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  1. www.uspreventiveservicestaskforce.org/home/getfilebytoken/GGtWkLmFWWpqzVAVHsjNCh
    June 01, 2016 - • In the next stage, or secondary syphilis, a person can develop skin rashes, sore throat, swollen … • Late stage syphilis can develop in about 15% of people who have not been treated. … In this stage, the disease can damage the brain, nerves, eyes, heart, blood vessels, liver, bones, and … Syphilis can damage the nervous system at any stage of the disease, causing symptoms such as headaches … Once identified, syphilis can be treated with an antibiotic, usually penicillin, and cured at any stage
  2. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/lung-cancer-screening
    August 16, 2018 - on treatment will be limited to studies of surgical resection or stereotactic body radiotherapy for stage … LDCT) change the incidence of lung cancer and the distribution of lung cancer types and stages (i.e., stage … specified change in lung cancer incidence (and change in distribution of lung cancer stages [i.e., stage … KQs 1–5, 8: Asymptomatic adults (age ≥18 years) KQs 6, 7: Adults (age ≥18 years) with early (stage … shift (where more cancer cases are detected at an earlier stage).
  3. www.uspreventiveservicestaskforce.org/uspstf/recommendation/testicular-cancer-screening-1996
    January 01, 1996 - If sensitivity is defined as the probability that disease, when present, is detected at a curable stage … The current 5-year survival for Stage I seminoma treated with radiotherapy is 97%. 3 Stage I nonseminomatous … Even without screening, 60-80% of seminomas are Stage I at diagnosis. 17 There is evidence that once … Impact of delay in diagnosis on clinical stage of testicular cancer. … Clinical stage I carcinoma of the testis: a review. J Clin Oncol . 1988;6:734–750. [ PubMed ] 18.
  4. www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-1996
    January 01, 1996 - Survival appears to be longer for persons with early-stage disease 5-year survival is 87% for Stage A … (nonpalpable) tumors, 81% for Stage B (palpable, organ-confined cancer), 64% for Stage C (local extracapsular … is now increasingly diagnosed at a less advanced stage. … Stage C and Stage D disease are often incurable, and the efficacy of treatment for Stage B prostate cancer … Expectant management of early stage prostatic cancer: Swedish experience.
  5. www.uspreventiveservicestaskforce.org/uspstf/procedure-manual/procedure-manual-appendix-xiii-template-scoping-decision-problem-address-through-decision-modeling
    July 01, 2017 - horizon to capture relevant differences across strategies (this may or may not be critical at the scoping stage … determine net impact, such as diagnostic/treatment burden (these may or may not be critical at the scoping stage … intended audience, and original development purpose (these may or may not be critical at the scoping stage
  6. www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-appendix-xiii-template-scoping-decision-problem-address-through-decision-modeling
    July 01, 2017 - horizon to capture relevant differences across strategies (this may or may not be critical at the scoping stage … determine net impact, such as diagnostic/treatment burden (these may or may not be critical at the scoping stage … intended audience, and original development purpose (these may or may not be critical at the scoping stage
  7. www.uspreventiveservicestaskforce.org/home/getfilebytoken/HyUp34oAxpbu93xhA4n-Y7
    March 29, 2011 - consists of orchiectomy and may include other surgery, radiation therapy, or chemotherapy, depending on stage … Regardless of disease stage, over 90% of all newly diagnosed cases of testicular cancer will be cured
  8. www.uspreventiveservicestaskforce.org/uspstf/recommendation/skin-cancer-screening
    April 18, 2023 - disease to 31.9% for distant-stage disease. 11 Because keratinocyte carcinoma is common and usually … Results showed that there is a strong, consistent positive association between more advanced stage at … , 31.5 (95% CI, 28.9-34.2) for regional stage, and 169.6 (95% CI, 154.2-186.6) for distant stage. … , 3.9 (95% CI, 3.8-4.1) for regional stage, and 15.8 (95% CI, 14.9-16.7) for distant stage, compared … No evidence was available assessing the association between stage at keratinocyte carcinoma detection
  9. www.uspreventiveservicestaskforce.org/home/getfilebytoken/zWWcTu328Y27Uu4mPt6ZVF
    August 01, 2022 - and surrounding normal tissue and possibly taking a biopsy of the sentinel lymph node to determine stage … Results showed that there is a strong, consistent positive association between more advanced stage at … , 31.5 (95% CI, 28.9- 34.2) for regional stage, and 169.6 (95% CI, 154.2-186.6) for distant stage. … , 3.9 (95% CI, 3.8-4.1) for regional stage, and 15.8 (95% CI, 14.9-16.7) for distant stage, com- pared … No evidence was available assessing the association between stage at keratinocyte carcinoma detection
  10. www.uspreventiveservicestaskforce.org/home/getfilebytoken/hAtvvyktSrBv8au38g7HnP
    May 08, 2017 - including radioactive iodine therapy, may be indicated, depending on postoperative disease status, tumor stage … External-beam radiation therapy and chemotherapy are not generally used to treat early-stage, differentiated
  11. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/breast-cancer-screening-adults
