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441. Dispostion of Comments Report for Child and Adolescent Exposure to Trauma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
     February 11, 2013 - Page 27, lines 56-57, states that children were selected based on exposure to therapy (should be trauma … N/A Peer Reviewer #2 Results Note: re KQ 5 - text in ES states this is KQ 3 (typo?). … KQ4 (p. 145, lines 25-28): There appear to be some problem with the numeric citations (e.g., Line 25 states … Commentator & Affiliation Section Comment Response TEP #4 Discussion/ Conclusion The review states

442. Disposition of Comments for CER 165 Fecal Incontinence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
     March 21, 2016 - of FI may be structural (e.g., muscle damage from episiotomy or surgery)… -The 2nd paragraph also states … incontinence FI is higher in women than men but the reference from which that citation is taken actually states … inform clinical decisionmaking for the range of treatments available for FI in adults in the United States … evidence to inform clinical decisionmaking for the range of treatments for FI in adults in the United States

443. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … (racemic ketamine hydrochloride solution) is the only formulation sold commercially in the United States … psychotherapy, but unofficial sources indicate that at least 40 States offer at least partial coverage … Medicaid reimburses for telehealth in 47 states. [internet].

444. Chicago-Area DEcIDE Center (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
     May 01, 2009 - Effective Health Care Research Report Number 12 1 Introduction The United States Food and Drug … Fluoroquinolone prescribing in the United States, 1995-2000. Am J Med, 2005;118:259-68. 4. … Indices for volume of off-label use and other drug characteristics, United States, July 2005 through … Indices for volume of off-label use and other drug characteristics, United States, July 2005 through … United States, July 2005 through June 2007, IMS Health National Disease and Therapeutic Index Model

445. Disposition of Comments for CER 177 Agitation Aggression Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_disposition-comments.pdf
     March 21, 2016 - In regards to informal family caregiver, the text now states: “The caregiver is typically an informal … The text now states: “Caregiver-level interventions to address agitation/aggression intervene on the … For example the introduction to the main text now states: “Agitation and aggression are costly to … The revised text now states: “Agitation/aggression in individuals with dementia is associated with … The text now states: “The more interventions require clinical judgment, the more difficult it is to

446. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … In the United States, 34.9% of adults are obese. … Although the device is not yet approved for marketing in the United States, one cost estimate lists … , or vagus nerve block, also addressed in this report, should they become available in the United States

447. Disposition of Comments Report for Nitrous Oxide for the Management of Labor Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
     August 23, 2012 - Page ES-10, lm 47: What is meant that the standards of care are not comparable between the United States … Again, what’s the point being made that only six of the studies originate in the United States? … labor pain…” and for paracervical block it states “Provides some relief from pain of cervical dilation … The most significant barrier to use in the United States, appropriate equipment, is noted at the end … Yes, we are required to focus on care in the United States.

448. medication-assisted-treatment-protocol-160224 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
     February 24, 2016 - Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and … The changing face of heroin use in the United States: a retrospective analysis of the past 50 years. … Addressing Prescription Drug Abuse in the United States: Current Activities and Future Opportunities

449. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … approved in other nations may compete with the ReShape Duo if they receive approval in the United States … Qsymia) Unmet need: The increasing prevalence of overweight and obese populations in the United States … absorption, was the only FDA-approved antiobesity drug available for long-term use in the United States

450. Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
     April 01, 2013 - =United States. … =United States. … =United States. … Disease Burden from Viral Hepatitis A, B, and C in the United States. … United States A-1 Appendix A.

451. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1306.pdf
     January 01, 2016 - or for which some preliminary efficacy data in the target population are available) in the United States … The Mayo Foundation for Medical Education and Research (MFMER) states that T1DM risk factors include … ADA states that the disease is caused by destruction of the pancreatic beta cells and this destruction … MFMER states that all patients with T1DM require insulin therapy. … Costs for the Iluvien implant are not yet established in the United States because the product has

452. palliative-care-protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/palliative-care-tools_research-protocol.pdf
     April 14, 2016 - include systematic  reviews  of prospective, controlled  trials Language/ Country English/ United States

453. Disposition of Comments for Local Nonsurgical Therapies for Stage I and Symptomatic Obstructive Non-Small-Cell Lung Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lung-cancer-nonsurgical-therapies_disposition-comments.pdf
     June 12, 2013 - Clarity and Usability: I am a bit unsure of how this report will used to guide policy, as it clearly states … Reviewer 4 (TEP) General Comment The title states it is about local therapies for stage I lung … Unfortunately, there is no real incentive, and perhaps disincentive, in the United States market for … Summary emphasizes radiation over endobronchial interventions for endobronchial disease and incorrectly states

454. Disposition of Comments for PCA3 Testing for the Diagnosis and Management of Prostate Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_disposition-comments.pdf
     April 01, 2013 - TEP # 13 ES-11, line 20 States that searches were run on MEDLINE, however, Appendix A refers to searches … Although the report states that diagnostic accuracy can be considered a direct outcome, the rationale … The publication states that 14 of the 32 patients who received a biopsy had a previous negative biopsy … Groskopf/ Gen-Probe # 10 Table 12, p. 42 In the text on page 42 the AHRQ report states, “In two … The Nyberg publication states that at a PCA3 cut-off of 35 “the sensitivity was 66.7% and the specificity

455. Disposition of Comments for Efficacy and Safety of Screening for Postpartum Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
     May 01, 2013 - ES-16, l. 44-45 and Results p. 22 l. 55-57 and p. 57 l] 13 States 48% studies conducted in UK or Europe … When the USPSTF states the latter, screening and referral practices and reimbursement opportunities … In at least two places the team states that meta-analysis was not possible. … On page 14, under Timing, it states that prenatal screening was included. … For example, the TOC states Abbreviations can be found on page 73.

456. 15 Crosscutting Potential High Impact June 2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/15_crosscutting_potential_high_impact_june_2012.pdf
     January 01, 2012 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … Several versions of this model are being implemented in the United States, and we describe one of those … , and patient- logged events. 16 The IEMs, however, are not approved for marketing in the United States … increase patient satisfaction. 47 The first “Seniors Emergency Center” implemented in the United States

457. autism-update-protocol-130920 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_research-protocol.pdf
     September 20, 2013 - The prevalence of ASD in the United States is 11.3 cases per 1,000 (or 1 in 88) children living in the … total yearly societal per-capita cost of caring for and treating a person with autism in the United States … Prevalence of the Autism Spectrum Disorders (ASDs) in Multiple Areas of the United States, 2004 and … Available at http://www.cdc.gov/ncbddd/autism/states/ADDMCommunityReport2009.pdf. 6. … autism spectrum disorders—Autism and Developmental Disabilities Monitoring Network, 14 sites, United States

458. Disposition of Comments Report for Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions: An Update to the 2009 Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
     September 10, 2014 - Introduction The introduction clearly states the problems, and specifically indicates that the current … Introduction In the abstract, it states that "open biopsy continues to be considered the gold standard … 3) New "dense" notification laws have passed in at least 13 states, and others are being considered

459. S108 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s108.pdf
     October 01, 2007 - called agent-based mod- eling, a modeling technique in which individual entities are assigned internal states … Rules (or behaviors) are encoded to govern the transitions between states over time. … During the simulated hospital stay, individuals transitioned between 3 states: state 1—hospital- ized … Simulated patients moved from either of the hospitalized states to the discharged state.

460. Emergency Medical Service/911 Workforce Infection Control and Prevention Issues (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/ems-911-workforce-protocol.pdf
     January 01, 2015 - Timing • Published after 2006 and includes data after 2006 Setting • Conducted in the United States