-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
November 01, 2020 - Their
guidance also recommends not reporting summary statements for systematic review results as
statistically … significant or nonsignificant—a change from typical convention. … significant or not significant based on
confidence intervals or P values. … significant but not clinically
important.3
Strength of evidence Direction
of effect
Statistical … significant.3
Strength of evidence
Direction of effect
Statistical significance
Social function
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - Color is used for visual emphasis only.
9
Effect size: None (i.e., no effect/no statistically … significant effect), small, moderate, or large increased benefit; SOE:
[] = low, [] = moderate, … significant. … Effect size: None (i.e., no effect/no statistically significant effect), small, moderate, or large increased … significant.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/glucocorticoid-injections_clinician.pdf
June 01, 2016 - or 6 weeks.
»» Interlaminar injections of glucocorti-
coids plus lidocaine were associated
with statistically … significant advantages
over interlaminar injections of lidocaine
alone with respect to function and … treatment groups
but greater functional improvement with glucocorticoids plus
lidocaine, which was statistically … but not clinically significant
(1.2-point difference in RMDQ score between groups).
»» The small benefit
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_disposition-comments.pdf
March 10, 2010 - Nor is it clear if the differences
between treatment and placebo were statistically significant. … We considered estimates precise if they provided
statistically significant differences between drugs … In this CER, we do not have comparisons where the results are
statistically significant, but the confidence … The Breast Cancer Prevention Trial (BCPT) showed a
statistically significant decrease in non-invasive … The meta-analysis did not show a statistically significant decrease in
noninvasive cancers, but the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
September 01, 2014 - significant
difference
ERUS No statistically
significant difference
aOR < 1 indicates a lower risk … The MRI versus
PET/CT comparison (single study) was not statistically
significant (0.467; confidence … significant
difference
No statistically significant
difference
MRI favored for avoiding
overstaging … There were no statistically
significant differences in accuracy between MRI and
CT for rectal T staging … There were no statistically
significant differences across the modalities, but there was
a nonsignificant
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - (12% THC, Smoked) No evidence Insufficient (1) No evidence
a Effect size: none (i.e., no effect/no statistically … significant effect), small, moderate, or large increased risk; SOE: + = low, ++ = moderate, +++ = high … .
b Findings with small or larger magnitude of effect, not statistically significant; but with SOE rating … significant effect), small, moderate, or large increased risk; SOE: + = low, ++ = moderate, +++ = high … .
b Findings with small or larger magnitude of effect, not statistically significant; but with SOE rating
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
September 01, 2011 - This study
investigated women from the Matria database and
reported a statistically significant difference … Cohort studies of women with RPTL and
single or twin gestation demonstrated statistically
significant … All studies that reported low birth weight
found statistically significant differences in favor of SQ … Pregnancy
prolongation index was reported in two cohort
studies.13,20 Both found statistically significant … Incidence of NICU Admission:
Statistically significant differences in favor of the SQ
terbutaline pump
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
September 21, 2012 - Without the context of a numeric
rationale for the study size, readers may misinterpret
the lack of a statistically … significant difference in
effect as false reassurance of lack of harm, or falsely
conclude that there … In the case of a trial comparing
treatments, this is the probability of finding a
statistically significant … i.e., false
positive or false negative) rank higher as possible
explanations for a finding of “no statistically … significant difference” because randomization has
overcome the potential confounding, the protocol
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
April 18, 2013 - We did not detect statistically significant
differences in outcomes among botulinum
formulations. … We did not detect statistically significant
differences in outcomes among botulinum
formulations. … Post hoc subgroup analysis reported
statistically significant reduction in migraine
attacks only in … The pilot study by Winner et al (2005) did not
show a statistically significant difference in the 50% … We added an
explanation of statistically significant
differences when 95% CI of attributable events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
July 01, 2016 - (Insufficient evidence)
*Statistically significant differences between treatment and placebo groups. … None reported statistically significant
clinical differences between treatment and control groups … (Insufficient evidence)
*Statistically significant differences between treatment and control groups. … (Insufficient evidence)
* Statistically significant differences between treatment and control groups … (Insufficient evidence)
* Statistically significant differences between treatment and control groups
-
effectivehealthcare.ahrq.gov/sites/default/files/cer30_hip-fracture-pain-executive-summary_20110517.pdf
May 01, 2011 - One RCT (n = 30)
reported a statistically significant difference of
additional pain relief in favor … Two
RCTs reported 30day mortality (n = 99) and found no
statistically significant difference in mortality … Similarly, in one cohort study (n = 291) there was a
statistically significant difference in favor of … There were no significant differences
between groups. … There was no significant difference
between groups.
