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  1. www.ahrq.gov/sites/default/files/wysiwyg/evidencenow/results/research/physician-survey-post-intervention-nw.pdf
    January 01, 2014 - Statin therapy is now recommended for patients who meet one of the following criteria: 1. …      Patient with a primary elevation of LDL >190mg/dL should be prescribed a statin     … In determining whether to recommend statin therapy, do you prefer a risk cut-off higher than 7.5% (using … : Off Primary elevation of LDL >190mg/dL should be prescribed a statin: Off Diagnosis of DM, between … 40-75 years old, with LDL between 70-189 mg/dl, and no diagnosis of ASCVD should be prescribed a statin
  2. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan98/statin-use-in-adults-preventive-medication-november-2016
    May 02, 2014 - Share to Email Print archived Final Research Plan Statin … The arrows for statin treatment also address how benefits and harms vary according to the potency of … statin treatment (Key Question 3). … How do benefits and harms vary according to potency of statin treatment? … KQ 2: Placebo KQ 3: Higher vs. lower-potency statin therapy   Outcomes
  3. cds.ahrq.gov/sites/default/files/workgroups/236/may-2017-cholesterol-wg-notes.docx
    January 01, 2017 - Lookback Periods, Notifications for the USPSTF Artifacts and Value Sets · CDS Connect Pilot Overview · Statin … · Different perspectives were shared on the wording of the notification: · Use “consider” statin for … 7.5%-9.5% risk and possibly use “discuss” statin for a risk > 10%. … · A statement like: “Start low-medium intensity statin based on outcome of discussion and shared decision … making with patient” would be better than simply stating “Start low-medium intensity statin”.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
    December 31, 2013 - type, and statin dose. … inhibitor (statin) Lovastatin Mevacor® Oral HMG-CoA reductase inhibitor (statin) Pitavastatin Livalo … + ezetimibe vs. statin monotherapy; statin + nicotinic acid vs. statin monotherapy). … Our comparison of a lower dose statin in combination therapy with higher dose statin monotherapy will … be statin specific.
  5. digital.ahrq.gov/ahrq-funded-projects/patient-centered-outcomes-research-clinical-decision-support-cds-connect/citation/statin
    January 01, 2023 - Implementation guide: statin therapy for the prevention and treatment of cardiovascular disease (CVD) … Implementation guide: statin therapy for the prevention and treatment of cardiovascular disease (CVD)
  6. cds.ahrq.gov/sites/default/files/workgroups/231/apr-2017-cholesterol-wg-notes.docx
    January 01, 2017 - The ACC/AHA provides a statin recommendation for risk scores 5-<=7.5% and USPSTF provides one for 7.5 … for a stronger recommendation and “discuss” statin for a lesser one) … You might not want to trigger a recommendation to lower statin therapy if a patient was started on a … high intensity statin b/c their LDL was > 190. … This will be consistent with the statin artifact also.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
    March 10, 2010 - , the equipoise is whether to add another non-statin drug vs. to change to a more potent statin … this … had multiple statin arms. … doses that are closer/equal to the statin (i.e. statin) in the other arm will be used for dose-non … combination versus statin monotherapy." … to the same dose of statin plus ezetimibe.
  8. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/lipid-disorders-in-children-screening
    July 18, 2023 - Observational studies suggest that statin treatment for FH starting in childhood or adolescence reduces … Most of the evidence for statin harms is from small, short-term studies. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Statin use and the risk of type 2 diabetes mellitus in children and adolescents. … Early initiation of statin treatment in children with familial hypercholesterolaemia.
  9. cds.ahrq.gov/sites/default/files/cds/artifact/18/Enhanced%20CDS%20Artifact%20Based%20on%20Pilot%20Implementation_Final.docx
    October 01, 2017 - Initial Definition of the Statin Use Artifact 4 3. … To enhance and inform the CDS Connect artifact development process, one artifact (i.e., Statin Use for … Initial Definition of the Statin Use Artifact The initial definition of the Statin Use artifact was … Use for the Primary Prevention of CVD in Adults (hereinafter “Statin Use”) artifact. … · Low Intensity Statin Initial Definition Low intensity statin semantic clinical drugs (SCD) and
  10. www.uspreventiveservicestaskforce.org/home/getfilebytoken/rQBBkz9CrHh4vp7ZnEkF-t
    July 18, 2023 - 1 What is the optimal timing of statin treatment initiation in FH? … Most of the evidence for statin harms is from small, short- term studies. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Statin use and the risk of type 2 diabetes mellitus in children and adolescents. … Early initiation of statin treatment in children with familial hypercholesterolaemia.
