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341. Progestogens-Preterm-Birth Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
     September 01, 2012 - are the leading cause of infant mortality and long-term disability.1-2 Each year in the United States … unsuccessful, with a 20 percent relative increase since 1990 in the proportion of births in the United States … relative to term infants, amounting to more than $8.6 billion of annual medical spending in the United States … Among maternal– fetal medicine specialists (MFMS) in the United States, prescribing increased from 38 … Two studies outside the United States found little use of progestogens—2 percent in Australia/New Zealand

342. Management of Suspected Opioid Overdose With Naloxone by Emergency Medical Services Personnel - Executive Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
     November 01, 2017 - four-fold.2,3 Drug overdose deaths are now the leading cause of injury-related death in the United States … dose of opioid involved in overdose, or involvement of other drugs or substances), setting (United States … Vital signs: overdoses of prescription opioid pain relievers—United States, 1999-2008. FIGURE 2. … Increases in drug and opioid overdose deaths—United States, 2010-2015. … Drug-poisoning deaths involving opioid analgesics: United States, 1999-2011. NCHS Data Brief 166.

343. Disposition of Comments Report for The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
     September 29, 2014 - Given all the attempts across states at public policy and laws regulating opioid use and prescribing … Accordingly the ES states: (p5) “Conclusions. … Indeed pES22 states: “Based on low-quality evidence regarding harms associated with long-term opioid … Quality of evidence The report states that relatively few studies met the inclusion criteria defined … “Vital Signs: Risk for Overdose From Methadone Used for Pain Relief-United States, 1999- 2010.

344. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
     January 01, 2012 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … take several months of tests before PAH is definitively diagnosed in a patient. 20 In the United States

345. Disposition of Comments for CER 182 Glasgow Coma Scale (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow-disposition-170415.pdf
     January 12, 2017 - The “Outcomes” section of the Methods states that for Key Question 4, we included outcomes that assessed … The Applicability section states: “The differences between the tGCS versus the mGCS or SMS in mean … The initial paragraph of the Discussion in the Executive Summary states: “Based on head-to- head studies … We do not feel that the Conclusion advocates for tGCS; it states: “The tGCS is associated with slightly … ability, as many would argue that tGCS is poorly and inconsistently applied by workers in different states

346. Minimal Modeling Approaches to Value of Information Analysis for Health Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
     June 01, 2011 - private-sector organizations in their efforts to improve the quality of health care in the United States … For example, systematic reviews of clinical topics, such as those performed by the United States (U.S … These models typically describe a series of health states, a mathematical model to describe transitions … among health states (e.g., a decision tree to describe the likelihood of events within periods and … Results of grey literature search, by country Country Search & Results United States We searched

347. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
     November 24, 2014 - Our introduction states that the target population is HAP which includes VAP and HCAP. … This approach is very consistent with the GRADE approach (used in both the United States and abroad) … great degree, we judge our approach to be the best available for reviews pertinent to the United States … penultimate paragraph (“First, the present PK/PD approaches do not directly…with IV antibiotics”) states

348. S16 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
     October 01, 2007 - Regulatory standards in the United States encourage placebo comparisons to isolate the effect of the … address comparisons relevant for policy makers.1 Such trials remain more common outside of the United States … feasible to conduct large research studies in community-based practice settings here in the United States … Similar audits of state-by-state performance indicated wide variation in complication rates between states … Variation and changes in state-specific carotid endarterectomy and 30-day mortality rates, United States

349. Particle Beam Radiation Therapies for Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/cancer-radiation/technical-brief
     September 14, 2009 - Currently, seven centers in the United States have facilities for particle (proton) irradiation, and

350. Single-arm studies in comparative effectiveness reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
     January 01, 2013 - private-sector organizations in their efforts to improve the quality of health care in the United States … detailed clinical data on all patients receiving implantable ventricular assist pumps in the United States … Secular trends in diabetes-related preventable hospitalizations in the United States, 1998-2006.

351. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/chronic-kidney-disease
     December 02, 2020 - Prevalence of multiple chronic conditions in the United States' Medicare population.

352. Disposition of Comments for CER 152 Nonmetastatic Muscle-Invasive Bladder Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-muscle-invasive_disposition-comments.pdf
     June 30, 2015 - The sentence in the Conclusion states, “extended lymph node dissection might be more effective than

353. Topic-Brief2-Opioid-Withdrawal (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief2-opioid-withdrawal.pdf
     April 01, 2021 - of Long-Term Opioid Analgesics4 • CDC Guideline for Prescribing Opioids for Chronic Pain – United States … Use of opioids and other analgesics by older adults in the United States, 1999-2010. … CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016. … Centers for Disease Control and Prevention data indicate 50 million adults in the United States have … Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016.

354. Disposition of Comments_Models of Care That Include Primary Care for Adult Survivors of Childhood Cancer: A Realist View (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/childhood-cancer-disposition-comments.pdf
     February 16, 2022 - It providers a concise summary of the literature and explicitly states the two aims of the realist … of childhood cancer with a focus on scalable models based on the COG guidelines across the United States … Specifically, the report states, “There is no consistent taxonomy for survivorship models of care, and

355. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - developed for technologies and programs that appear to be close to diffusion into practice in the United States … or for which some preliminary efficacy data in the target population are available) in the United States … a physical therapy protocol, as well as diet and hormone counseling as needed.6 The manufacturer states … that the new Regenexx procedure offered in the United States is compliant with Code of Federal Regulations … individual during the same surgical procedure.19,20 At least 22 medical facilities in the United States

356. Disposition of Comments for Technical Brief 29 Women Living With HIV-AIDS (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/women-hiv_disposition-comments.pdf
     November 21, 2016 - barriers self-defined by participants or is there some objective measure (e.g., what if a patient states … #2 (Laura Cheever) Findings This conclusion does not follow from the vignette, which explicitly states … limited availability of specific types of resources in the median and smallest cities in the six states … Diagnoses of HIV Infection in the United States and Dependent Areas, 2014. … HIV and AIDS in the United States by Geographic Distribution.

357. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - As the reviewer states there were no comparative studies, and in the absence of such studies conclusions … page 54, Table 6 states median/range of age not reported -- it was as mean and range We apologize … Peer Reviewer #5 Results page 60, table 8 states TTP and TTLP not reported, both are reported Based … As our conclusion states we believe the most important outcomes to be overall survival, QOL and adverse

358. Treatments for Fecal Incontinence | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/fecal-incontinence/research-protocol
     December 01, 2014 - newer, more invasive nonsurgical procedure. 11 Surgical procedures used to treat FI in the United States … conventional or modern treatments are FDA-approved (or seeking FDA-approval) for use in the United States … stages of clinical evaluation, others are used in Europe but are not approved for use in the United States … Interventions that do not require FDA approval and are used in the United States will be included. … for use in the United States.

359. C-Diff-Infections-Surveillance-140925 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
     January 01, 2014 - EIAs should no longer be the standard of care for detecting toxigenic C. difficile in the United States

360. Disposition of Comments: Comparative Effectiveness Review No. 237_Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-237-integrating-palliative-care-disposition-comments.pdf
     February 11, 2021 - family practice, professional organizations, policy organizations, and payors from across the United States … Many states department of health or similar websites(e.g., Kansas, Nebraska),that have legislatively … Public Reviewer #5 Appendices While the Methods section states that the review focused on serious