KQ 3: Adverse effects.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
April 01, 2020 - • No statistically significant differences between an opioid plus nonopioid vs. … Effects on risk of discontinuation due to adverse events were not
statistically significant (6 trials … significant,
but there was an interaction with trial quality and effects were statistically
significant … Effects on opioid dose were not
statistically significant (SOE: low).
3j. … Some differences were statistically
significant but below the pre-defined threshold
for small (<0.5
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
September 01, 2009 - The STAR
head-to-head trial indicated no statistically
significant differences between raloxifene and … No Results are not statistically significantly different. … hysterectomies (RR 0.44; 0.35, 0.56) than
tamoxifen, but differences for endometrial cancer
were not statistically … significant (RR 0.62; 0.35,
1.08) … No Results are not statistically significantly different.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
September 01, 2013 - Only two of the effects assessed were statistically
significant, each in a single study: a multiplicative … The statistically significant findings should not
be overinterpreted, given the number of comparisons … Statistically significant
interaction effects were reported only in the study that
assessed whether … After 6
months of followup, there was no statistically significant
difference between the randomized … The two larger studies (the GRAVITAS and the
TRIGGER-PCI trials) found no statistically significant
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-disposition-comments.pdf
October 01, 2021 - Those citations do not mention well-designed
published studies indicating statistically significant … symptoms” twice on page 19, there is no discussion of
well-designed, published studies that reported
statistically … significant increases in these symptoms or
any mention of the term Breast Implant Illness. … FDA held a 2-day meeting focused primarily
on breast implant illness, and researchers have reported
statistically … significant increases in these symptoms and
related diseases [for example, see 3,4].
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
March 01, 2013 - (INSUFFICIENT)
Compared with placebo in one study,
leflunomide produced statistically significant, … significant, but not clinically significant,
improvement in functional capacity. … (INSUFFICIENT)
Compared
with
placebo
in
one
study,
leflunomide
produced
statistically … significant,
but
not
clinically
significant,
improvement
in
disease
activity …
significant,
but
not
clinically
significant,
improvement
in
functional
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_executive.pdf
January 27, 2012 - Similarly, our meta-analysis found no statistically significant difference between disulfiram
250 mg … of four head-to-head RCTs49-52 similarly
found no statistically significant difference between the … significant. … significant. … Our meta-analyses of head-to-head trials found
no statistically significant difference between the two
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
March 01, 2024 - • Head-to-head comparisons did not detect statistically significant differences
between stimulant … Head-to-head comparisons did not detect statistically significant
differences between stimulants and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
June 01, 2012 - whether a given change in a certain scale score
is clinically meaningful, even when the change may be
statistically … significant. … significant increase in the CIQ
score from pretreatment to post-treatment, without a
significant improvement … However, group differences were not statistically
significant. … Heterogeneity is
controlled for statistically.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-immunodeficiency-virus-rapid-response.pdf
May 01, 2025 - • All three studies found statistically significant increase in CD4 count from baseline after
NSPT … • Weak evidence from all three single-arm studies found statistically significant increase in
CD4 … All three studies reported
statistically significant increased CD4 count from baseline. … Nobre et al. reported a statistically
significant trend of improved CD4 count from baseline to 90 days … Despite the statistically and clinically significant improvement in CD4 count among patients
who received