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1. Quantitative Synthesis: Chapter 4. Quantifying, Testing, and Exploring Statistical Heterogeneity (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
   July 01, 2019 - Quantifying, Testing, and Exploring Statistical Heterogeneity Quantitative Synthesis Chapter 4. … Quantifying, Testing, and Exploring Statistical Heterogeneity Prepared for: The Agency for Healthcare … Learning objective Statistical heterogeneity • Statistical heterogeneity occurs when estimates across … heterogeneity tests statistical for statistical heterogeneity in meta-analysis is Q:11 ► Q is computed … Quantifying, Testing, and Exploring �Statistical Heterogeneity Learning objective Statistical heterogeneity

2. Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
   February 01, 2018 - Choice of Statistical Model for Combining Studies Quantitative Synthesis Chapter 3. … The statistical basis of meta-analysis. Stat Methods Med Res. 1993;2(2):121-45. … Choice of Statistical Model for Combining Studies Slide Number 2 Statistical models for meta-analysis … Statistical models for meta-analysis� Recommendations for �Chapter 3. … Statistical models for meta-analysis� Author References

3. Slide 1
   effectivehealthcare.ahrq.gov/sites/default/files/study-size-planning-chapter-9.pptx
   January 01, 2013 - power) for any subgroup analyses Specify the expected precision (or statistical power) as sensitivity … power) for any unplanned subgroup analyses; and specify the expected precision (or statistical power … a prespecified hypothesis and adequate statistical power. … Needed study size depends on the chosen type 1 error rate (α) and required statistical power. … Specify the expected precision (or statistical power) for any planned subgroup analyses.

4. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
   July 01, 2019 - Performance of statistical methods for meta-analysis when true study effects are non-normally distributed … are not concerns. ► Chapter 4 covers statistical heterogeneity in detail • Statistical heterogeneity … http://www.training.cochrane.org/handbook Assessing statistical heterogeneity • I2: proportion of … Performance of statistical methods for meta-analysis when true study effects are non-normally distributed … heterogeneity Assessing statistical heterogeneity Pooling decision tree (1) Pooling decision tree

5. Covariate Selection for Observational Comparative Effectiveness Research
   effectivehealthcare.ahrq.gov/sites/default/files/considerations-for-statistical-chapter-10.pptx
   January 01, 2013 - Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds.

6. Ch 9-User-Guide-To-Ocer 130129 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
   September 21, 2012 - This is problematic when investigators interpret study findings in terms of the statistical significance … models.4 Calculating statistical power requires specification of several investigator choices and … Finally, needed study size depends on the chosen Type I error rate (a) and the required statistical … o Specify the expected precision (or statistical power) for any planned subgroup analyses. … Stata Statistical Software: Release 11. College Station, TX: StataCorp; 2009. 3. Hintze, J.

7. Slide 1
   effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
   January 01, 2013 - significance Describe how confounding will be addressed Describe statistical approaches that will be … Restriction of RCTs to homogeneous groups improves statistical power. … It should also be noted that a statistical test of interaction does not correspond to an assessment of … It is important to ensure adequate statistical power for confirmatory subgroup analyses. … It is important to ensure adequate statistical power to detect subgroup effects and to appropriately

8. Slide 1
   effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
   January 01, 2013 - Observational studies and statistical models rely on assumptions ranging from how a variable is defined … to how a statistical model is chosen and parameterized. … Consider the use of more than one cohort definition or statistical approach. … Cohort Definition and Statistical Approaches Cohort Definition and Statistical Approaches It can … Statistical software-based Statistical software-based approaches can be helpful where the association

9. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
   October 01, 2010 - Statistical heterogeneity: variability in observed treatment effects across studies. … These decisions require clinical insights as well as statistical expertise. … A p-value of 0.10 instead of 0.05 could be used to determine statistical significance. … Statistical power analysis for the behavioral sciences. Hillsdale, NJ: L. … A comparison of statistical methods for meta-analysis. Stat Med 2001;20:825–840. 37.

10. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - Statistical heterogeneity: variability in observed treatment effects across studies. … These decisions require clinical insights as well as statistical expertise. … A p-value of 0.10 instead of 0.05 could be used to determine statistical significance. … Statistical power analysis for the behavioral sciences. Hillsdale, NJ: L. … A comparison of statistical methods for meta-analysis. Stat Med 2001;20:825–840. 37.

11. Quantitative Synthesis: Learning Objectives and Recommendations (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-learning-objectives-recommendations.pdf
    July 01, 2019 - statistical heterogeneity in all meta-analyses … A comparison of statistical methods for meta‐analysis. Stat Med 2001;20(6):825-40. … The statistical basis of meta-analysis. Stat Methods Med Res. 1993;2(2):121-45. … Statistical models for meta-analysis� Recommendations for �Chapter 4. … Statistical heterogeneity Recommendations for �Chapter 5.

12. Suppl-2-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
    January 01, 2011 - The graphical separation rules linking the causal assumptions encoded in a diagram to the statistical … The rules linking the structure of the graph to statistical independence are called the d-separation … Conditioning on a collider by either statistical adjustment or selection into the study can generate … Confounders, unfortunately, cannot be selected based on statistical associations alone because some … Section 1.5: Causal Versus Statistical Terminology.

13. Statistical Design and Analytic Considerations for N-of-1 Trials (Chapter 4) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-1

14. App-E-Opioid-Chronic-Pain-Surveill-Report-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveill-report-1.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

15. Methods Guide for Comparative Effectiveness Reviews - Expanded Guidance on Selected Quantitative Synthesis Topics (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - Statistical Efficiency in Clinical Trials Composite outcomes can improve statistical efficiency, increasing … Statistical and clinical homogeneity of the components should be verified. … Summary • Composite outcomes typically increase statistical efficiency. … Statistical heterogeneity Statistical tests Specify how statistical heterogeneity is assessed and … Statistical power analysis for the behavioral sciences, 2nd ed.

16. App-E-Opioid-Chronic-Pain-Surveillance-Report-2 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-2.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

17. App-E-Opioid-Chronic-Pain-Surveillance-Report-3 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-3.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

18. Gastric-Cancers-Supplementary-App-D (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
    January 01, 2023 - Lack of access to a pre-specified statistical analysis plan raises some uncertainty. … No protocol or statistical analysis plan is available, but selective reporting analysis selected on … No masking of outcome assessment, and no protocol or statistical analysis plan is available, but standard … some bias for outcome assessment ITACA-S OS Low Low Low Low Low Low open label, but had pre-defined statistical … regarding blinding ITACA-S Grade 3 to 5 AEs Low Low Low Low Low Low open label, but had pre-defined statistical

19. Ch 10-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
    January 01, 2011 - 135 Abstract This chapter provides a high-level overview of statistical analysis considerations for … Considerations for Statistical Analysis Patrick G. Arbogast, Ph.D. … While this chapter provides a high-level summary of considerations and issues for statistical analysis … Considerations for Statistical Analysis 9. Lumley T, Kronmal R, Ma S. … Statistical Analysis with Missing Data. 2nd edition.

20. CER 215 Executive Summary: Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
    March 01, 2019 - SOE was graded for the calculated effect estimates with interpretation based on statistical significance … Adverse events of antidepressants versus placebo or no therapy: summary statements based on findings and statistical … SSRI: selective serotonin reuptake inhibitor; vs=versus; XR=extended release a Conclusions based on statistical … SSRI: selective serotonin reuptake inhibitor; vs=versus; XR=extended release a Conclusions based on statistical … Interpretations of findings were made based on statistical significance, which may miss small differences