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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
June 01, 2012 - Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard
Meta-analysis … Meta-analysis of test performance when there is a “gold standard.” … Meta-analysis of test performance when there is a “gold standard.” … Meta-analysis of test performance when there is a “gold standard.” … Gold Standard: A reference standard that is considered adequate in defining the presence or absence of
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effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-meta-analysis.ppt
June 01, 2012 - Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard
Meta-analysis … Meta-analysis of test performance when there is a “gold standard.” … Meta-analysis of test performance when there is a “gold standard.” … Meta-analysis of test performance when there is a “gold standard.” … Gold Standard: A reference standard that is considered adequate in defining the presence or absence of
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-performance/methods
December 01, 2019 - Diagnostic Accuracy, or the Case of the “Perfect” Reference Standard
A “perfect” reference standard … Parameterization when the reference standard is assumed “perfect” (“gold standard”)
Reference … Standard (+)
Reference Standard (-)
Index Test (+)
Index Test (-) … There is no “perfect” reference standard for OSA. … Identifying (Defining) the Reference Standard
One consideration is what reference standard is most
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - Recognize settings where the reference standard may be imperfect (i.e., no “gold standard”)
Describe … An “imperfect reference standard” is a reference standard test that misclassifies “true” status at a … lead to reference standard bias. … The “perfect” reference standard is the “gold standard.” … Imperfect Reference Standard Scenario (1 of 2)
The simplest example of an imperfect reference standard
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effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - Recognize settings where the reference standard may be imperfect (i.e., no “gold standard”)
Describe … An “imperfect reference standard” is a reference standard test that misclassifies “true” status at a … lead to reference standard bias. … The “perfect” reference standard is the “gold standard.” … Imperfect Reference Standard Scenario (1 of 2)
The simplest example of an imperfect reference standard
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-202-bronchial-thermoplasty-asthma.pdf
December 01, 2017 - Key Messages
• BT along with standard medical
management, compared to medical
management alone, may … • BT along with standard medical
management, compared to a similar
procedure without the heat (sham … • Evidence as to whether patients treated with BT and
standard care versus standard care alone experienced … than in the
standard care only group, the clinical importance of the
difference is unclear. … • •Patients treated with BT and standard care had fewer
emergency department (ED) visits compared
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effectivehealthcare-admin.ahrq.gov/products/asthma-nonpharmacologic-treatment/thermoplasty-systematic-review
October 01, 2019 - Key Messages
BT along with standard medical management, compared to medical management alone, may … BT and standard care improved asthma control (defined by the Asthma Control Questionnaire [ACQ] change … from baseline to 12 months) and Asthma Quality of Life Questionnaire (AQLQ) scores more than standard … However, BT and standard care, compared with a sham bronchoscopic procedure and standard care, did not … In the RCTs comparing BT and standard care to standard care alone, evidence was insufficient to assess
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-performance/slides
December 01, 2019 - Reports
Options for Summarizing Medical Test Performance in the Absence of a Gold Standard … Options for Summarizing Medical Test Performance in the Absence of a Gold Standard … Project Timeline
Options for Summarizing Medical Test Performance in the Absence of a "Gold Standard … Presentation:
Options for Summarizing Medical Test Performance in the Absence of a Gold Standard
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-metaanalysis/slides
December 01, 2019 - Evidence Reports
Meta-analysis of Test Performance Evidence When There is a “Gold Standard … Meta-analysis of Test Performance Evidence When There is a “Gold Standard … Project Timeline
Meta-Analysis of Test Performance When There Is a "Gold Standard"
Nov 4, 2010 … Presentation:
Meta-analysis of Test Performance Evidence When There is a “Gold Standard
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-bias/methods
December 01, 2019 - Reference Standard and Verification Procedure
Inappropriate reference standard
Errors of imperfect … Risk: Low/High/Unclear
Domain 3: Reference Standard
Is the reference standard likely to correctly … (Yes/No/Unclear)
Did all patients receive a reference standard? … (Yes/No/Unclear)
