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21. Kidney-Disease-Medicine Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
    October 01, 2012 - No statin trials reported clinical outcomes data for patients with albuminuria. … Other Experts Conclusion from SCEPC In RCTs that compared high- versus low-dose treatment (ARB, statin … creatinine clearance, screening such patients for impaired eGFR could lead to early initiation of statin … No statin trials reported clinical outcomes data for patients with albuminuria. … New Evidence: In RCTs that compared high- versus low- dose treatment (ARB, statin

22. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
    August 01, 2016 - One trial found that 1.8 g/d of purified EPA ethyl ester had an additive effect on statin to reduce … Twenty subgroup analyses by statin use were reported (1 with ALA, 19 with marine oil). … All but one study found difference in effect or association based on statin use. … (1.1%) versus statin alone (0.6%, P<0.0001). … o 19 of 20 studies found no differential effect by statin co-use.

23. DEcIDE 32: The Incident User Design in Comparative Effectiveness Research (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
    May 01, 2012 - For example, when Schneeweiss and colleagues identified elderly patients who filled statin therapies … Ray and colleagues compared incident users of statin medications to two control cohorts to evaluate … When they compared incident statin users to incident users of other lipid-lowering drugs (i.e., active … and others did not.41 For example, Brookhart and colleagues found that patients who refilled their statin … prescription were more likely to seek preventive services than patients who only filled their statin

24. AHRQ Slide Template 2009 (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/reporting.ppt
    September 01, 2009 - patients and caregivers, blinded outcome assessment), time to initiation of statins, and the type of statin … T]he available clinical trial evidence supporting the use of combination therapies over higher dose statin … There are some instances, such as failure to reach targets in spite of maximal statin therapy, and populations

25. Disposition of Comments for Treatment Strategies for Patients With Peripheral Artery Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
    May 29, 2013 - and glucose control whereas in 2011 usual care might consist of blood pressure and glucose control, statin … Since 1995, the routine use of statin therapy has reduced morbidity and mortality from CV and peripheral … even if the studies comparing surgery with usual care before 1995 show benefit, given the use of statin … Moreover, three randomized controlled trials have demonstrated improvements in walking with statin … and a decision on the scope of this review was made to not include studies on ACE inhibitors and statin

26. Nephropathy-Contrast-Induced Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
    October 01, 2013 - Efficacy of short-term high-dose statin in preventing contrast-induced nephropathy: a meta-analysis … Li et al 2012{Li, 2012 #31} RCTs with and without the prevention strategy of statin administration … The use of short-term high-dose statin treatment was associated with a significant reduction in … incidence of acute renal failure requiring dialysis was not significant different after the use of statin

27. Renal-Artery-Stenosis Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
    June 01, 2012 - ; dose) Treatment duration/ Study period Primary outcome Findings 63% treatment, a statin … medical treatment (antihypertensive treatment, a statin, and aspirin only); dose:NR; (n=76) Two … period Primary outcome Findings Age:66.5 yrs; Male: 63% (antihypertensive treatment, a statin

28. Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_disposition-comments.pdf
    August 12, 2016 - the following issues but found the information difficult to access: RCT results after accounting for statin … I would have liked to see more attention to the issue of effect modification by statin and aspirin … less than 2000 mgdL who were either untreated for dyslipidemia or were using a stable dosage of a statin

29. Ch 5-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_5-user-guide-to-ocer_130129.pdf
    January 01, 2012 - For example, in a study assessing the risk of cancer in statin use,4 users of glaucoma drugs (like … patients5), were employed as an active comparison group with an aim to control for potential bias due to statin

30. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
    March 01, 2017 - Message Lipid Lowering Treatment • Evidence was insufficient to assess the effect of 5 years of statin … improvement in executive/attention/ processing speed with placebo treatment that was not found with statin … no benefit on brief cognitive test performance, executive/attention/processing speed, or memory for statin … plus fenofibrate versus statin plus placebo in adults with normal cognition.

31. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
    March 01, 2017 - Message Lipid Lowering Treatment • Evidence was insufficient to assess the effect of 5 years of statin … improvement in executive/attention/ processing speed with placebo treatment that was not found with statin … no benefit on brief cognitive test performance, executive/attention/processing speed, or memory for statin … plus fenofibrate versus statin plus placebo in adults with normal cognition.

32. Ch 2-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
    January 01, 2011 - selection bias.8, 29, 32 For example, Dormuth et al.32 examined the relationship between adherence to statin … vs. less adherent) and a variety of outcomes thought to be associated with and not associated with statin … as more adherent were less likely to experience negative health outcomes unlikely to be caused by statin … The association between statin use and outcomes potentially attributable to an unhealthy lifestyle … Statin adherence and risk of accidents: a cautionary tale.

33. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
    January 01, 2024 - Dietary interventions among existing statin users will be included ● Interventions designed to induce

34. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
    January 01, 2024 - Dietary interventions among existing statin users will be included ● Interventions designed to induce

35. Mental-Illness-Heart Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
    April 01, 2013 - 1 Comparative Effectiveness Review Number 105 Interventions To Improve Cardiovascular Risk Factors in People With Serious Mental Illness Executive Summary Background Serious mental illness (SMI) is defined generally as a major mental or behavioral disorder, causing substantial impairment in multiple areas …

36. Slide 1
    effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
    January 01, 2013 - Example: In a study assessing the risk of cancer in statin users, an active comparator group of patients … on glaucoma drugs was used to control for potential bias because statin users engage in more health-seeking

37. S44 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s44.pdf
    October 01, 2007 - Indeed, both the statin policy trial and the coxib policy trial did not proceed because of controversies

38. Effectiveness of Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypothyroidism-hyperthyroidism-screening-treatment_disposition-comments.pdf
    February 01, 2012 - Effectiveness of Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism Source: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and- reports/?pageaction=displayproduct&productID=750 Published Online: February 2012 Comparative Effectiveness Research Review …

39. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-heart_research-protocol.pdf
    April 18, 2012 - ] OR "Hydroxymethylglutaryl-CoA Reductase Inhibitors" [Pharmacological Action] OR statins[tiab] OR statin

40. Microsoft Word - finapps.doc (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes-2007.pdf
    January 01, 2007 - Kidney Function Cardio- vascular Disease Qual Appl Hanzel, 200527 154/77 ≥70% 40 Aspirin, statin … A All patients received aspirin 325 mg/day and a statin to achieve LDL cholesterol <100 mg/dl. … A All patients received aspirin 325 mg/day and a statin to achieve LDL cholesterol <100 mg/dl.