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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/food-insecurity-screening
July 28, 2022 - KQs 1, 4: Control group (can include historical control, active control/comparator) §
KQ 2: Any reference … standard
KQs 3, 5: No comparator required if explicitly addresses harms
KQs 1, 4: No control … /comparator
KQ 2: No reference standard
Outcomes
KQs 1, 4:
Food and nutrition security … trials, nonrandomized studies with less than 12-week followup
KQ 2: Test performance studies without reference … standard
KQs 3, 5: Case series, case reports, or editorials
Study quality
Fair to good
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
August 20, 2019 - standards; risk factors included in the models; and performance measures of the models. … Most studies used results of BRCA1/2 mutation testing as the reference standard, although 2 studies … Cancer Program Standards 2016. ACS website. … Relatives With Breast or Ovarian Cancer
Other Factors
Comparison With Other Models
Reference Standard … , 0.93
AUC, 0.71
Myriad II as reference standard (≥10% mutation probability): sensitivity,
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/food-insecurity-screening
March 11, 2025 - standard, potentially overstating the accuracy. … standard. … full reference standard (referred to as “embedded” administrations). … Quality: Study did not meet quality standards. … from the reference standard
Moderate (adequate for detection)
Eight of 10 studies conducted in or
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/yj6JY8HJZtbnv5qDPxS3PX
reported a
gender that
differs from their
sex
Screening instruments
compared with an
acceptable reference … standard (verified or
self-reported abuse or
validated screening
instrument for abuse)
Sensitivity … vulnerable
adults (age 18
years or older)
Eligible instruments
must be compared with
an acceptable reference … standard (verified or
self-reported abuse or
validated screening
instrument for abuse)
Sensitivity
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary17/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
December 15, 2013 - However, reference standards and study designs varied, and some models have been evaluated only in single … Practice standards for screening have preceded supporting evidence despite known harms of overscreening … Additional Risk Factors in Model
Accuracy Studies
Study, Year (Reference)
Population
Reference … Standard
Sensitivity, %
Specificity, %
PPV
NPV
FHAT
Clinical scoring tool; referral … Models Used as Reference Standards to Estimate Individual Risks for BRCA Mutations
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZgcL6cF6JsFzwRRhaSnqc9
December 01, 2022 - staff provided project oversight, reviewed the report to
ensure that the analysis met methodological standards
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/speech-and-language-delay-and-disorders-in-children-age-5-and-younger-screening-july-2015
July 07, 2015 - Included studies used well-regarded instruments used by speech-language pathologists as reference standards … ; however, individual studies used different reference standards.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/eko8Cp28pZ3SHHfyvTXJW5
May 13, 2025 - provided project oversight, reviewed the evidence review to ensure
that the analysis met methodological standards
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www.uspreventiveservicestaskforce.org/uspstf/document/screening-and-interventions-for-childhood-obesity-where-is-t/obesity-in-children-and-adolescents-screening-2005
July 11, 2005 - What are appropriate standards for overweight in childhood and what is prevalence of overweight based
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/cervical-cancer-screening-adults-adolescents
October 28, 2021 - assay or both; mode of collection or interval of testing
KQ 2:
Clinician-collected hrHPV sample
Reference … standard
No screening
Outcomes
KQ 1:
Precancerous lesions (i.e., CIN2+, CIN3+)
Invasive … Case series
Narrative reviews
Editorials
KQ 2:
Diagnostic test accuracy studies without a reference … standard
Setting
Primary care (e.g., internal medicine, family medicine, obstetrics/gynecology
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/3w8Wr9wwAyAqUJWmJo_bL-
February 01, 2014 - arising during the project; and review the final report
to ensure that it met basic methodological standards … However, reference standards and study designs var-
ied, and some models have been evaluated only in … risk for BRCA
mutations
8 studies of 5 models; no
studies of adverse effects
Diagnostic
accuracy
Reference … standards and study
designs varied; risk was
based on self-reported
information
Consistent High Good … Prac-
tice standards for screening have preceded supporting evi-
dence despite known harms of overscreening
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-screening-for-women-and-elderly-adults/intimate-partner-violence-and-elderly-abuse-screening-2004
March 08, 2004 - Study uses a credible reference standard, performed regardless of test results. … Reference standard interpreted independently of screening test. … standard; interprets reference standard independently of screening test; reliability of test assessed … Poor: Has important limitations such as: uses inappropriate reference standard; screening test improperly … administered; biased ascertainment of reference standard; small sample size of narrow selected spectrum
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/syphilis-infection-nonpregnant-adults-adolescents-screening
September 27, 2022 - staff provided project oversight, reviewed the report to ensure that the analysis met methodological standards
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/r_MgZHrtyHRn7rZoCPS6MT
February 01, 2011 - preschool
vision screening tests (Tables 6 and
7).27–58 Cycloplegic refraction was in-
cluded in the reference-standard … standard (ie, cy-
cloplegic refraction)
● Exclude studies that do not attempt
to perform the reference … standard, performed regardless of
test results
● Reference standard interpreted in-
dependently of … Standard
Reference Standard
Applied to All
Screened Patients
Same Reference
Standard
Applied to All … Patients
Reference Standard
and Screening
Examination
Interpreted
Independently
High Rate of
Uninterpretable
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/anxiety-adults-screening
August 27, 2020 - KQ 2 (Diagnostic accuracy):
Reference standard (structured or semistructured diagnostic interview … KQ 2: Maximum of 2 weeks between screening and reference standard.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/screening-depression-suicide-risk-adults
September 03, 2020 - KQ 2 (Diagnostic accuracy):
Reference standard (structured or semistructured diagnostic interview … KQ 2: Maximum of 2 weeks between screening and reference standard.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/unhealthy-alcohol-use-adolescents-adults-behavioral-counseling-interventions
February 01, 2024 - Pharmacotherapy
Comparators
KQs 1, 3: No screening or usual care KQ 2: Comparison with reference … standard (i.e., structured or semistructured clinical interview) KQs 4, 5:
No intervention
Usual
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary5/visual-impairment-in-children-ages-1-5-screening-2011
January 15, 2011 - standard (ie, cycloplegic refraction)
Exclude studies that do not attempt to perform the reference … standard, performed regardless of test results
Reference standard interpreted independently of screening … screening test; uses a credible reference standard; interprets reference standard independently of screening … standard; screening test improperly administered; biased ascertainment of reference standard; very small … Standard
Reference Standard Applied to All Screened Patients
Same Reference Standard Applied to
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/SvB6EjoVaaQxQr4vpCRtWp
March 01, 2004 - Vol 1-Standards. 1992. … • Study uses a credible reference standard,
performed regardless of test results. … • Reference standard interpreted independently of
screening test. … standard; interprets
reference standard independently of screening
test; reliability of test assessed … administered; biased ascertainment
of reference standard; small sample size of
narrow selected spectrum
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/5W2k4HLBPLPgHov6sSvuMH
July 24, 2018 - staff provided project oversight, reviewed the report to ensure that the
analysis met methodological standards