Did all patients receive the same reference standard? … NO: Not all relatives receive verification via the reference standard.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
July 01, 2012 - Diagnostic Accuracy, or the Case of the “Perfect” Reference Standard
A “perfect” reference standard … Parameterization when the reference standard is assumed “perfect” (“gold standard”)
Reference Standard … reference standard is a perfect reflection of the truth. … There is no “perfect” reference standard for
9-9
OSA. … Identifying (Defining) the Reference Standard
One consideration is what reference standard is most
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rapid-review-no-touch-modalities.pdf
May 01, 2022 - Another pre/post study15 compared UVL + standard cleaning (bleach) to standard cleaning
and found no … *Standard cleaning
protocol not explicitly
described. … % of rooms contaminated with
CD:
• Before standard cleaning:
31.8% (7/22)
• After standard cleaning … Phase II: (24 rooms)
Standard terminal
cleaning* vs. … Standard
cleaning + Solid Copper Surfaces +
Copper Linens
*Standard cleaning involved
quaternary
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effectivehealthcare-admin.ahrq.gov/products/heart-disease-ace-inhibitor-arb/research
December 01, 2019 - Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard
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effectivehealthcare-admin.ahrq.gov/products/heart-disease-ace-inhibitor-arb-future/research
March 01, 2020 - Research Needs for Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Research Needs for Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Research Needs for Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard … Research Needs for Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard
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effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/graphical-augmentations-abstract
June 01, 2024 - Most funnel plots present treatment effects against their standard errors, and the contours depicting … However, treatment effects and their standard errors are frequently associated even if no publication … bias exists (eg, both variables depend on the four data cells in a 2 × 2 table for the odds ratio), so standard-error-based … missingness of studies may relate to their sample sizes besides P values (which are partly determined by standard … However, the contours for standard-error-based funnel plots cannot be directly applied to sample-size-based
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
July 01, 2012 - Reference Standard and Verification Procedure
Inappropriate reference
standard
Errors of imperfect … Risk: Low/High/Unclear
Domain 3: Reference Standard
Is the reference standard likely to correctly … (Yes/No/Unclear)
Did all patients receive a reference standard? … (Yes/No/Unclear)
Did all patients receive the same reference standard? … NO: Not all relatives receive verification via the reference standard.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/skin-substitute_0.pdf
October 03, 2019 - Are there some basic treatments that should constitute standard of care for specific ulcer
types (e.g … of care
Standard of care plus synthetic dressings,
growth factors, skin grafts
Other acceptable … of care Studies not administering similar standard
of care or not describing standard of care
Study … treatments used as a
comparison
Other skin substitute
product
Standard of care
Standard of care … treatments used as a
comparison
Other skin substitute
product
Standard of care
Standard of care
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer18-heart-disease-ace-inhibitor-arb-executive.pdf
October 01, 2009 - medical therapy when compared to
standard medical therapy alone? … medical therapy when compared to
standard medical therapy alone? … . standard medical
therapy alone (with or without a placebo). … medical
therapy when compared to standard medical therapy alone? … medical therapy when compared to standard medical therapy alone?
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effectivehealthcare-admin.ahrq.gov/products/skin-substitutes/protocol
January 01, 2020 - Are there some basic treatments that should constitute standard of care for specific ulcer types (e.g … of care
Standard of care plus synthetic dressings, growth factors, skin grafts
Other acceptable … of care
Studies not administering similar standard of care or not describing standard of care … treatments used as a comparison
Other skin substitute product
Standard of care
Standard of … treatments used as a comparison
Other skin substitute product Standard of care Standard of care
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
February 01, 2018 - ► SMD is computed as the mean effect divided by a pooled estimate of the
standard error, putting … all estimates on the same scale (i.e., standard
deviations) … Where:
mT = mean of treatment group
mC = mean of control group
Spooled = pooled standard error
5. … • The correlation between the two study arms must be considered
when computing standard errors.5
► … Generally the correlation is positive, resulting in smaller SEs than in a
standard parallel trial.