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Total Results: 1,372 records

Showing results for "small".

141. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - a systematic process that involves compiling information on topics and issuing topic drafts to a small … Ivacaftor (Kalydeco ™ , VX- 770, Vertex Pharmaceuticals, Inc., Cambridge, MA) is a small-molecule, … However, because of the small patient population and the drug’s oral administration, ivacaftor is not … the importance of this unmet need is tempered because CF is a rare condition and that within the small … annually, which the reviewer regarded as an unsustainable trend for a disease that affects such a small

142. Omega-3 Fatty Acids and Cardiovascular Disease: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_clinician.pdf
     July 01, 2017 - Second, they cause small increases in both high-density lipoprotein cholesterol (HDL-c) and low-density … Finally, marine oil supplements produce small changes in the ratio of total cholesterol to HDL-c (high … supplements was associated with a statistically significant decrease in the concentration of TGs and a small

143. Rotator-Cuff-Tear-Surveillance-140925 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear-surveillance-140925.pdf
     February 01, 2014 - However, new evidence from one small RCT45 showed significant differences in ASES (98.9 vs. 94.8 … Clinical outcome in all-arthroscopic versus mini- open rotator cuff repair in small to medium-sized … Single- row versus double-row arthroscopic rotator cuff repair in small- to medium- sized tears. … Single-row versus double-row arthroscopic rotator cuff repair in small- to medium-sized tears. … The three comparative studies were relatively small and no overall conclusions were possible.

144. Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/Evidence%20Summary_1.pdf
     April 01, 2020 - In adults with mild to moderate CATD— ■ Cholinesterase inhibitors compared with placebo produced small … – In adults with moderate to severe CATD— ■ Cholinesterase inhibitors produced small improvements … Studies for both cognitive and biomarker tests were limited by small sample sizes. … However, average differences for cognition and function between treatment groups were small, with … This was largely due to small sample sizes and inconsistent results within and between trials.

145. Liver-Cancer Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
     October 01, 2014 - did not perform meta-analysis on staging accuracy and intermediate or clinical outcomes due to the small … Since likelihood ratios are sensitive to small changes in estimates 9 when the specificity is high … FDG PET found sensitivity increased as lesion size increased, but the number of lesions <1 cm was small … US without contrast plus CT Low One cohort study found that contrast-enhanced US identified more small … Research should focus on improving methods for identifying small or well-differentiated HCC lesions

146. Understanding Health-Systems’ Use of and Need for Evidence To Inform Decisionmaking (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-systems-research.pdf
     October 01, 2017 - enhancing health-system quality, safety, and process improvement from academic, non-academic, and small … Some KIs, especially those in small and rural health-systems, noted that they want to be able to obtain … The small/rural KIs did not have access to these specialized services. … For some health-systems, especially the small and rural ones, most of the evidence is handled locally … Conclusion There are difference between large and small health-systems in terms of the personnel who

147. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-update-disposition-170621.pdf
     March 16, 2017 - three studies are more stable than those from two studies, though the number of studies is still small … In general the number of studies included in the metaanalyses were small, in particular, for the within … Peer Reviewer 9 Methods Methods for publication bias (small study effects) were mentioned but no results … Given the typical small sample sizes within studies, imbalance between groups is likely to occur. … We have commented on the imprecision for several drugs due to small samples, and have run an adjusted

148. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
     March 16, 2017 - three studies are more stable than those from two studies, though the number of studies is still small … In general the number of studies included in the metaanalyses were small, in particular, for the within … Peer Reviewer 9 Methods Methods for publication bias (small study effects) were mentioned but no results … Given the typical small sample sizes within studies, imbalance between groups is likely to occur. … We have commented on the imprecision for several drugs due to small samples, and have run an adjusted

149. Ankyloglossia Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ankyloglossia_executive.pdf
     May 01, 2015 - considered the strength of evidence for reoperation and pain as harms to be insufficient, given the small … ) High Consistent Indirect Imprecise Undetected Insufficient SOE for all feeding outcomes, given small … 4 poor23,24,40,41 (4,080) High Consistent Direct Imprecise Suspected Insufficient SOE due to very small … Conclusions A small body of evidence suggests that frenotomy may be associated with improvements in … However, with small, inconsistently conducted studies, strength of evidence is low to insufficient,

150. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
     January 01, 2012 - a systematic process that involves compiling information on topics and issuing topic drafts to a small … Ivacaftor (Kalydeco ™ , VX- 770, Vertex Pharmaceuticals, Inc., Cambridge, MA) is a small-molecule, … However, because of the small patient population and the drug’s oral administration, ivacaftor is not … annually, which the reviewer regarded as an unsustainable trend for a disease that affects such a small … Small arteries throughout the lungs narrow, increasing resistance to blood flow through the lungs.

