-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - criteria
at 1 year (odds ratio [OR], 1.43; 95-percent confidence
interval [CI], 1.15-1.77, P = 0.001), but statistical … Although not all results reached statistical significance,
anakinra had consistently lower response rates … group treated with biologics had poorer baseline
characteristics than the methotrexate group; once
statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-high-risk-drugs-rapid-response.pdf
January 01, 2024 - associated with lower rates of thromboembolic events,
although the latter between-group difference reached statistical … usual care; while it also reduced thromboembolic events, the between-group difference
did not reach statistical … Given the relatively low frequency of these
events, the meta-analyses may have lacked adequate statistical … group had
fewer thromboembolism events
than the control group, but the
difference did not reach
statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
October 01, 2015 - 0.88; 95% CI, 0.71 to
1.08) or progression (1 trial; RR, 0.76; 95% CI, 0.17 to
3.30) did not reach statistical … lower doses, but most estimates were imprecise
and did not reach statistical significance. … carcinoma;
NMP22 = nuclear matrix protein 22.
41
Limitations of the Review Process
Substantial statistical … Regardless of the method
used, meta-analyses based on small numbers of trials
can underestimate statistical … Although statistical heterogeneity remained present in
some analyses, with some unexplained outlier
-
effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
October 01, 2007 - Key Words: comparative study, regression analysis, statistical
models, propensity score, bias (epidemiology … In theory, even if the Kaplan–Meier
estimate is sufficient, a Cox model would improve statistical
efficiency … experience,
however, unless the Cox model is extended to include post-
baseline information, the gains in statistical … Currently a major draw-
back is the lack of statistical software for implementing these
methods. … Some uses of statistical models in
connection with the nonresponse problem.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
November 30, 2011 - ascertaining exposures, potential confounders, and outcomes; and whether they
performed appropriate statistical … determine the appropriateness of meta-analysis, the clinical and
methodological diversity and assessed statistical … We will use standard
2
tests to assess the presence of statistical heterogeneity among studies, … Statistical heterogeneity will be
explored by using subgroup analysis or meta-regression. … When statistical meta-analysis is not possible, we will group studies by similarity of
intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
August 10, 2010 - Treatment of preschoolers
Diagnosis of preschoolers may often not adhere to strict DSM (Diagnostic and
Statistical … treatment time is
equal to or greater than
12 months
• Descriptive Statistics
Outcomes Numerical or statistical … results of any
effectiveness or adverse
event outcomes
Numerical or statistical
results of any … settings, funding sources, treatments (type, dose, duration, and provider),
methodological limitations, statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-tables-f1-2.xlsx
January 01, 2024 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other
-
effectivehealthcare.ahrq.gov/sites/default/files/mcda-johnson.pdf
August 27, 2012 - Statistical model estimates preference weights consistent with observed choices. … endpoints
– Surrogate markers
– Risk concepts
Consensus among researchers
– Experimental design
Statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
September 01, 2021 - We did not conduct statistical and graphical methods for assessing for
small sample effects (a potential
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
July 01, 2024 - We derived
COE from statistical rather than clinical significance or effect magnitude, in part because … across trials)
cDowngraded one level for study limitations (one or more trials did not provide adequate statistical … validated scales or
thresholds for clinical importance exist which makes it difficult to translate statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
May 01, 2006 - Layout 1
Background
Anemia (deficiency of red blood cells)
occurs in 13-78 percent of patients
undergoing treatment for solid tumors and
30-40 percent of patients treated for
lymphoma. Tumor type, treatment
regimen, and history of prior cancer
therapy influence the risk and severity of
anemia. For example, among pa…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
December 01, 2011 - Seventeen
studies (3,960 patients), mostly of fair quality, indicated
no statistical differences in efficacy … In addition, the more
advanced statistical analysis that we were able to do for
indirect comparisons
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
January 01, 2012 - Meta-analyses showed statistical
heterogeneity at 6 and 12 months. … These were nonsignificant or of
uncertain statistical significance. … Both reported findings that were
nonsignificant or of uncertain statistical significance. … These studies reported findings that were
nonsignificant or of uncertain statistical significance. … population, setting, interventions, and comparison groups; appropriate measurement of outcomes; appropriate statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
August 01, 2016 - questions (e.g., related to uncertainty of dietary
assessment measurements).15-17
Data Synthesis
Statistical … confidence that
10
the conclusion would remain stable with future RCTs and
subsequent greater statistical … All 19 other analyses were not
statistically significant (or no statistical difference was
reported … estimate would remain suggestive of no effect with the addition of future trial data (and
greater statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
August 01, 2013 - graphical displays and test statistics
(Q and I2 statistics), while recognizing that the ability
of statistical … Dabigatran increases
MI risk, although this finding did not reach statistical
significance (low strength … infarction 1 (12,037) SOE = Low
Dabigatran increased risk, although the difference did not
reach statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
March 01, 2012 - Statistical
heterogeneity was addressed using the I2 statistic. … A higher level of
statistical heterogeneity was detected in the evaluation
of PE. … A higher level of statistical heterogeneity was
detected in the evaluation of proximal DVT and major … I2: Measure of degree of variation due to statistical
heterogeneity. … Statistical Heterogeneity: Variability in the observed
effects among studies in a meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
December 31, 2017 - In the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5),1 PTSD
criteria … Diagnostic and statistical manual of mental disorders.
5th ed. … Diagnostic and Statistical Manual of Mental
Disorders: DSM-IV-TR. … Diagnostic and statistical manual of mental disorders,
fourth edition, text revision. … DSM = Diagnostic and Statistical Manual; PTSD = posttraumatic stress disorder.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - searches indicate that an updated systematic review would address these issues
by attaining higher statistical … synthesis
of the relevant existing evidence, with a focus on interaction effects, may increase the statistical … , setting, interventions,
and comparison groups; appropriate measurement of outcomes; appropriate statistical … tests, except those for heterogeneity, statistical significance will be
defined as two-sided p < 0.05 … Statistical methods for assessment of added
usefulness of new biomarkers.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
April 01, 2012 - Supplement–
drug interactions were examined by investigating evidence
of statistical and pharmacokinetic … Statistical
heterogeneity was assessed using Cochran’s Q (α = 0.10)
and the I2 statistic. … No study analyzed statistical interactions between a
supplement and a cardiovascular drug in terms of … Statistical interaction data were not reported in any
pharmacokinetic study. … When possible, comparative effectiveness studies
should include a statistical analysis for supplement
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
September 20, 2013 - comparison of studies added in the update versus studies included in the original report.27,
28
Statistical … studies agree, therefore the data are consistent); instead, we will assess the
direction, magnitude, and statistical … For reporting
bias, we will make qualitative dispositions rather than perform formal statistical tests … Altman
DG,
Gotzsche
PC,
et
al;
Cochrane
Bias
Methods
Group/
Cochrane
Statistical … Diagnostic
statistical
procedures
in
medical
meta-‐analyses.