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effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
January 01, 2011 - Systematic Review Protocol
Project Title: Laboratory biomarkers for iron deficiency anemia in late stage … CKD patients
are classified into five stages depending on the severity of the condition (CKD stage … When
CKD progresses to its end stage, it would necessitate dialysis or kidney transplantation. … Definitions of CKD stages 1–5:
o CKD stage 1: a glomerular filtration rate (GFR) >90 ml/min, with … The impact of anemia on cardiomyopathy, morbidity, and
mortality in end-stage renal disease.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
July 24, 2013 - all individuals with other
causes for cirrhosis (including alcoholic cirrhosis), and patients with stage … imaging techniques are available to
identify the presence of lesions, diagnose HCC, and determine the stage … There is clinical uncertainty about which imaging technique to use to diagnose and stage
HCC. … What is the comparative test performance of imaging techniques to predict HCC tumor
stage?
i. … Outcomes Diagnostic outcomes include:
• Measures for accuracy of staging (stage reclassification).
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effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
October 01, 2007 - This approach is referred to as anamorphic design26 or
2-stage design.27,28 The data can then be analyzed … If confounding by the additional
covariates is detected in stage 2, however, the estimates from
stages … Logistic regression analysis and efficient design
for two-stage studies. … Analytic methods for two-stage case-control
studies and other stratified designs. … Designs and analysis of two-stage studies. Stat Med.
1992;11:769–782.
30. Langholz B, Clayton D.
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effectivehealthcare.ahrq.gov/products/colon-cancer-gene-profiling/research-protocol
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/advanced-care-decision-aids_disposition-comments.pdf
July 29, 2014 - Framework: ACP (and thus tools for
ACP) vary by the target group’s stage of life and health. … These are real decisions for person in stage 1 of ACP
(healthy) and they are appropriately not focused … In stage one (healthy), a key index decision is “Who will
be my surrogate if one should be needed?” … For someone in stage three (advanced stage of
serious illness), a proxy decision is still critical if … At what stage of disease? Should the doctor
be allowed to initiate this discussion?
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_executive.pdf
August 01, 2012 - progresses
Second Stage
• Begins when cervix is
completely dilated (10 cm) and
ends with the birth … partially or fully block voluntary
motor control in lower half of body
• Initiated during first stage … of labor with
infusion usually continuing into second
stage
• May be continued into third stage if … pethidine, morphine,
fentanyl, remifentanil, butorphanol, and
nalbuphine
• Used during the first stage … the United States because
it causes fetal bradycardia (slow heart
rate)
• Used during the first stage
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
November 02, 2018 - age, sex, race/ethnicity, education, depression, pre-treatment cognitive or
functional level/CATD stage … Reasons for exclusion at this stage will be reported. … Based on the frequency with which they are reported, we will decide
which specific stage, cognitive … than at CATD stage, so that recognizing CATD currently is a higher
priority than recognizing MCI. … Specified that we would
determine which validated
stage, cognitive,
functional, quality of life,
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0495_05-24-2013.pdf
January 01, 2013 - Staff-Generated PICO
Population(s): Metastatic breast cancer patients (stage IV)
Intervention(s): Imaging … )
Metastatic or advanced breast cancer, defined as stage IV cancer, involves the spread of cancer
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
May 01, 2013 - to
differentiate between patients with BCLC stage A and
B liver disease across publications. … • No studies presented subgroup analyses on age, sex,
disease etiology, or HCC stage. … RFA to PEI/PAI: HCC stage Insufficient None of the 3 RCTs reported subgroup analysis by HCC
stage (e.g … ., BCLC stage A or B). … BCLC stage B)
and to compare studies of equivalent patient populations.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-function_research-protocol.pdf
June 13, 2013 - Stage of kidney disease (CKD stages I-IV or ESRD on dialysis)
e. Status post renal transplant
f. … Stage of kidney disease (CKD stages I-IV or ESRD on dialysis)
e. Status post renal transplant
f. … Stage of kidney disease (CKD stages I-IV or ESRD on dialysis)
e. Status post renal transplant
f. … Use of cardiac biomarkers in end-stage renal disease. J Am Soc
Nephrol. 2008 Sep;19(9):1643-52. … Plasma elimination of cardiac troponin I in end-
stage renal disease.
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research-protocol
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effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
July 21, 2014 - wall and adjacent structures.5 Bladder cancers that have not invaded the bladder
smooth muscle layer (stage … Stage 2 cancers are
muscle-invasive, and higher stage cancers invade beyond the muscle layer into
surrounding … fat (stage classification T3 bladder cancer) or beyond the fat into nearby
organs or structures (stage … Prognosis is poorer for patients with more invasive Stage 2 or higher bladder cancers (5-
year survival … These include the stage of the cancer, tumor grade, whether the tumor
is an initial tumor or a recurrence
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
December 01, 2014 - grouping)
to determine the overall stage, commonly reported as stage
I, IIA, IIB, III, or IV, with … stage I being the least advanced
and stage IV being the most advanced. … or less, a Gleason score of 6 or less, and clinical
stage T1c or T2a
• Intermediate risk (roughly … clinical stage T2b but not qualifying for
high risk
• High risk (roughly corresponding to stage IIB … However, the tumor stage differed in these trials.
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effectivehealthcare.ahrq.gov/products/renal-disease-therapies/abstract
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
April 18, 2017 - nutrient requirement of
nearly all healthy individuals” (97.5 percent) in a particular age and sex (life stage … thought to meet or exceed the nutrient
requirements of almost all individuals in a particular life stage … inclusion in the review,
with the exception of studies exclusively reporting on patients with end
stage … Studies
exclusively reporting on patients with end stage renal disease, heart failure,
HIV, or cancer … A two-stage hierarchical regression model for meta-analysis
of epidemiologic nonlinear dose–response
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
October 01, 2014 - all individuals
with other causes for cirrhosis (including
alcoholic cirrhosis), and patients with stage … are available to detect
the presence of lesions, evaluate focal liver lesions, and
determine the stage … What is the comparative test performance of imaging
techniques to predict HCC tumor stage?
i.
-
effectivehealthcare.ahrq.gov/sites/default/files/diverticulitis-nomination-extra.pdf
May 29, 2025 - Management of Acute Diverticulitis Additional Information for Topic Nomination
Table 1. Key Questions and PICOTS
KQ1: Antibiotics KQ1: Antibiotics vs.
No Antibiotics
KQ2: Diagnostic
imaging
KQ3: Follow-up
colonoscopy
KQ4: Surgical and
interventional
management
KQ5: Prevention of
recurrence
Populat…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
November 28, 2012 - for
patients with a single lesion, regardless of its size.8
Disease Classification
Both tumor stage … treatment algorithms in
Europe and North America.7 It takes into account factors related to tumor stage … Another scoring system for chronic liver disease is the Model for End-Stage Liver Disease
(MELD) score … addition, the use of various disease classification systems and the inability to translate
disease stage … Surgical resection versus percutaneous thermal
ablation for early-stage hepatocellular carcinoma: a
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effectivehealthcare.ahrq.gov/products/colon-cancer-gene-profiling/technical-brief