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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/clinical-pathway-methods-report.pdf
December 01, 2018 - AHRQ EPC report on the Early Diagnosis, Prevention, and
Treatment of Clostridium difficile in our standard … We found that the AHRQ EPC Report served as an evidence
standard and was particularly valuable given … In this respect, the EPC report served as an evidence
standard. … Our center has developed standard approaches to searching for pathways
(Appendix A). … Instead we present
a table listing the guidelines and how they are rated on each standard.
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effectivehealthcare-admin.ahrq.gov/products/c-diff-infections/research-protocol
December 01, 2019 - Standard antibiotics treatments: metronidazole, rifampicin, rifaxamin, vancomycin. … Timing:
Diagnostic testing: time to test
Antibiotic and non-standard treatments: variable, generally … Non-standard treatments from international settings will be included. … NOTE: The following protocol elements are standard procedures for all protocols. … Peer Review (Standard Languate)
Approximately five experts in the field will be asked to peer review
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-applicability/methods
December 01, 2019 - Comparator
Use of gold standard vs. “alloy” standard in studies. … Gold standard not applied.
Correlational data only. … Cardiac CT compared with stress treadmill without use of angiography as a gold standard. … Exclude a priori if no gold standard. … Failure to test “normals,” or subset, with gold standard.
Precision of estimates not provided.
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effectivehealthcare-admin.ahrq.gov/products/library-depression/white-paper
August 01, 2020 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
January 01, 2009 - The results of the test under evaluation are compared to those from a reference standard
in order to … or when the
new test is thought to be better than the current reference standard. … Strategies exist to deal with
cases in which the reference standard result is missing in some patients … or when information can
be used to build a substitute or proxy for the reference standard, but when … Evaluation of diagnostic tests when
there is no gold standard. A review of
methods.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
January 01, 2009 - The results of the test under evaluation are compared to those from a reference standard
in order to … or when the
new test is thought to be better than the current reference standard. … Strategies exist to deal with
cases in which the reference standard result is missing in some patients … or when information can
be used to build a substitute or proxy for the reference standard, but when … Evaluation of diagnostic tests when
there is no gold standard. A review of
methods.
-
effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-grading/methods
December 01, 2019 - Challenges: Diagnostic test evidence is challenging to grade because standard tools for grading evidence … One common challenge is that standard tools for assessing the quality of a body of evidence associated … It is possible that the accuracy of a test is better than the reference standard because of an imperfect … reference standard. … It is reasonable to consider either a more flexible qualitative approach to grading or the standard ordinal
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
April 01, 2012 - The approach to reviewing the identified potentially
eligible studies is standard and appears to have … Standard definitions
should be used that do not rely on the terminology used
in the manuscript. … Once again – the
problem of no gold standard / reference standard can
lead to biased results. … This was corrected and reference standard was defined
based on 5 criteria (IOP, visual field, optic … Data was reported in the abstract for
standard commercially available parameters using the
standard
-
effectivehealthcare-admin.ahrq.gov/products/ptsd-pharm-non-pharm-treatment-update/research
March 01, 2025 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/products/lumbar-spondylolisthesis/white-paper
March 01, 2021 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/products/c-diff-infections/research
December 01, 2019 - Review Methods
Standard Evidence-based Practice Center methods were employed. … For standard treatment, no antimicrobial is clearly superior for the initial cure of CDI.
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effectivehealthcare-admin.ahrq.gov/products/stem-cell-children/research
December 01, 2019 - Objectives
Assess comparative benefits and harms of hematopoietic stem-cell transplantation (HSCT) versus standard … therapy (both low strength)
Conclusions
Evidence demonstrating benefit or harm of HSCT versus standard
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effectivehealthcare-admin.ahrq.gov/products/asthma-nitric-oxide/research-protocol
June 01, 2021 - However, the diagnosis remains clinical; there is no single gold standard diagnostic test. … Comparators
KQ 1a: Standard diagnostic testing of asthma made by healthcare providers based on history … SABA, methacholine challenge Sputum eosinophils; Peripheral blood eosinophils; peak flow)
KQ 1b: Standard … qualitative research, in vivo, in vitro, and animal studies
Subgroups
Robustness of "gold standard … Meta-Analysis of Test Performance When There Is a "Gold Standard".
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - leading cause of cancer mortality worldwide.1
Breast conserving therapy has been widely adopted as standard … Compared with standard fractionation WBI, accelerated PBI was associated with
lower transportation costs … participated in clinical trials that led to the adoption of breast-conserving surgery
and WBI as a standard … Partial Breast
Irradiation Is the Preferred Standard of Care
for a Majority of Women With Early-Stage
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
March 01, 2012 - It would be standard practice to
spell out Clostridium the first time Clostridium difficile is used. … The designs of the studies have the probiotic
administered concurrently with the standard
antibiotic … REVISED TEXT; Cytotoxicity testing is not a
perfectly accurate gold standard. … Weren’t
there some papers that overlapped categories (e.g. comparing
standard and non-standard treatments … Subjects received the
probiotic along with a standard antibiotic.
-
effectivehealthcare-admin.ahrq.gov/products/machine-learning-tools/white-paper
December 01, 2024 - We included 56 studies, which evaluated the performance of tools primarily relative to standard human … screening tools (22 studies) had a median recall of 93 percent (range 1–100%) with human screening as the standard
-
effectivehealthcare-admin.ahrq.gov/products/cystic-fibrosis-hgh/research-protocol
December 01, 2019 - Height and weight z-scores (also called standard deviation scores or SDS) provide a relationship with … deviation or z-scores, height velocity, absolute values of weight, weight percentile, weight standard … deviation or z-scores, weight velocity, and weight for height standard deviation score. … Standard deviations (SDs) of the change scores will be calculated from the SD of the baseline values … NOTE: The following protocol elements are standard procedures for all protocols.
VIII.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
June 01, 2023 - or
method to detect the impact of
screening
KQ2: No reference standard to
determine the accuracy … • Reference standard: The domain will evaluate whether the reference standard, its
conduct, or its … interpretation may have introduced bias, taking into account the
quality of the reference standard … in correctly classifying the condition (e.g., a gold
standard may not exist) and whether the reference … standard results were
interpreted without knowledge of the results of the index test approach or tool
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/c-difficile-update_disposition-comments.pdf
March 29, 2016 - Thank you for this comment; we
attempted to present the bulleted
results in a standard fashion in … and not a consensus standard
that included clinical information. … A consensus reference
standard would be problematically
heterogeneous and make analysis
difficult … We have added more
discussion about how the
reference standard used strongly
influences the results … Commentator &
Affiliation Section Comment Response
Peer Reviewer #6 Discussion For the standard
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
March 15, 2016 - PhD,
on behalf of the
AACC
General
Comments
The traditional RCT is not necessarily the gold
standard … We have
included additional text in the
Discussion section stating
that studies including a
standard … compared to standard dose tacrolimus. … confined solely to studies comparing standard-to
reduced-dose CsA regimens.
5. … We also discuss trial
heterogeneity, and note the
lack of literature comparing
tacrolimus standard