-
effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_executive.pdf
March 01, 2011 - Studies rated “poor” have significant flaws
that imply biases of various types that may invalidate … as
well as slightly more ICA referrals (13% vs. 8%; RD,
5; 95% CI, -4 to 14 per 100 people; p not statistically … Through 6 months,
ICA referral was statistically less frequent in the stress
echocardiography group … For the latter study,
although the differences between groups were statistically
significant for both … comparators, they may not be
clinically significant.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
December 05, 2018 - The study reported no
statistically differences for depression, anxiety, bipolar disorder or psychotic … no differences in first-time psychiatric episodes treated at
outpatient facilities but did find a significant … The authors suggest that
childbirth could serve as a “potent and highly significant trigger” of severe … high-dimensional propensity scores have found that full
adjustment leads to many associations being no longer statistically … significant.38, 39
The heterogeneity of included populations and pharmacologic interventions adds
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
January 01, 2014 - additives to
dressings, such as shale oil, tenuiflora bark, and human
keratinocyte lysate, found no statistically … significant
difference. … One of the studies demonstrated a statistically
significant improvement in ulcer healing as measured … percent) than with
trimethoprim (33 percent) or placebo (30 percent), but the
differences were not statistically … significant.
-
effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
October 01, 2007 - The
advent of Medicare Part D for outpatient prescription drugs has
drawn significant attention to the … ie, outpatient rather than inpatient).14
Methods to Control Confounding and Reduce
Bias
Among the significant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
August 18, 2016 - neurobehavioral disorder, with a
prevalence that has increased since the 1990s.1 In the United States, there are significant … of children 4
through 17 years of age have been diagnosed with ADHD as of 2011; however, there is
significant … The significant geographic
variations in care likely reflect differences and uncertainty in care delivery … There were no other significant changes to the KQs or
proposed methods. … These studies had significant flaws that might have
invalidated the results.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - This enrollment strategy, while practical, has
the potential to introduce significant bias for numerous … this effect can provide insights into the impact of the missing
data as well as how to report and statistically
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/registries-guide_executive.pdf
April 01, 2007 - Because certain requirements may have significant
cost implications, a risk-based approach to
developing
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
September 01, 2011 - To statistically pool
studies using these two
outcomes, would require
converting all outcomes into … Further
in Table 32 (p. 137), the language about ‘small but statistically significant effects’
does … The pooled results do not show a significant benefit, nor do
individual trials. … Not a single study showed a significant benefit in pooled results, and neither did the
metaanalysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-disposition.pdf
May 26, 2017 - We chose not to search the Web of Science
database given its significant overlap with MEDLINE
and PsycInfo … They are also frequently adapted to be
targeted to specific study participants given the
significant … compare the two active groups and, following some threshold
criterion, then lump them if there was no significant … TEP Reviewer
#5
Results I find it shocking that the authors do not view as significant the
observation … However, it seems to
me, given the lack of clear evidence that medical treatments have
any significant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-future_research.pdf
February 01, 2013 - The review found that few studies of combined PT modalities demonstrated no
statistically significant … Investigators will need to collect
data on known confounders and statistically adjust
in analysis. … The review found that few studies of combined PT modalities demonstrated no
statistically significant … valid with a large sample size and the collection of many potentially
confounding variables used to statistically … Importance:
Represents a significant disease burden, large proportion, or priority population.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-pharmacologic-treatment_research-protocol.pdf
December 27, 2016 - patients with severe
COPD (FEV1 <50% predicted normal) and a history of repeated
exacerbations, who have significant … patients with
severe COPD (FEV1 <50% predicted normal) and a history of
repeated exacerbations, who have significant
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
January 30, 2012 - Although generally not as immediately life-threatening as ventricular arrhythmias, AF is
associated with significant … to result in death.8-10 Consistent with the nature
of these events, AF-related stroke constitutes a significant … have a history of bleeding, are
pregnant, and/or are not compliant with treatment (which can be a significant … There were no other significant changes to our KQs or proposed methods. … These studies had significant flaws that might have invalidated
the results.
-
effectivehealthcare.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
December 01, 2013 - Key Expert Comments: Overall, experts stated there remains a significant unmet need for
earlier … Although a significant capital investment may be
required to retrofit frequently touched surfaces in … All but one item sampled had a
statistically significant reduction in microbial burden.
86
Clinical … There remains a significant unmet need to reduce these infections
because current infection control … Although a significant capital
investment is required to retrofit frequently touched surfaces, the
-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - thromboembolism when anticoagulants are
contraindicated or inadequate for management of venous
thrombosis with significant … Poor (high risk of bias) These studies have significant flaws that imply biases of
various types that … A p-
value of <0.05 will be considered statistically significant for all analyses.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - thromboembolism when anticoagulants are
contraindicated or inadequate for management of venous
thrombosis with significant … Poor (high risk of bias) These studies have significant flaws that imply biases of
various types that … A p-
value of <0.05 will be considered statistically significant for all analyses.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
July 01, 2012 - It does require
significant training and more attention than its invasive ventilation
counterpart which … of NPPV in weaning and post-
extubation respiratory failure studies were conducted in centers with
significant … to judge in practice, since (1) statistical testing is meaningless for
‘Table 1’ differences as any significant … The difference between
NPPV and standard care is significant when comparing the criteria for
intubation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
December 31, 2017 - trauma
• Failure to recall an important
aspect of trauma
• Loss of interest or participation in
significant … disturbance
• Duration of disturbance symptoms is more
than 1 month
None
Criterion F: Clinically significant … or impairment
• Duration of disturbance symptoms
is more than 1 month
Criterion G: Clinically significant … PTSD
The public health importance of this investigation is paramount because PTSD is associated with
significant … A “poor” study has significant bias (e.g., stemming from serious errors in design or
analysis) that
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_disposition-comments.pdf
May 27, 2014 - That is, you calculated
NNT only when the results for an intervention-outcome category
was statistically … significant. … say this sensitivity analysis of adding
another study showed ‘attenuated effect that is no longer
statistically … significant’ rather than saying you found ‘no
difference’. … There was also significant heterogeneity.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
September 01, 2012 - and mortality associated
with preterm birth represent untold
distress for families, as well as significant … The five studies using
suppositories observed a statistically significant
prolongation of gestation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
December 01, 2017 - results below by category of
intervention, providing data about adverse events when
available and statistically … Studies consistently reported
significant improvement in measures of quality of life
symptoms (days … Four studies reporting the outcome consistently
noted significant improvements in quality of life measures … Endometrial Ablation
One fair quality study addressed endometrial ablation
and reported significant … None were statistically powered
to examine effect modification by characteristics to
answer questions