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1. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/6dqHx6xQGq9GUv92rZUf2q
   August 01, 2022 - Statin Use for the Primary Prevention of Cardiovascular Disease in Adults The USPSTF recognizes … Clinician Summary of USPSTF Recommendation Statin Use for the Primary Prevention of Cardiovascular … smoking) and an estimated 10-year cardiovascular disease (CVD) risk of 10% or greater: Initiate a statin … is smaller, so clinicians should selectively offer a statin, taking patient values and preferences … • To achieve the full benefits of statin use, it is essential to equitably improve statin use in

2. Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication
   August 23, 2022 - To achieve the full benefits of statin use, it is essential to equitably improve statin use in both women … Treatment and Statin Intensity There are limited data directly comparing the effects of different statin … or by titration of statin therapy to a target LDL-C level vs use of a fixed statin dose. … therapy or based on statin intensity. … and mortality Harms of statin use Convincing evidence that the harms of statin use in

3. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTJ_Zj3TAkhx45wWUDtNyt
   May 01, 2021 - Treatment and Statin Intensity There are limited data directly comparing the effects of different statin … Summary of USPSTF Rationale Rationale Assessment Benefits of statin use • Convincing evidence that statin … Harms of statin use • Convincing evidence that the harms of statin use in adults aged 40 to 75 years … , or by titration of statin therapy to a target LDL-C level vs use of a fixed statin dose. … therapy or based on statin intensity.

4. Final Recommendation Statement: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/statin-use-in-adults-preventive-medication
   August 23, 2022 - Treatment and Statin Intensity There are limited data directly comparing the effects of different statin … statin use 15 compared with White adults. … or by titration of statin therapy to a target LDL-C level vs use of a fixed statin dose. … therapy or based on statin intensity. … and mortality Harms of statin use Convincing evidence that the harms of statin use in

5. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/JcwfLrEqaaxP6DPEQvxgUs
   February 18, 2020 - statin use in adults aged 40 to 75 years are small. … The majority (>80%) use a statin alone.29 The Table. … Statin Regimens Used in Available Trials Statin Dose, mga Low Moderate High Atorvastatin 10-20 40- … There are limited data on different statin dosing strategies; trials that directly compare titrated statin … Harms of Statin Use In randomized trials of statin use for the primary prevention of CVD, statin therapy

6. Evidence Summary: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/statin-use-in-adults-preventive-medication
   August 23, 2022 - Study Selection: Randomized clinical trials on statins vs placebo or no statin and statin intensity … Randomized clinical trials of statin therapy vs placebo or no statin, statin dosing strategies to target … statin dose. … Statin therapy, vs placebo or no statin, was not significantly associated with increased risk of study … therapy and higher- vs lower-intensity statin therapy; to more definitively determine whether statin

7. Final Research Plan: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/statin-use-in-adults-preventive-medication
   November 05, 2020 - to WhatsApp Share to Email Print Final Research Plan Statin … Do the benefits of statin treatment vary in subgroups defined by demographic, clinical, or socioeconomic … What are the harms of statin treatment?     b. … Do the harms of statin treatment vary in subgroups defined by demographic, clinical, or socioeconomic … How do the benefits and harms of statin treatment vary according to its intensity?

8. Archived: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication-november-2016
   November 13, 2016 - statin use in adults aged 40 to 75 years are small. … There are limited data on different statin dosing strategies; trials that directly compare titrated statin … Harms of Statin Use In randomized trials of statin use for the primary prevention of CVD, statin therapy … adults 76 years and older who are not already taking a statin. … to "which population should be prescribed statin therapy?"

9. Archived: Evidence Summary: Statins for Prevention of Cardiovascular Disease in Adults: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-statins/statin-use-in-adults-preventive-medication-november-2016
   November 13, 2016 - We included randomized trials of statin therapy vs placebo or no statin and assessed all-cause mortality … Benefits of Statin Treatment Key Question 1a. … What are the harms of statin treatment? … How do benefits and harms vary according to statin treatment potency? … statin therapy is associated with increased diabetes or cataract risk; and to determine how statin intensity

10. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review fo the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/k_QR3hvh2jVSPPLu6Q6m6r
    November 13, 2022 - STUDY SELECTION Randomized clinical trials on statins vs placebo or no statin and statin intensity in … Randomized clinical trials of statin therapy vs placebo or no statin, statin dosing strategies to target … statin dose. … based on trials of statins vs placebo or no statin stratified according to statin intensity showed no … therapy and higher- vs lower- intensity statin therapy; to more definitively determine whether statin

11. Figure. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Clinical Summary (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/yBxQssfCeRcD6BBeP2QjdQ
    Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Clinical Summary Figure. … Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Clinical Summary Population … Considerations for Implementation The likelihood that a patient will benefit from statin use depends … discuss with patients the potential risk of having a CVD event and the expected benefits and harms of statin … concludes that the evidence is insufficient to determine the balance of benefits and harms of initiating statin

12. Statins for Prevention of Cardiovascular Disease in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/mk-eb9VtB_jx885wnjuzk3
    January 01, 2024 - We included randomized trials of statin therapy vs pla- cebo or no statin and assessed all-cause mortality … Benefits of Statin Treatment Key Question 1a. … What are the harms of statin treatment? … 2 How do benefits and harms vary according to statin treatment potency? … What are the harms of statin treatment?