  11. digital.ahrq.gov/population/implementer
    August 01, 2024 - Research Clinical Decision Support (CDS) Connect Implementation guide: USPSTF statin … Implementation guide: USPSTF statin use for primary prevention of CVD in adults. … Outcomes Research Clinical Decision Support (CDS) Connect Implementation guide: statin … Implementation guide: statin therapy for the prevention and treatment of cardiovascular disease (CVD)
  12. www.ahrq.gov/sites/default/files/wysiwyg/evidencenow/results/research/member-codebook-baseline.pdf
    January 01, 2014 - Statin therapy is now recommended for patients who meet one of the following criteria: 1. … the following statement: Riskcalc_guidelines Optional item In determining whether to recommend statin … include an ACE or ARB for black patients: Off Patients diagnosed with ASCVD should be prescribed a statin … : Off Patient with a primary elevation of LDL >190mg/dL should be prescribed a statin: Off Patient … : Off In determining whether to recommend statin therapy, I prefer a risk cut-off higher than 7: 5%
  13. meps.ahrq.gov/data_files/publications/st407/stat407.shtml
    June 01, 2013 - age 40, the inflation adjusted average cost per drug purchase of a prescription anti-hypertensive and statin … Total number of prescribed drug purchases of anti-diabetic, anti-hypertensive, or statin drugs for persons … Total expenditures for prescribed drug purchases of anti-diabetic, anti-hypertensive, or statin drugs … Mean expense per drug purchase of anti-diabetic, anti-hypertensive, or statin drugs for persons under … Mean expense per person under age 40 purchasing one or more anti-diabetic, anti-hypertensive, or statin
  14. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-screening-for-familial-hypercholesterolemia/lipid-disorders-in-children-screening-july-2016
    August 09, 2016 - Eight placebo trials of statin drugs (n = 1071; 6–104 weeks) found low-density lipoprotein cholesterol … Mean DHEAS levels were 8.4 (SD, 3.0) μmol/L among statin-treated males and 5.6 (SD, 3.2) μmol/L among … statin-treated females, compared with 12.9 (SD, 4.9) μmol/L among unaffected male siblings and 6.8 ( … Optimal age of statin initiation in children with FH is a matter of expert debate. … Statin treatment in children with familial hypercholesterolemia: the younger, the better.
  15. cds.ahrq.gov/sites/default/files/workgroups/216/jan-2017-cholesterol-wg-notes.docx
    January 01, 2017 - with ASCVD: · Do not present the calculated risk for ASCVD patients, but provide recommendation for statin … score is invalid for these patients, as they already have ASCVD; however, they would still benefit from statin … preferred tool based on their practice and intention for ascertaining risk (e.g., post initiation of a statin … decision making must include not just the risk of cardiovascular disease, but the potential impact of statin … ) The group agreed on pursuing development of artifacts in alignment with other quality measures: · Statin
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
    October 01, 2015 - to intravenous saline, 4 comparing a statin plus N-acetylcysteine to N-acetylcysteine, and 6 other … comparisons of statin versus statin, statin by dose, or statins plus other agents); 5 RCTs (N = 3,647 … Statins The SOE was moderate in studies that compared use of a statin plus intravenous fluids versus … fluids alone, showing a clinically important and statistically significant reduction in CIN with statin … in patients receiving LOCM or IOCM, the best evidence of potential benefit was seen with use of a statin
  17. www.uspreventiveservicestaskforce.org/home/getfilebytoken/dCH2CMqVyAzf4eyj-ch6H3
    August 09, 2016 - Eight placebo trials of statin drugs (n = 1071, 6-104 weeks) found low-density lipoprotein cholesterol … Statins Three of 8 statin trials were longer than 6 months: 2 were of 48 weeks’ duration,25,26 and 1 … Optimal age of statin initiation in children with FH is a matter of expert debate. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Early statin therapy restores endothelial function in children with familial hypercholesterolemia.
  18. cds.ahrq.gov/sites/default/files/workgroups/221/feb-2017-cholesterol-wg-notes.docx
    January 01, 2017 - Welcome · Discuss Remaining Repository Questions · Clarify 10-Year Risk Assessment Details · Discuss Statin … Discuss Statin Therapy for the Prevention and Treatment of CVD eCQM/CDS Artifact Quality Insights of … They provided an overview of a statin therapy measure available as a registry measure under the Physician … members’ feedback on the appropriate triggers, expression logic, and interventions to represent the statin … Discuss Statin Therapy for the Prevention and Treatment of CVD eCQM/CDS Artifact Not discussed.
  19. effectivehealthcare.ahrq.gov/products/high-cholestorol-medicines-update/research
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
    January 01, 2013 - The mean SBP was significantly lowered in the supplement- statin combination group (grade: low) in … Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and … Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin- treated patients … Vascepa had greater TG-lowering effects on those with higher- efficacy statin regimens and/or higher … Inclusion criteria: diabetes or hypercholesterolemia under statin treatment, and at least 1 of the

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