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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
    January 01, 2011 - Systematic Review Protocol Project Title: Laboratory biomarkers for iron deficiency anemia in late stage … CKD patients are classified into five stages depending on the severity of the condition (CKD stage … When CKD progresses to its end stage, it would necessitate dialysis or kidney transplantation. … Definitions of CKD stages 1–5: o CKD stage 1: a glomerular filtration rate (GFR) >90 ml/min, with … The impact of anemia on cardiomyopathy, morbidity, and mortality in end-stage renal disease.
  2. effectivehealthcare.ahrq.gov/health-topics/skin-conditions
    December 08, 2017 - Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin Systematic Review December 8, 2017 Technical Brief: Evaluation of Suspicious Skin Lesions Using Non-Invasive Diagnostic Techniques Research Protocol Archived August 23, 2010 Systematic Review of Treatments f…
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
    October 01, 2012 - 5 experts thought this conclusion was still valid. 1 cited a study21 stating separate data on CKD stage … Congestive Heart Failure; CKD=Chronic Kidney Disease; eGFR=Epidermal growth factor receptor; ESRD=End-Stage … fruits and vegetables OR oral sodium bicarb OR no intervention 27 Hypertensive nephropathy at stage … 1 or 2 eGFR Indices of kidney injury 30 days Indices of kidney injury were not changed in Stage 1 … However, stage 2 patients decreased urinary albumin, N-acetyl B-D- glucosaminidase and transforming
  4. S158 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
    October 01, 2007 - This approach is referred to as anamorphic design26 or 2-stage design.27,28 The data can then be analyzed … If confounding by the additional covariates is detected in stage 2, however, the estimates from stages … Logistic regression analysis and efficient design for two-stage studies. … Analytic methods for two-stage case-control studies and other stratified designs. … Designs and analysis of two-stage studies. Stat Med. 1992;11:769–782. 30. Langholz B, Clayton D.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
    May 01, 2013 - to differentiate between patients with BCLC stage A and B liver disease across publications. … • No studies presented subgroup analyses on age, sex, disease etiology, or HCC stage. … RFA to PEI/PAI: HCC stage Insufficient None of the 3 RCTs reported subgroup analysis by HCC stage (e.g … ., BCLC stage A or B). … BCLC stage B) and to compare studies of equivalent patient populations.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0495_05-24-2013.pdf
    January 01, 2013 - Staff-Generated PICO Population(s): Metastatic breast cancer patients (stage IV) Intervention(s): Imaging … )  Metastatic or advanced breast cancer, defined as stage IV cancer, involves the spread of cancer
  7. effectivehealthcare.ahrq.gov/products/chronic-kidney-disease-anemia-2011/research
    October 12, 2012 - Disposition of Comments Report Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage … We considered studies of pediatric and adult nondialysis patients with stage 3, 4, or 5 CKD, patients
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - all individuals with other causes for cirrhosis (including alcoholic cirrhosis), and patients with stage … are available to detect the presence of lesions, evaluate focal liver lesions, and determine the stage … What is the comparative test performance of imaging techniques to predict HCC tumor stage? i.
