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Total Results: 1,182 records

Showing results for "statistically significant".

461. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity_hi_impact.pdf
     April 17, 2012 - But the surgery has significant associated risks and mortality; and the drug therapy has undesired … The committee stated “the lack of obesity medications is a significant unmet medical need.” … discontinuation rate, which they believe to be significant adverse factors. … phase 3 trials show obese and overweight patients taking Arena Pharmaceuticals' Lorcaserin achieved statistically … significant weight loss.

462. Disposition of Comments Report for Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
     July 08, 2014 - Neither showed statistically significant differences between groups, although the study size makes … identifying significant differences difficult. … pregnant women who did not receive an SSRI (depression status unknown) found the risk for ASD was statistically … CI 1.50 to 7.47), while the risk in women taking an SSRI for another indication was lower and not statistically … significant (OR 1.61; 95% CI 0.85 to 3.06).”

463. Peripheral-Artery-Disease-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
     January 31, 2013 - in which aspirin was used for primary prevention in patients with vascular disease did not find a statistically … significant benefit.19 The CAPRIE (clopidogrel versus aspirin in patients at risk of ischaemic events … First, there were significant intertrial variations in the control groups, the types and duration of … most recent Cochrane review, performed in 2008, compared exercise training to usual care.22 It found statistically … What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug

464. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - A maladaptive pattern of alcohol-use leading to clinically significant impairment or distress, as manifested … Alcohol dependence11 A maladaptive pattern of alcohol use, leading to clinically significant impairment … Such a review will provide significant assistance to dissemination efforts to educate U.S. clinicians … The potential to improve the health and welfare of the U.S. population could be significant as well. … A study assessed as high risk of bias has significant risk of bias (e.g., stemming from serious issues

465. Fibromyalgia Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
     January 01, 2015 - All treatment-by- MDD interactions for pain were either not significant or not reported. … The interaction result was not reported; the text implies that it was not significant.3 Treatment-by-MDD … Impression of Improvement (PGI-I).76 For the PGI-I outcome, the duloxetine-by-MDD interaction was not statistically … The interaction term was not significant. … (p >0.1),20 but the treatment-by- MDD stratum interaction was significant for “treatment- emergent”

466. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - 2008 Institute of Medicine (IOM) report on the treatment of PTSD, the condition “…develops in a significant … trauma • Failure to recall an important aspect of trauma • Loss of interest or participation in significant … of disturbance • Duration of disturbance symptoms is more than 1 month Criterion F: Clinically significant … distress or impairment • Disturbance causes clinically significant distress or impairment in social … A “poor” study has significant bias (e.g., stemming from serious errors in design or analysis) that

467. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
     April 01, 2013 - Potential for significant health impact • Potential for significant health impact: − To improve … − To reduce significant variation related to quality of care. … • Potential for significant economic impact, reducing unnecessary or excessive costs. … Lack of a definition of “clinically significant improvement” in diagnostic accuracy. 3. … Lack of a definition of “clinically significant improvement” in diagnostic accuracy. 3.

468. Disposition of Comments for Psychological Treatments and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_disposition-comments.pdf
     April 03, 2013 - pooled effect size with a 95% confidence interval contained completely between -.28 and +.28 (often non statistically … significant We disagree. … That would be true even if such a pooled effect size were statistically significant (e.g., the confidence … indicating the thresholds on your “tree” plots would then distinguish between two treatments that are statistically … It's short half-life can create difficulties with patient adherence and it also has significant issues

469. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
     May 13, 2014 - To determine whether this potential population heterogeneity would have a significant impact on our … The one possible exception, that might be considered a significant change in the effect size, was for … that our meta-analyses for variation in naltrexone response related to OPRM1 polymorphisms found no statistically … We realize that this outcome in this study was statistically significant. … As presently offered, this report is not likely to generate significant interest.

470. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - Preliminary data suggest that in some patients, low- dose ketamine produces significant, rapid (within … Experts thought that SPARX could positively improve patient health outcomes without placing significant … Some experts concluded that this cost would not be a significant burden to patients with reduced financial … adolescents who completed SPARX had larger mean CDRS score reductions (10.32 vs. 7.59, p=0.079) and statistically … Patients who finished this tailored intervention demonstrated statistically significant, sustained

471. Mrsa-Screening-2010 Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
     January 01, 2010 - Pittet and colleagues demonstrated a significant reduction in MRSA bloodstream infections in one especially … Jernigan and colleagues noted a significant decrease in the risk of MRSA transmission when isolation … Only the addition of active surveillance resulted in a statistically significant decline in the incidence

472. Disposition of Comments Report for CER 226: Labor Dystocia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-226-labor-dystocia-comments.pdf
     May 14, 2020 - In general, the manuscript is well-written, with very few significant grammar or syntax corrections … General Peer Reviewer #2 Page 27 Line 48…Why are some statistically significant (and for that matter … I consider this a significant limitation. … If just describing statistically-defined confidence intervals, this would be almost impossible to define … This is mainly driven by the significant limitation of the data available. Thank you.

473. Disposition of Comments Report for Recurrent Nephrolithiasis in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
     July 26, 2012 - There is clearly a significant need for more Level One investigations in this field. … CI, 0.39 to 2.80]) to clarify that the difference in risk of symptomatic stone recurrence was not statistically … significant. … There is clearly a significant need for more Level One investigations in this field. … By counting only symptomatic episodes as “recurrences”, a significant number of episodes of true stone

474. Disposition of Comments for CER 153 Non-Muscle-Invasive Bladder Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_disposition-comments.pdf
     October 27, 2015 - The latter is an area of significant clinical need and confusion with regard to best treatment. … There are significant limitations to any analysis that can be performed especially with markers. … This is considered an area of significant need but is not addressed. … SWOG 8507 clearly shows a highly statistically significant benefit to 3 yr. maintenance vs. induction … FISH, but the table shows a significant difference in specificity between the two (p=0.0001).

475. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
     June 22, 2017 - The authors correctly point out that post-phlebitic syndrome can be a significant clinical problem … Venogram only DVT did not rank as significant Symptomatic DVT was an outcome of interest included … Using statistical techniques we did not find significant evidence of bias (significant differences … Peer Reviewer #4 Results Results for network MA For the many significant comparisons, do the FE … model provide a role to make is easier to see significant comparisons?

476. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
     March 29, 2011 - number of adolescents and young adults currently affected by an ASD, as well as a significant cohort … ASDs are characterized by significant impairments in social interaction, behavior, and communication … While we acknowledge that ASD undoubtedly has significant effects on family functioning, exploring the … They are also frequently adapted to be targeted to specific study participants given the significant … In contrast to Autistic Disorder, there are no clinically significant delays or deviance in language

477. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/09_infectiousdisease_potential_high_impact_june_2012.pdf
     January 01, 2012 - In the post-treatment period, significant reductions in depression and HIV RNA were observed, while … significant increases in CD4 T-cell count and antidepressant prescriptions were observed compared …  Key Expert Comments: Overall, experts stated a significant unmet need exists for earlier anal … Experts thought that emtricitabine/tenofovir could have a significant impact on health promotion by … All but one item sampled had a statistically significant reduction in microbial burden. 107 Clinical

478. Disposition of Comments for CER 167 Renal Masses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
     February 24, 2016 - Executive Summary Key Question 3b, Page 23/Perioperative Outcomes Page 140 I have a significant issue … Therefore, the clinically significant implications of nephron- sparing management strategies are not … We changed the language to state: “but is associated with a significant non-diagnostic rate.” … Any specific instances of individual studies that diverged from this finding (and perhaps state a statistically … significant association, regardless of the magnitude of difference) are discussed in the main text

479. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
     November 27, 2012 - cirrhosis, liver cancer and liver failure often take decades to present, it is anticipated that a significant … Summary (ES-12) Row 1: "…slightly better short-term scores…" Please state whether the difference is statistically … significant, and, if so, please state the magnitude of the difference and the p-value. … We revised this to indicate that differences were statistically significant. … factors for infection and emphasize the importance of parenteral drug abuse and the high prevalence of significant

480. Breast-Abnormalities-Tests-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_executive.pdf
     February 01, 2012 - early-stage cancers who mistakenly get triaged into “return to normal screening” may experience a significant … Health Care Program 2 further assessment after a screening mammography do not have cancer, and significant … prevalence of disease in the study population and whether or not the image readers were blinded was statistically … that whether the studies blinded the image readers and accounted for inter- reader differences were statistically … Angle between 1 and 4 min gives the most significant difference in time-intensity curves between benign