    May 06, 2021 - subjective well-being Breast cancer mortality All-cause mortality KQ 2: Detection and stage … distribution of screen-detected invasive breast cancer Detection of advanced cancer and stage distribution … standardized and available outcomes will likely vary across studies (e.g., metastatic breast cancer, different stage … possible we will report outcomes for cancers diagnosed at American Joint Committee on Cancer (AJCC) stage
  12. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/breast-cancer-screening
    May 06, 2021 - subjective well-being Breast cancer mortality All-cause mortality KQ 2: Detection and stage … distribution of screen-detected invasive breast cancer Detection of advanced cancer and stage distribution … standardized and available outcomes will likely vary across studies (e.g., metastatic breast cancer, different stage … possible we will report outcomes for cancers diagnosed at American Joint Committee on Cancer (AJCC) stage
  13. www.uspreventiveservicestaskforce.org/home/getfilebytoken/CPCr9xB4m5UcxxoN_WuUQt
    August 01, 2019 - Of these pancreatic adenocarcinoma cases, three were detected at stage I, one was stage IIA, three were … stage IIB, three were metastatic, and one was reported as resectable with no stage given. … Of these pancreatic adenocarcinoma cases, two were detected at stage IA, two were stage IIA, one was … with no stage given. … Associations of Socioeconomic Variables With Resection, Stage, and Survival in Patients With Early-Stage
  14. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-report/lung-cancer-screening
    July 30, 2013 - Model F estimates cure rates that depend on sex, tumor stage, and histology. … Model M assumes that most patients with early-stage lung cancer would undergo resection and that (for … Mortality reduction due to screening is due to the earlier stage and younger age at detection. … Advanced-stage lung cancer is, by definition, detected after the onset of lethal metastases, but some … early-stage cases are detected before this occurs.
  15. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-report/lung-cancer-screening-december-2013
    July 30, 2013 - Model F estimates cure rates that depend on sex, tumor stage, and histology. … Model M assumes that most patients with early-stage lung cancer would undergo resection and that (for … Mortality reduction due to screening is due to the earlier stage and younger age at detection. … Advanced-stage lung cancer is, by definition, detected after the onset of lethal metastases, but some … early-stage cases are detected before this occurs.
  16. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-screening-for-breast-cancer/breast-cancer-screening-january-2016
    January 11, 2016 - For advanced cancer outcomes, studies that reported the incidence of late-stage disease among screened … Studies provided heterogeneous measures of breast cancer severity and generally reported early-stage … Biennial versus annual mammography and the risk of late-stage breast cancer. … II–IV; III or IV Stage II–IV: 39% (41/105) vs. 52% (74/142); P =0.06 Stage III or IV: 4% (n … IIB or greater Adjusted proportion of cancer stage for 2-year vs 1-year intervals Stage III or
  17. www.uspreventiveservicestaskforce.org/Home/GetFile/1/17045/pancreatic-cancer-screening-final-evidence-review/pdf
    August 01, 2019 - Of these pancreatic adenocarcinoma cases, three were detected at stage I, one was stage IIA, three were … stage IIB, three were metastatic, and one was reported as resectable with no stage given. … Of these pancreatic adenocarcinoma cases, two were detected at stage IA, two were stage IIA, one was … with no stage given. … Associations of Socioeconomic Variables With Resection, Stage, and Survival in Patients With Early-Stage
  18. www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/lung-cancer-screening1
    May 03, 2018 - evidence on treatment in the systematic review will be limited to studies of surgical resection of stage … How effective is surgical resection for the treatment of early (stage I) non-small cell lung cancer? … What are the harms associated with surgical resection of early (stage I) non-small cell lung cancer? … Populations KQs 1–5, 8: Asymptomatic adults (age ≥18 years) KQs 6, 7: Adults (age ≥18 years) with early (stage … diagnosis of lung cancer KQs 6, 7: Children; persons with nonprimary lung cancer or other than stage
  19. www.uspreventiveservicestaskforce.org/uspstf/document/evaluating-test-strategies-for-colorectal-cancer-screening-a-decision-analysis-for-the-us-preventive-services-task-force/colorectal-cancer-screening-2008
    October 15, 2008 - The cancer then eventually progresses from stage I (localized) to stage IV (distant metastasis). … stage III," and "Preclinical stage IV." … distribution of CRC cases Stage I 16.6 21.1 19.3 24.0 21.9 19.4 Stage II 23.0 … 28.3 31.4 39.6 35.1 34.8 Stage III 33.7 26.3 26.1 20.0 22.2 22.6 Stage … 1, and finally enters the clinical cancer stage 1.
  20. www.uspreventiveservicestaskforce.org/home/getfilebytoken/UPu84CV2CNuxR8kpVU6e3V
    November 01, 2008 - I Preclinical Cancer States Preclinical stage II Preclinical stage III Preclinical stage IV Clinical … stage I Clinical Cancer States Clinical stage II Clinical stage III Clinical stage IV The opportunity … distribution of CRC cases Stage I 16.6 21.1 19.3 24.0 21.9 19.4 Stage II 23.0 28.3 31.4 39.6 35.1 34.8 … Stage III 33.7 26.3 26.1 20.0 22.2 22.6 Stage IV 26.7 24.4 23.2 16.4 20.7 23.2 CRC � colorectal cancer … The cancer then eventually progresses from stage I (localized) to stage IV (distant metastasis).

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