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2061. FRN 41 - Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis-future_research_1.pdf
      February 01, 2013 - Further reproduction of those copyrighted materials is prohibited without the specific permission of … The ECHO and SPECT modalities, although less sensitive, appeared to be more specific in women. … The ECHO and SPECT modalities, although less sensitive, appeared to be more specific in women. … • There were insufficient data to demonstrate that the use of specific NITs (compared with coronary … What is the value of performing a specific NIT test for the diagnosis of CAD in women, compared with

2062. Layout 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_executive.pdf
      February 01, 2006 - Layout 1 Background Breast cancer is the second most common malignancy in women. The American Cancer Society estimated that in the United States in 2005, 212,930 women would be newly diagnosed as having breast cancer and there would be 40,870 deaths due to this disease. Because early breast cancer is asymptomatic, th…

2063. Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Comparative Effectiveness Review | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies-update/research-protocol
      March 29, 2013 - These presenting symptoms along with a physical examination, prostate-specific antigen (PSA) levels, … The cancer is identified by needle biopsy, which is performed because of high prostate-specific antigen … Details (specific search terms and search strategies) are provided in Appendix A of this protocol. … Prostate-Specific Antigen Best Practice Statement: 2009 Update. … They are selected to provide broad expertise and perspectives specific to the topic under development

2064. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
      March 01, 2012 - Specific reference to the use of embolic protection devices in saphenous vein grafts has been added … E.g. specific outcomes in rows, covariates in columns and available evidence (pooled or otherwise) in … We have organized the report according to the specific population (STEMI vs. other ACS) for several … There are references to specific device names that were used in specific trials, which was commonly … done in the event there was only one trial evaluating the specific outcome/comparison.

2065. Research Protocol (Amended): Treatment of Acute Pain--An Evidence Map (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
      June 10, 2018 - Many unidimensional and multidimensional pain assessment scales are available including specific scales … for a variety of pain conditions10-13 and for specific sub- populations.14-17 Multidimensional assessment … We will construct search strategies to identify original research on specific acute pain conditions … Information Management Evidence tables specific to each priority acute pain condition will be created … • Are you aware of clinical practice guidelines addressing specific common acute pain conditions?

2066. Radiotherapy-Proton-Beam Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiotherapy-proton-beam_research.pdf
      May 01, 2012 - proton beam radiotherapy has gained acceptance based on a theo- retical advantage for the treatment of specific … CMS has yet to issue a national coverage rule for proton beam therapy or its specific indications. … proton beam radiotherapy along with external beam radiotherapy in general but without identifying specific … one of the LCDs. *** These indications appear in the claims but are not covered in the LCDs listing specific … DISCUSSION As a highly specific form of advanced radiotherapy, proton beam therapy may play an important

2067. Transparency of Reporting Requirements: Tympanostomy Tubes (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
      September 02, 2016 - spur pediatric research, children remain “therapeutic orphans” 12 for whom a paucity of pediatric-specific … Appendix A includes the literature searches from the original report and the specific search strategies … o Sociodemographic risk factors KQ 1: Children with chronic OME (allow study-specific definitions of … Global and otitis-specific child and parental quality of life 2. Speech and language outcomes 3. … Global and otitis-specific child and parental quality of life o Intermediate outcomes 1.

2068. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
      November 24, 2014 - This specific question relates to risk of bias considerations (rather than grading strength of evidence … Specific recommendations for study design, dosing, monitoring antibiotic levels should be included … believe that a recommendation this specific is applicable. … Peer Reviewer #2 Discussion/ Conclusion More discussion of MICs and specific organisms in the … Is there a way to advise in the power and the specific outcomes that need to be measured?

2069. Medicare Prescription Drug Data Development: Methods for Improving Patient Safety and Pharmacovigilance Using Observational Data | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/patient-safety-databases-prescriptions/research
      August 26, 2008 - Sex-specific analysis. … Sex-Specific Analysis Of the 880 female-specific diagnoses, only 11 (0.1 percent) occurred in males … No male-specific disorders were identified in females. … Not Female-Specific Female-Specific Female 93,784 869 94,653 69.36% 0.64% 70% Male … If we focus on more granular outcomes by examining specific drugs and/or specific adverse event codes

2070. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/methodological-recommendations-framework-communications/research
      September 09, 2013 - Finally, giving specific methods guidance for addressing difficult or ill-defined problems can be premature

2071. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/inguinal-hernia_research-protocol.pdf
      August 15, 2011 - Within each of these categories, several specific procedures have been employed. … Non-sutured “tension-free” surgical mesh gained in popularity, and many specific open procedures were … Specific aspects about mesh repair that may influence outcomes are the type of mesh (e.g., lightweight … These mesh-specific issues are covered by specific Key Questions (see Key Questions below). … Procedure category, specific procedure, specific mesh (if applicable), fixation method (if applicable