13. Archived: Final Research Plan: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan98/statin-use-in-adults-preventive-medication-november-2016
    May 02, 2014 - Share to Email Print archived Final Research Plan Statin … The arrows for statin treatment also address how benefits and harms vary according to the potency of … statin treatment (Key Question 3). … How do benefits and harms vary according to potency of statin treatment? … KQ 2: Placebo KQ 3: Higher vs. lower-potency statin therapy   Outcomes

14. Evidence Summary: Lipid Disorders in Children and Adolescents: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/lipid-disorders-in-children-screening
    July 18, 2023 - Observational studies suggest that statin treatment for FH starting in childhood or adolescence reduces … Most of the evidence for statin harms is from small, short-term studies. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Statin use and the risk of type 2 diabetes mellitus in children and adolescents. … Early initiation of statin treatment in children with familial hypercholesterolaemia.

15. Screening for Lipid Disorders in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/rQBBkz9CrHh4vp7ZnEkF-t
    July 18, 2023 - 1 What is the optimal timing of statin treatment initiation in FH? … Most of the evidence for statin harms is from small, short- term studies. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Statin use and the risk of type 2 diabetes mellitus in children and adolescents. … Early initiation of statin treatment in children with familial hypercholesterolaemia.

16. Archived: Evidence Summary: Screening for Familial Hypercholesterolemia: Lipid Disorders in Children and Adolescents: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-screening-for-familial-hypercholesterolemia/lipid-disorders-in-children-screening-july-2016
    August 09, 2016 - Eight placebo trials of statin drugs (n = 1071; 6–104 weeks) found low-density lipoprotein cholesterol … Mean DHEAS levels were 8.4 (SD, 3.0) μmol/L among statin-treated males and 5.6 (SD, 3.2) μmol/L among … statin-treated females, compared with 12.9 (SD, 4.9) μmol/L among unaffected male siblings and 6.8 ( … Optimal age of statin initiation in children with FH is a matter of expert debate. … Statin treatment in children with familial hypercholesterolemia: the younger, the better.

17. Lipid Screening in Childhood and Adolescence for Detection of Familial Hypercholerolemia: Evidence Report and Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/dCH2CMqVyAzf4eyj-ch6H3
    August 09, 2016 - Eight placebo trials of statin drugs (n = 1071, 6-104 weeks) found low-density lipoprotein cholesterol … Statins Three of 8 statin trials were longer than 6 months: 2 were of 48 weeks’ duration,25,26 and 1 … Optimal age of statin initiation in children with FH is a matter of expert debate. … Statin treatment in children with familial hypercholesterolemia: the younger, the better. … Early statin therapy restores endothelial function in children with familial hypercholesterolemia.

18. Screening for Dyslipidemia in Younger Adults: A Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/SaASReVeD_fpHZQbeBZD5s
    October 01, 2016 - Therefore, the USPSTF commissioned a separate evidence review on the use of statin therapy for cardio … ds=1&s=statin. … ds=1&s=statin http://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryDraft/statin-use-in-adults-preventive-medication1 … ds=1&s=statin http://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryDraft/statin-use-in-adults-preventive-medication1 … ds=1&s=statin mailto:chour@ohsu.edu http://www.annals.org References 1.

19. Recommendation: Lipid Disorders in Children and Adolescents: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/lipid-disorders-in-children-screening
    July 18, 2023 - Abnormal liver and musculoskeletal laboratory values were reported with statin use; however, most trials … No more than 60% of participants in the statin group achieved goal in 4 trials reporting this metric. … The largest trial (n = 214), with 2-year follow-up, reported no cases in the statin group and only 2 … There were no significant differences in Tanner staging or hormonal adverse events between statin and … Children with confirmed FH who started statins in youth (mean statin initiation age, 14.0 [SD, 3.1] years

20. High-Priority Evidence Gaps For Clinical Preventive Services: 7th Annual Report to Congress (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annual-report-to-congress-2017%20(2).pdf
    January 01, 2017 - Statin Use for the Primary Prevention of Cardiovascular Disease in Adults Age 76 Years and Older 1. … Younger Than Age 3 Years ......................................................................13 Statin … Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. … (Grade B) Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive … Clinicians may choose to offer a low- to moderate-dose statin to certain adults without a history of