  9. effectivehealthcare.ahrq.gov/products/bladder-cancer-non-muscle-invasive/research-protocol
    July 21, 2014 - and adjacent structures. 5 Bladder cancers that have not invaded the bladder smooth muscle layer (stageStage 2 cancers are muscle-invasive, and higher stage cancers invade beyond the muscle layer into surrounding … fat (stage classification T3 bladder cancer) or beyond the fat into nearby organs or structures (stage … Prognosis is poorer for patients with more invasive Stage 2 or higher bladder cancers (5-year survival … Does the comparative effectiveness differ according to tumor characteristics, such as histology, stage
  10. effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies/protocol
    September 12, 2019 - Surveillance, Epidemiology, and End Results Program SUO= Society of Urological Oncology T1= tumor Stage … 1 T2= tumor Stage 2 T3= tumor Stage 3 T4= tumor Stage 4 WMD= weighted mean differences WW= … , device trade name, keyword, floating subheading word, candidate term word] (526) 13     10 and (stage … 1 or stage one).mp. … trade name, keyword, floating subheading word, candidate term word] (16) 14     10 and (early adj3 stage
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_executive.pdf
    August 01, 2012 - progresses Second Stage • Begins when cervix is completely dilated (10 cm) and ends with the birth … partially or fully block voluntary motor control in lower half of body • Initiated during first stage … of labor with infusion usually continuing into second stage • May be continued into third stage if … pethidine, morphine, fentanyl, remifentanil, butorphanol, and nalbuphine • Used during the first stage … the United States because it causes fetal bradycardia (slow heart rate) • Used during the first stage
  12. effectivehealthcare.ahrq.gov/products/undescended-testicle/research
    December 11, 2012 - Weighted averages of success were 78.7 percent for one-stage Fowler-Stephens, 86 percent for two-stage
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-muscle-invasive_research-protocol.pdf
    July 21, 2014 - Stage 2 cancers are muscle-invasive, and higher stage cancers invade beyond the muscle layer into surrounding … fat (stage classification T3 bladder cancer). … Stage T4a cancers, which go beyond the fat into the prostate, vaginal wall, or uterus, are also still … Stage T4b cancer, in which the tumor has spread to the pelvis or abdominal wall, bladder cancer involving … Approximately 25 percent of newly diagnosed bladder cancers present as stage 2 or higher tumors.6 Once
  14. effectivehealthcare.ahrq.gov/products/anal-cancer-treatment/protocol
  15. effectivehealthcare.ahrq.gov/get-involved/nominated-topics/diagnosis-and-treatment-of-non-muscle-invasive-bladder-cancer
    October 03, 2012 - How do tumor characteristics (stage, grade, multiplicity, size, molecular and genetic alterations) predict … (For example, an ethnic group, stage or severity of a disease.) … aggressive form of malignancy, and when diagnosed, bladder cancer may manifest itself at a more advanced stage … also consistently worse for African Americans than for any other ethnicity, even when stratified by stage … Without a post-treatment strategy in place, recurrence and progression into a muscle-invasive stage is
  16. effectivehealthcare.ahrq.gov/products/liver-cancer-therapy/research-protocol
    March 20, 2012 - for patients with a single lesion, regardless of its size. 8 Disease Classification Both tumor stage … treatment algorithms in Europe and North America. 7 It takes into account factors related to tumor stage … Another scoring system for chronic liver disease is the Model for End-Stage Liver Disease (MELD) score … addition, the use of various disease classification systems and the inability to translate disease stage … In 1999 the BCLC staging system was published which links the stage of disease to specific treatment
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
    November 28, 2012 - for patients with a single lesion, regardless of its size.8 Disease Classification Both tumor stage … treatment algorithms in Europe and North America.7 It takes into account factors related to tumor stage … Another scoring system for chronic liver disease is the Model for End-Stage Liver Disease (MELD) score … addition, the use of various disease classification systems and the inability to translate disease stage … Surgical resection versus percutaneous thermal ablation for early-stage hepatocellular carcinoma: a
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
    December 01, 2014 - grouping) to determine the overall stage, commonly reported as stage I, IIA, IIB, III, or IV, with … stage I being the least advanced and stage IV being the most advanced. … or less, a Gleason score of 6 or less, and clinical stage T1c or T2a • Intermediate risk (roughly … clinical stage T2b but not qualifying for high risk • High risk (roughly corresponding to stage IIB … However, the tumor stage differed in these trials.
  19. effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
    March 01, 2017 - nutrient requirement of nearly all healthy individuals" (97.5 percent) in a particular age and sex (life stage … thought to meet or exceed the nutrient requirements of almost all individuals in a particular life stage … to the clinical outcome of interest, as well as studies exclusively reporting on patients with end stage … Studies exclusively reporting on patients with end stage renal disease, heart failure, HIV, or cancer … A two-stage hierarchical regression model for meta-analysis of epidemiologic nonlinear dose–response
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancer-key-questions.pdf
    January 01, 2020 - KQ2: Does treatment effectiveness vary by cancer variables (stage, histology, biomarkers status at diagnosis … gastric cancer Recurrent cancer, metastatic cancer, those in hospice or receiving palliative care, Stage

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