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Total Results: 1,181 records

Showing results for "statistically significant".

421. Methods Future Research Needs Number 8: Framework for Considering Study Designs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
     March 01, 2012 - Negotiations with the holders of the secondary data may take significant time. … Unlikely to have significant constraints on sample size. … Negotiations with the holders of the secondary data may take significant time. … Negotiations with the holders of the secondary data may take significant time. … characteristics, or, commonly, differences in co-interventions which may be difficult to adjust for statistically

422. Abnormal-Uterine-Bleeding Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
     March 01, 2013 - Effects were statistically comparable, but the trial was not powered to show equivalence or noninferiority … Both were statistically comparable in this small trial. … a dose of 1.95 to 4.5 grams per day for 4 to 5 days from the onset of bleeding led to a clinically significant … In head-to-head comparisons with statistically significant differences, the LNG-IUS has one trial showing … disease, thyroid disease, abnormal cervical cytology, noncyclic bleeding, history or presence of significant

423. GRADING THE STRENGTH OF A BODY OF EVIDENCE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
     November 01, 2013 - For example, significant differences favoring an intervention for efficacy outcomes or nonsignificant … of outcomes data from small studies 15 when those findings, if reported, would be either not statistically … consistently find that an intervention improves an outcome (e.g., apnea-hypopnea index is reduced by a statistically … This should not be misunderstood to mean that all statistically nonsignificant effects should lead to … when the number of available trials is large, then the test becomes overly sensitive.1 Furthermore, a statistically

424. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - The Juvenile Diabetes Foundation has committed significant resources to developing a system, and systems …  Key Expert Comments: Overall, experts commented that a CLS has significant potential to simplify … Additionally, experts indicated that these systems would likely need significant upkeep by users and … While experts thought that the initial use of these systems would be limited, they saw significant … Authors reported, “Trial A and B data combined demonstrated a statistically significant effect at week

425. Disposition of Comments Report for Strategies To Reduce Cesarean Birth in Low-Risk Women (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_disposition-comments.pdf
     January 01, 2010 - The most recent Cochrane review of continuous labor support found a significant reduction in cesarean … We do define "same" as not statistically different across the intervention and comparison arms in each … concur that it is harder to dismiss the potential for benefit of a strategy that did not provide statistically … There were no statistically meaningful assessments of risk of harms from these techniques in the included … It is a short step from "no statistically significant difference" to "this intervention is safe."

426. Disposition of Comments Report for Intravascular Diagnostic Procedures and Imaging Techniques Versus Angiography Alone in Coronary Artery Stenting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_disposition-comments.pdf
     February 26, 2013 - Peer Reviewer 6 Results page 20 line 5: “Significantly” should read significant Edited. … Our review addresses the question of stenting a functionally significant stenosis for the comparison … These tools offer significant benefits which should be elucidated with respect to their ability to … The DEFER study demonstrates the significant positive impact of utilizing FFR in assessing lesions and … At two years, there was also a significant benefit in terms of anginal class in favor of the Defer

427. Reduction in Medication Use after Bariatric Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bariatric-surgery_research.pdf
     June 01, 2010 - Many of the differences were statistically significant in this large cohort, although the clinical … In our model, the ICD-9-based ―obesity EDC‖ had a very significant and sizable predictive coefficient

428. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-knee-update-disposition-archived.pdf
     May 04, 2017 - We repeated the calculations of effect sizes and did not find significant differences. … significant difference in baseline values. … from the pooled analysis, we did note that it was an outlier and was responsible for the lack of a statistically … significant improvement in WOMAC pain and function with strength training. … difference in varus moment during stance, and Nadaud et al. demonstrated significant medial condylar

429. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-disposition.pdf
     May 04, 2017 - We repeated the calculations of effect sizes and did not find significant differences. … significant difference in baseline values. … from the pooled analysis, we did note that it was an outlier and was responsible for the lack of a statistically … significant improvement in WOMAC pain and function with strength training. … difference in varus moment during stance, and Nadaud et al. demonstrated significant medial condylar

430. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - Nonbiologic systemic therapies may be effective but can be associated with significant short-term and … The other statistically significant difference in DLQI was in patients who had PASI 50 to 75 compared … Together, these factors precluded the ability to statistically pool data. … therefore, we could not determine whether the difference in change between the treatment groups was significant

431. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - and Objectives for the Systematic Review Depression is a complex mental illness that can result in significant … The results suggest a modest and statistically significant advantage for remission rates when switching … We will evaluate the extent of statistical heterogeneity using a Chi-square (statistically significant

432. Future Research Needs for Treatment of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
     February 01, 2012 - significant. … study would be whether the interaction term (between the main effect and the predictor variable) is statistically … significant. … of interest in such a RCT would be whether the compliance with CPAP, MAD, or other treatments is statistically … Potential for significant health impact: - To improve health outcomes - To reduce significant variation

433. Total Worker Health® (TWH) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/worker-health_executive.pdf
     April 01, 2016 - A study assessed as high risk of bias has significant risk of bias (e.g., stemming from serious errors … chronic diseases, they concluded that little or no evidence shows that integration itself confers a significant … about the positive effects of TWH interventions or summarized benefits using primarily numbers of statistically … significant outcomes across studies; they generally did not consider study limitations, directness … Furthermore, among studies eligible for KQ 2, many had methodological drawbacks that introduced significant

434. Evidence Report No. 222, Data Linkage Strategies To Advance Youth Suicide Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research.pdf
     October 01, 2016 - Mental Health (NIMH)-funded Clinical Trials], the widespread data sharing by research communities adds significant … Researchers typically look for a significant interaction term followed by probes to determine whether

435. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1312.pdf
     October 01, 2014 - did not demonstrate superiority of mifepristone over placebo.11 However, phase III data revealed a statistically … significant linear association between mifepristone plasma concentration and clinical response. … their plasma that was greater than the 1660 nanogram per milliliter threshold mentioned above, statistically … Therefore, the expected change in upfront costs might be less significant than these experts believe … This statistically significant superiority was maintained 7 days after administration.88 Several

436. Evidence Summary: Comparative Effectiveness Review No. 238: Cervical Ripening (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-evidence-summary.pdf
     March 01, 2021 - Evidence Summary: Comparative Effectiveness Review No. 238: Cervical Ripening Comparative Effectiveness Review Number 238 Cervical Ripening in the Outpatient Setting Evidence Summary Main Points • The highest strength of evidence for outcomes of outpatient cervical ripening found in this report was low, with …

437. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1412.pdf
     January 01, 2015 - The JDRF (formerly the Juvenile Diabetes Research Foundation) has committed significant resources to … Significant HbA1c reductions observed over the 39 weeks of the study ranged from a “mean of 1.4% to … Two dosages were used and both (40 mcg/day and 60 mcg/day mini-pumps) reportedly showed statistically … significant results versus control group and were well tolerated. … Patients who had HbA1c levels “above 8.5%” had statistically significant “mean reductions up to 2.1%

438. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/alcohol-pharma-final-protocol.pdf
     January 01, 2023 - Definition Alcohol-use disorder (DSM-5)5 A maladaptive pattern of alcohol use leading to clinically significant … A maladaptive pattern of alcohol use leading to clinically significant impairment or distress, as manifested … of treatment, which can be subsumed under the concept of harm reduction.31 These measures include significant … Furthermore, during the COVID-19 pandemic, researchers at RTI International found significant increases … A study assessed as high risk of bias has significant risk of bias (e.g., stemming from serious issues

439. Disposition of Comments for CER 196 The Role of Immunotherapy in the Treatment of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-196-disposition-comments-immunotherapy-asthma.pdf
     March 23, 2018 - Why is it only moderate strength when all of the cited studies show significant reduction and two have … The strength of evidence considers several domains and is not based solely on statistically significance … Response TEP #1 Results Page 28, line 34: “The second RCT found statistically … significant improvement in asthma symptoms with a decrease of 0.41 in ACQ score.”.

440. Disposition of Comments for CER 177 Agitation Aggression Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_disposition-comments.pdf
     March 21, 2016 - Additionally, in some cases, authors inappropriately conclude differences exist when the differences are not statistically … significant. … , "Without an understanding of what constitutes a clinically meaningful change, interpretation of statistically … significant differences ... was challenging." … Yet in many places throughout the report, when a statistically significant result is noted, the phrase