-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - and behavioral disorders
A recent meta-analysis of 15 placebo-controlled
trials found a small but statistically … significant
benefit for risperidone and aripiprazole on
agitation and psychosis outcomes. … Olanzapine caused significant weight gain in all
studies. … The difference in risk for death was small but
statistically significant. … significant, nor
were differences between olanzapine and
conventional antipsychotics.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
April 01, 2013 - significant impact on use of acute drugs. … RCTs reporting harms were not necessarily powered to
detect statistically significant differences in … Post hoc subgroup analysis of one
RCT found statistically significant reduction in migraine
frequency … We
could not determine the clinical importance of statistically
different changes in scores. … • An intensive pharmaceutical care campaign had no
statistically significant impact on use of drugs
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - When they analyzed specific drug-drug
or drug-placebo comparisons, their results were not
statistically … significant. … Similarly, our report did not
find any statistically significant differences between
specific oral diabetes … was slightly lower in the control
group than in the rosiglitazone group, but the difference
was not statistically … significant.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow-disposition-170415.pdf
January 12, 2017 - We reported the pooled differences in AUROC
values with 95% CIs, which were statistically
significant … significant and for the pooled
result to be statistically significant; in fact,
increasing statistical … These
differences were statistically significant, in part
due to the large sample sizes evaluated in … significant
differences. … Statistically, it is quite
easy to attain statistical significance when some of
these studies have
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
March 01, 2013 - We
did not find consistent statistically significant effect modification via investigation of whether … However, we
caution that few of the differences between drugs are statistically significant, a subject … k from random effects model gives the same results, though
the drugs’ differences are not statistically … significant. … Even
though our Bayesian and frequentist odds ratios do not show many statistically significant
differences
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
September 07, 2012 - The new study by Combs added 81 triplet
pregnancies and reported a statistically
significant higher … The findings are either statistically
different or significance was not reached. … significant. … differences in gestational age with treatment but only one of
these is marked as statistically significant … The new study by Combs added 81 triplet
pregnancies and reported a statistically
significant higher
-
effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - EPC reviewers should designate an evidence base as being inconsistent when different studies show statistically … significant effect sizes in opposite directions. … significant (95% confidence interval [CI], −8 to +1). … significant (95% CI of −8 to −2). … significant (95% confidence interval [CI], −4 to +3).
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1406.pdf
June 01, 2014 - clinical
burden was considered by expert commenters to present a significant unmet medical need. … They noted the drug could offer a significant advantage over existing therapies if it was
shown to … Statistically significant
improvements in the WOMAC and Numeric Rating Scale scores were observed in … who were treated with three intra-articular PRP injections every 2
weeks, 6-month followup showed statistically … Statistically significant improvements in all clinical scores (International Knee
Documentation Committee
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-final-executive-summary.pdf
July 01, 2025 - downgraded to low SoE because of inconsistencies in the findings (e.g., that
medium viscosity fibers had statistically … significant strong associations but both low and
high viscosity fibers did not). … FOS and control arms does appear to increase
with larger doses of FOS (with the only within-study statistically … significant difference
found with 25 g/day FOS), meta-regression did not confirm an association with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
December 01, 2014 - RT-Associated Toxicities
Three studies of IMRT compared with 3DCRT in
the regimen of CCRT showed statistically … significant for at least one timepoint. … Statistically significant differences
were inconsistently reported for overall survival, local
control … We realize that, in doing so, we excluded evidence from
an RCT performed in China that showed a statistically … the only
study that has shown a statistically significant survival
benefit of one RT modality compared
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
June 07, 2013 - significant. … We have revised to indicate that there was a trend,
but that it was not statistically significant. … significant. … The results of these analyses were statistically
significant and reported as such in the Results
section … The results of these analyses were statistically
significant and reported as such in the Results
section
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
March 26, 2013 - significant benefit for OMBP with colon
surgery (for a systematic review see Guenaga et al.1); for … significant benefit in favor of OMBP in terms of
anastomotic leaks, other surgical complications, or … We do not plan to statistically
combine single-group and comparative studies. … Heterogeneity will be considered statistically significant when the p-value of the Q statistic is P … significant result, including “true”
heterogeneity between smaller and larger studies, other biases
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - Statistically significant difference
between groups for quality of life (SF-36
PCS) that did not reach … No
significant differences when compared with
golimumab. … 2009
2,183 early
stage RA
patients
infection and risk of
malignancy in TNFi'
users was not
statistically … Statistically significant difference
between groups for quality of life (SF-36 PCS) that did
not reach … MTX :No clinically significant difference
for functional capacity.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - Statistically significant difference
between groups for quality of life (SF-36
PCS) that did not reach … No
significant differences when compared with
golimumab. … 2009
2,183 early
stage RA
patients
infection and risk of
malignancy in TNFi'
users was not
statistically … Statistically significant difference
between groups for quality of life (SF-36 PCS) that did
not reach … MTX :No clinically significant difference
for functional capacity.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
December 14, 2017 - significant improvements from baseline were noted in these
aspects across studies at one or more doses … significant reductions in
uterine bleeding and statistically significant improvements in
women’s symptom … Treatment with Ulipristal acetate, as compared with placebo,
also resulted in clinically significant … Are the sample sizes significant? … Few measures were statistically significant (two out of 17 calculations
reported) and ranged from no
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
June 01, 2012 - In testing for a statistically significant difference between the diagnostic accuracy
of testing modalities … Sensitivity analyses exploring mixed populations of women with known and no known
CAD showed no statistically … significant difference in the sensitivities and specificities
from our primary analysis. … analysis exploring the prevalence of CAD across the
different NIT modality studies also showed no statistically … significant difference.
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Studies rated “poor” have significant flaws that
imply biases of various types that may invalidate … None
++
QoL = quality of life; SOE = strength of evidence
Effect size: none (i.e., no effect/no statistically … tricyclic antidepressant;
WAE = withdrawal due to adverse event
Effect size: none (i.e., no effect/no statistically … = strength of evidence; WAE = withdrawal due to adverse event
Effect size: none (i.e., no effect/no statistically … strength of evidence; WAE =
withdrawal due to adverse event
Effect size: none (i.e., no effect/no statistically
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_disposition.pdf
December 09, 2014 - Regardless, absent a
statistically significant p-value for
a relative effect size, one cannot
ascribe … the strongest evidence, and several
poor quality non-RCTs, the fact that
the RCT did not show a statistically … significant
reduction of late grade > xerostomia. … One of
the three studies showed a
statistically significant reduction in
dysphagia with IMRT as compared … While not considered statistically significant,
two other studies supported the reduction in
dysphagia
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Available evidence suggests that Mobi-C appears to provide significant
improvements in the clinical … related to the device; in
the ACDF group, 23 serious adverse events were noted in 13 patients, a statistically … Statistically
significant improvements in the WOMAC and Numeric Rating Scale scores were observed in … who were treated with three intra-articular PRP
injections every 2 weeks, 6-month followup showed statistically … Statistically significant improvements in all clinical scores (IKDC form, EQ VAS
13
quality
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_policymaker.pdf
August 01, 2016 - insufficient
* An NA entry for NNT indicates that the relative risk (95% confidence interval) was not statistically … significant and that an NNT was not calculated.
** The composite endpoint comprises all-cause readmission