2072. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
      November 22, 2011 - The observation that specific CYP2C19 variants or levels of on-treatment platelet reactivity above a … Other potential modifiers of the utility of genetic and phenotypic test results include the specific … The precision of estimates of analytic validity depends on the specific statistic used; generally, a … Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug … On some specific reports, such as reports requested by the Office of Medical Applications of Research

2073. Psychological Treatments and Pharmacological Treatments for Adults with Post-traumatic Stress Disorder (PTSD) | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/ptsd-adult-treatment/research-protocol
      December 20, 2011 - Subsequently, the selection of specific psychotherapies, or specific pharmacologic interventions, may … Eclectic psychotherapy refers to a general class of therapies rather than to a specific intervention … They are selected to provide broad expertise and perspectives specific to the topic under development … Requires patient to associate each symptom with a specific traumatic event. 15-minute administration … There are three versions of the PCL: PCL-M (military), PCL-C (civilian), and PCL-S (specific). 5–10

2074. Traumatic-Brain-Injury-Rehabilitation Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
      June 01, 2012 - Research during the 1970s and 1980s suggested that domain-specific training may be insufficient to … In addition, many treatments target specific functional difficulties regardless of etiology. … • Only included impairment-specific interventions. … Other programs described outreach to TBI survivors;40 community-based care;36 specific approaches to … Further guidance that would match measures most appropriate for specific patients and interventions

2075. Gout Dx protocol_140715-draft (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
      January 01, 2014 - As recommended by the Methods Guide for Medical Test Reviews,11 the searches will not use filters specific … Manufacturers of diagnostic equipment (polarizing microscopes) will be contacted for unpublished data specific … This input is intended to ensure that the key questions are specific and relevant. IX. … They are selected to provide broad expertise and perspectives specific to the topic under development … provide information to the EPC to identify literature search strategies and recommend approaches to specific

2076. Disposition of Comments Report for Treatment of Atrial Fibrillation (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_disposition-comments.pdf
      June 28, 2013 - We have added in tamponade as a specific adverse event in the figure as suggested. … TEP #1 ES (Discussion/ Conclusion) Specific comments: 1. … We do however now list the specific guideline reference for Figure 1 as suggested. … TEP #6 Introduction No specific concerns Thank you. … In addition, the data is insufficient for this specific comparison/outcome.

2077. PowerPoint Presentation (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-strength-evidence.ppt
      June 01, 2012 - Grading the strength of evidence Challenges specific to diagnostic tests Principles of grading the strength … Challenges Specific to Diagnostic Tests (1 of 2) Singh S, Chang SM, Matchar DB, et al. … Challenges Specific to Diagnostic Tests (1 of 2) One common challenge faced by reviewers of diagnostic … Challenges Specific to Diagnostic Tests (2 of 2) Singh S, Chang SM, Matchar DB, et al. … Challenges Specific to Diagnostic Tests (2 of 2) A second challenge faced by reviewers is applying the

2078. PowerPoint Presentation (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-strength-evidence.ppt
      June 01, 2012 - Grading the strength of evidence Challenges specific to diagnostic tests Principles of grading the strength … Challenges Specific to Diagnostic Tests (1 of 2) Singh S, Chang SM, Matchar DB, et al. … Challenges Specific to Diagnostic Tests (1 of 2) One common challenge faced by reviewers of diagnostic … Challenges Specific to Diagnostic Tests (2 of 2) Singh S, Chang SM, Matchar DB, et al. … Challenges Specific to Diagnostic Tests (2 of 2) A second challenge faced by reviewers is applying the

2079. Comparative Effectiveness of Noninvasive Technologies for the Diagnosis of Coronary Artery Disease (CAD) in Women | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/cad-women-diagnosis/research-protocol
      December 08, 2010 - Exercise ECG has been recognized in the literature as being less sensitive and specific for diagnosing … Despite sex-specific limitations, existing ACC/AHA guidelines propose that evidence of sex-specific limitations … which is summarized below. 7 These recommendations are made for the general population and are not specific … Grading will be outcome-specific; thus, a given study may be graded to be of different quality for two … Technical Expert Panel (TEP) A TEP panel is selected to provide broad expertise and perspectives specific

2080. Renal-Cancer Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_executive.pdf
      February 01, 2016 - be used for research purposes, but should not be considered current. 2 However, the cancer-specific … survival is highly stage dependent, with a greater than 95 percent 5-year disease specific survival … for stage T1 tumors, and greater than 85 percent 5-year disease specific survival for stage T2 tumors … Most tumors are detected incidentally during an evaluation for unrelated or non-specific complaints … with clinical stage T1a (≤ 4 cm), T1b (> 4-7 cm) and T2 (> 7 cm) tumors, resulting cancer-specific