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1. Statins | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/statins

2. Layout 1 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
   September 01, 2009 - Evidence comparing various doses of statin- ezetimibe, statin-fibrate, statin-niacin, and statin-BAS … , statin-BAS, and statin- omega-3 combinations. … , statin-BAS, and statin-omega-3 combinations. … the statin-fibrate, statin-niacin, statin-BAS, and statin-omega-3 combinations with respect to statin … statin-niacin, and statin-omega-3 combinations.

3. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
   September 01, 2014 - We agree that new trials with statin mono vs. statin + “add on” combo agent (e.g., ACCORD, AIM HIGH) … Statin/niacin vs statin/EZE: fewer adverse cardiac events with statin/niacin v statin/EZE (Taylor 2009 … statin combo therapies. … lower incidence of major cardiovascular events with statin+niacin than with statin+ezetimibe. … as a potent statin alone.

4. S143 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
   October 01, 2007 - We identified statin initiators and those eligible for statin initiation (based on having a physician … RESULTS There was an average of 504 (�60.0) statin initiators and 8090 (�1168) statin noninitiators … Statin Initiators and Randomly* Selected Comparators No. … Statin Initiators and Matched Comparators (Reduced Model) No. … Statin Initiators and Comparators (Expanded Model) No.

5. High-Cholestorol-Medicines-Update Executive (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
   February 01, 2014 - doses of statin could be used. … monotherapy, which enabled us to synthesize data across statin type and statin dose. … Included studies of fibrates + statin. Included studies of niacin + statin. … statin potency. … therapy with omega-3 fatty acid and statin to intensification of statin monotherapy.

6. S131 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
   October 01, 2007 - On each statin user’s index date, we sampled a subject who had not used a statin as of that date (ie, … on a statin) and prevalent users (ie, those taking a statin for some time). … Cohort 1—Incident Statin Users and Nonusers Cohort 1a—Incident statin users and nonusers matched on … We restricted cohort 1 to incident statin users, defined as no statin use in the 12 months before the … Thirty-six percent of incident statin users and 22.5% of prevalent users stopped taking their statin.

7. high-cholesterol-medicines-update-protocol-130516 (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
   December 31, 2013 - type, and statin dose. … inhibitor (statin) Lovastatin Mevacor® Oral HMG-CoA reductase inhibitor (statin) Pitavastatin Livalo … + ezetimibe vs. statin monotherapy; statin + nicotinic acid vs. statin monotherapy). … Our comparison of a lower dose statin in combination therapy with higher dose statin monotherapy will … be statin specific.

8. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
   March 10, 2010 - , the equipoise is whether to add another non-statin drug vs. to change to a more potent statin … this … had multiple statin arms. … doses that are closer/equal to the statin (i.e. statin) in the other arm will be used for dose-non … combination versus statin monotherapy." … to the same dose of statin plus ezetimibe.

9. Nephropathy-Contrast-Induced Executive (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
   October 01, 2015 - to intravenous saline, 4 comparing a statin plus N-acetylcysteine to N-acetylcysteine, and 6 other … comparisons of statin versus statin, statin by dose, or statins plus other agents); 5 RCTs (N = 3,647 … Statins The SOE was moderate in studies that compared use of a statin plus intravenous fluids versus … fluids alone, showing a clinically important and statistically significant reduction in CIN with statin … in patients receiving LOCM or IOCM, the best evidence of potential benefit was seen with use of a statin

10. Combination Therapy Versus Intensification of Statin Monotherapy: An Update | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/high-cholestorol-medicines-update/research

11. Dietary-Supplements Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
    January 01, 2013 - The mean SBP was significantly lowered in the supplement- statin combination group (grade: low) in … Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and … Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin- treated patients … Vascepa had greater TG-lowering effects on those with higher- efficacy statin regimens and/or higher … Inclusion criteria: diabetes or hypercholesterolemia under statin treatment, and at least 1 of the

12. Dietary-Supplements Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
    April 01, 2012 - In three short-term efficacy trials of omega-3 fatty acid and statin coadministration, statin adherence … The mean SBP was significantly lowered in the supplement-statin combination group (grade: low) in 22 … One RCT of 32 participants with statin-induced myopathic symptoms89 found a significantly greater number … However, a significantly elevated fasting blood glucose in the omega-3 fatty acids plus statin group … Evidence regarding benefit of coenzyme Q10 in reducing myalgia in participants with statin-induced

13. Developing and Piloting a Tool To Create Dot Plots To Summarize Pooled Data for Multiple Outcomes in Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/dot-plots-methods.pdf
    October 01, 2021 - Dot plot for dichotomous outcomes, statins versus placebo or no statin ........................ 3 Figure … focused on dichotomous outcomes; for the pilot we used pooled data for statins versus placebo or no statin … Dot plot for dichotomous outcomes, statins versus placebo or no statin Abbreviations: AE = adverse

14. Developing and Piloting a Tool To Create Dot Plots To Summarize Pooled Data for Multiple Outcomes in Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/dot-plots-methods.pdf
    October 01, 2021 - Dot plot for dichotomous outcomes, statins versus placebo or no statin ........................ 3 Figure … focused on dichotomous outcomes; for the pilot we used pooled data for statins versus placebo or no statin … Dot plot for dichotomous outcomes, statins versus placebo or no statin Abbreviations: AE = adverse

15. What do we know about how evidence of harm and benefit is communicated in other countries? (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/communicating_risk_international_king.ppt
    January 01, 2005 - What do we know about how evidence of harm and benefit is communicated in other countries? What do we know about how evidence of harm and benefit is communicated in other countries? Valerie King MD, MPH and David Hickam MD, MPH John M. Eisenberg Clinical Decisions and Communications Science Center Oregon Health &…

16. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0250_05-20-2010.pdf
    January 01, 2010 - Effective Health Care Topic Number(s): 0268a-b-c Document Completion Date: 02-25-11 1 Results of Topic Selection Process & Next Steps  Treatment of atrial fibrillation (AF) and stroke prevention in AF will go forward for refinement as systematic reviews. Primary prevention of AF will not go f…

17. Disposition of Comments for CERs 155 156 Contast-Induced Nephropathy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
    January 07, 2016 - Thank you for your comment 49 Technical Expert #3 Results Results: Statin section: Although the … section you report the statin doses used in trials but don't tell me the drug. … A new analysis has been added to the statin section comparing statin plus NAC v NAC alone. … As I understand, statin trials were conducted in a specific population. … The included studies are on subjects who are statin naive.

18. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
    May 01, 2012 - The rarity of rhabdomyolysis (estimated incidence 0.4-6.0 per 10,000 person-years among statin users … However, an observational study of rhabdomyolysis among rosuvastatin and other statin users is also … Since LDL level is a primary indication for statin therapy and higher LDL levels are anticipated to … Table 4 shows the effect of matching on the statin statistics. … A propensity score−matched cohort study of the effect of statin, mainly fluvastatin, on the occurrence

19. Kidney-Disease-Medicine Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
    January 01, 2012 - No statin trials reported clinical outcomes data for patients with albuminuria. … - In RCTs that compared high- versus low-dose treatment (ARB, statin), strict versus standard control … creatinine clearance, screening such patients for impaired eGFR could lead to early initiation of statin … Statin vs. statin (high vs. low dose) 2 trials; 4,793 patients Mortality: low ESRD: insufficient … Effectiveness of statin therapy in adults with coronary heart disease.

20. Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
    August 01, 2016 - e One study included in this meta-analysis compared a statin + sodium bicarbonate + IV saline versus