-prevention-counseling-1996
January 01, 1996 - management 41 , 42 decreased coronary heart disease morbidity and mortality, although results were statistically … significant in only one trial. 41
A number of clinical trials have demonstrated the effectiveness … Two meta-analyses of controlled trials of nicotine replacement therapies found a significant benefit … follow-ups of 3-12 months have reported improved abstinence rates of 8-21%. 81-85 Only one result was statistically … with the help of quitting manuals. 113 Moreover, even a modest decrease in smoking rates can have significant
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/zmvjborz6pkcGVzgcP5nCw
September 30, 2024 - Trials reporting on at least 2 con-
secutive rounds of screening have generally found no statistically … diagnosed with a stage IIB or higher cancer and cancer with less
favorable characteristics was not statistically … The trials found no statistically significant difference in
detection at the second screening round ( … There were no
statistically significant differences in tumor diameter, histologic
grade, and node status … in overdi-
agnosed cases for Black women.12,13
DBT vs Digital Mammography
Three RCTs did not show statistically
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Dofv_5wDUQYVkoSDbX6Zse
May 25, 2021 - Maternal Health Outcomes
Gestational weight gain interventions were associated with statis-
tically significant … preeclampsia, postpartum hemorrhage, perineal trauma, or mater-
nal death.1,31 Stratified analyses showed statistically … significant in-
teractions between the mixed BMI category and perineal trauma,
active interventions … Stratified analyses
showed statistically significant interactions between intervention
intensity and … There
was no significant interaction between BMI category and effects on
likelihood of excess weight
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/unhealthy-alcohol-use-adolescents-adults-behavioral-counseling-interventions
August 05, 2025 - use (e.g. heart disease, cancer and liver disease). 1 , 2 However, alcohol-related injuries are a significant … AUD. 1 Alcohol Use Disorder refers to “a maladaptive pattern of alcohol use leading to clinically significant … to school or work while intoxicated, getting into fights), pooled group differences were small and statistically … significant when limited to young adults (standardized mean difference [SMD], -0.07 [95% CI, -0.13 to
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary20/suicide-risk-in-adolescents-adults-and-older-adults-screening
April 15, 2013 - A subset of these trials ( κ = 12) also reported on adverse events or a (statistically nonsignificant … significant). … significant result. … Several trials for key questions 4 and 5 reported statistically nonsignificant increases in suicide attempts … XXX No significant group differences reported.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/obesity-in-children-and-adolescents-screening-2010
January 15, 2010 - Low-intensity interventions, defined as ≤25 contact hours over a 6-month period, did not result in significant … Lower-intensity interventions that are possibly feasible for primary care did not demonstrate a significant … orlistat plus behavioral intervention compared with behavioral intervention alone resulted in a small but statistically … significant between-group BMI difference (0.85 kg/m 2 ). … Two very small studies showed no significant differences between groups. 15 There are no long-term data
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/folic-acid-prevent-neural-tube-defects-preventive-medication-1996
January 01, 1996 - In a series of 208 patients aged 2-18 years with meningomyeloceles, there were no statistically significant … Infection has not been identified as a significant problem in any large studies. … studies reported a protective effect of greater dietary folate intake, although not all results were statistically … significant or adequately reported. … on plasma zinc concentrations after 2 and 4 months, however. 91 One cross-sectional study found a significant
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/osteoporosis-screening-june-2018
June 26, 2018 - with parathyroid hormone in men was consistent in the direction of benefit but the finding was not statistically … significant. 16
Potential Harms of Screening
The USPSTF found no studies that directly examined … There was also no significant difference for incidence of all clinical fractures (15.3% vs 16.0%; HR, … However, the study reported a statistically significant reduction in hip fracture incidence (2.6% vs … This study (n = 7868) evaluated treatment with denosumab in women and found a significant reduction in
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/tdMpbcxNJQ-7Tr-KV8jF3f
January 01, 2010 - n=8)
as opposed to large (n=3) improvements in self-
reported dietary behaviors, most of which were
statistically … significant. … small (n=3),14,15,21,22 medium (n=6),8,21,22,24,30,35
and large (n=4),8,23,28,31 most of which were statistically … significant. … More than one-half of these studies found
that self-reported dietary changes were accompanied
by significant
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication
August 23, 2022 - Only 1 trial, WOSCOPS (West of Scotland Coronary Prevention Study; n = 6595), reported a statistically … significant difference between statin and placebo in risk of cardiovascular mortality (RR, 0.68 at 6 … was associated with a slight reduction in cardiovascular mortality risk at 2 to 6 years that was not statistically … significant (RR, 0.91 [95% CI, 0.81 to 1.02]; ARD, −0.13%; [95% CI, −0.25% to −0.02%]). 13 , 31
Evidence … significant. 34 , 35 However, ALLHAT-LLT had several limitations, including its open-label design,
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/B73a4kJhxeaYyXK6gozbbY
May 24, 2022 - Four trials (n = 4819) found no significant
differences between screening vs no screening in visual acuity … However, direct evidence found no
significant association between vision screening vs no screening in … sufficiently pow-
ered to assess rates of cardiovascular events or other serious
adverse events, although no statistically … significant differences
were reported.24,27,44,66
Newer vs Older VEGF Inhibitors for Wet AMD
Three … However, di-
rect evidence found no significant association between vision screen-
ing vs no screening
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/pxMbTT69NULYZRaZ9xs7Du
May 01, 2004 - Suicidal ideation with a
specific plan of action is associated with a
significant risk for attempted … With respect to the outcomes on suicide
attempts and completion, no statistically significant
effects
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/za7BqXMwT8BMz4Z_ygrvKm
May 01, 2004 - screened group were in Stage I, compared with only
5% in the control group.3,10 This difference was not
statistically … significant. … There is a significant potential for harms
associated with screening for ovarian cancer,
although there
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/hepatitis-b-virus-infection-screening-nonpregnant-adolescents-adults-may-2014
June 18, 2014 - Pooled estimates showed that antiviral therapy was statistically significantly more effective than placebo … evaluated achieving virologic remission with lamivudine therapy in HBeAg-negative patients and found no significant … Harms of Screening and Treatment
Pooled estimates showed no statistically significant difference between … There were no statistically significant differences between entecavir and lamivudine or tenofovir and
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/lipid-disorders-in-children-screening-july-2016
August 09, 2016 - The studies reported statistically significant reductions in LDL-C levels from baseline, with most effect … The intervention resulted in statistically significant reductions in mean LDL-C and TC in the intervention … difference was greatest in year 1 (TC, -6.1 mg/dL; LDL-C, -4.8 mg/dL; P<0.001) and smaller but still statistically … significant in year 3 (TC, -3.3 mg/dL [P=0.04]; LDL-C, -3.3 mg/dL [P=0.02]).
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/vv5kXtX5QDg2948gog66pd
December 07, 2021 - All significance testing was 2-tailed;
P values of .05 or less were considered statistically significant … Topical fluoride was associated with significant decreased car-
ies increment (13 trials, n = 5733; mean … there were no statistically significant interactions on these factors
and caries outcomes (Table 1 and … Four new trials (n = 4141) reported no significant differences be-
tween fluoride varnish vs placebo … Although there was a significant interaction be-
tween younger age and larger reduction in likelihood
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/CXDusYW7s2xdypXMpnW9sw
June 20, 2023 - Signifi-
cance testing was 2-sided, and results were considered statistically
significant if P � .05. … Psychological
interventions showed a relatively small but statistically sig-
nificant reduction in anxiety … How-
ever, the effect was smaller and not statistically significant among
mixed populations of people … The overall pooled effect size for all 22 studies
was statistically significant, in favor of the intervention … significant reduction in anxiety symptom severity in primary
care patients with anxiety (SMD, −0.41
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-screening-for-multifactorial-dyslipidemia/lipid-disorders-in-children-screening-july-2016
August 09, 2016 - group received placebo muffins and bread. 25 Compared with placebo, flaxseed was associated with non–statistically … significant lower TC concentrations (relative change of −4% [95% CI, −10% to 2%]; P = 0.20) and LDL-C … significant decreases in LDL-C and TC relative to the control group were seen in participants randomized … experienced decreases in total cholesterol relative to the control group, but these decreases were statistically … significant only at years 1 and 3.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary2/healthy-diet-and-physical-activity-counseling-adults-with-high-risk-of-cvd-august-2014
August 26, 2014 - We found no evidence for significant publication bias except for triglyceride-level outcomes (Egger test … significant improvements in dietary intake (such as fat, saturated fat, fruit and vegetable, and total … physical activity–only counseling trials that reported behavioral outcomes at 12 to 24 months found statistically … significant improvements in self-reported physical activity (that is, minutes per week or percentage … In 2 instances, results were no longer statistically significant for short-term (less than 12 months)