151. PKU Surveillance Assessment_CER 56_Low (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
     January 15, 2013 - Of the ten studies that evaluated the effects of BH4 in patients with PKU (relatively small, ranging … One small case series reported on IQ and nutritional outcomes for up to 1 year on 5 mg/kg/day BH4 … A small Phase 2 trial of PEGylated phenylalanine ammonium lyase (PAL), an enzyme that breaks down Phe … phenylalanine; PKU phenylketonuria; SCEPC Southern California Evidence-based Practice Center; SGA small … Of the ten studies that evaluated the effects of BH4 in patients with PKU (relatively small, ranging

152. Treating and Preventing C. difficile Infections (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_consumer.pdf
     May 01, 2017 - Small amounts of C. difficile bacteria are even found in many people’s intestines. … When this Large Intestine C. difficile bacteria Small Intestine happens, bacteria such as C … To do this, your health care professional takes a small amount of stool containing healthy bacteria

153. Cancer-Drugs-Utilization Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-drugs-utilization_research.pdf
     January 01, 2011 - 15.44 8.09 22.79 58.09 † † 12.50 † † 25.00 8.09 † † † Suppressed to remain compliant with CMS’ small-sized … beneficiaries with an order for the biologic, indicative of its labeled indication for the treatment of non-small … advanced renal cell carcinoma and hepatocellular carcinoma, and off-label use in melanoma and non-small … White corresponds to areas that lack an HRR 44.44 - 61.54 61.54 - 67.97 67.97 - 76.67 76.67 - 100.00 Small-sized … corresponds to areas that lack an HRR 40.00 - 75.00 75.00 - 81.25 81.25 - 85.94 85.94 - 100.00 Small-sized

154. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final_0_0.pdf
     March 01, 2022 - • Comparable THC to CBD ratio oral spray is probably associated with small improvements in pain … Comparable THC to CBD Ratio Benefits and Harms Benefits: small improvements in pain severity and … a Potential effect: SOE of low or higher; findings indicate at least a small magnitude of effect but … Magnitude of benefit was categorized into no effect or small, moderate, and large effects. … Improvement in pain was small to moderate with high and comparable THC to CBD ratio products.

155. Disposition of Comments: Comparative Effectiveness Review No. 232_Interventions for Breathlessness in Patients With Advanced Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
     November 19, 2020 - The number of studies were already very limited, the sample sizes were small, not all reported these … Many of the studies were small, pilot trials and designed to estimate the within-group effect instead … It is only a small paragraph here but this needs to be emphasized a lot more. 1. … I worry the included articles represent a small subset of data that can inform the authors' questions … This seems small and arbitrary - Mazzocato C et al, Ann Oncol, 1999 could be included as an example

156. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
     November 01, 2009 - For non-small-cell lung cancer and hepatocellular carcinoma, patients who either refused surgery or … Most eligible studies were noncomparative in nature and had small sample sizes. … Brachytherapy Brachytherapy is another type of radiation therapy where one inserts small encapsulated … For example, particle beam therapy was used in patients with non-small cell lung cancer (most stage … Hypofractionated high-dose proton beam therapy for stage I non-small-cell lung cancer: preliminary

157. Disposition of Comments Report for Treatments for Ankyloglossia and Ankyloglossia With Concomitant Lip-Tie (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ankyloglossia_disposition-comments.pdf
     May 04, 2015 - TEP reviewer #2 Results Small white patch at base of tongue is healing slough, normal stage in … TEP reviewer #3 Discussion/ Conclusion Rather than stating "A small body of evidence suggests that … Even though the studies were small, this is an important finding. … The reason for the low SOE is the small number of infants studied, the need for longer term outcomes … Maybe something more like: A small body of evidence suggests that frenotomy performed on infants with

158. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Primary Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
     March 01, 2022 - • Beneficial effects were usually considered small to moderate for both program types. … • Only a small number of studies have evaluated opioids. … • Although only studied in one or a few small trials, several nonpharmacological treatments for … Key Messages • Opioids are associated with small improvements versus placebo in pain and function, … • Small to moderate, dose-dependent increases in withdrawal due to adverse events were found with

159. Sleep-Apnea Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_surveillance.pdf
     April 01, 2012 - Largely due to small sample size, the reported effect estimates in the studies reviewed were generally … Five small, highly clinically heterogeneous trials (one quality B, four quality C) with largely null … Overall, the studies were clinically heterogeneous, small, and of quality B (three studies) or C (two … Studies generally had small sample sizes with less than 1 year of followup. … Studies generally had small sample sizes with less than 1 year of followup.

160. Restless-Legs Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
     November 01, 2012 - • One small crossover trial found no significant improvement in IRLS scores with dopamine agonist … • Four small RCTs18-21 addressed nonpharmacologic interventions. … The effect size was small to medium in magnitude (SMD=-0.37 [95% CI, -0.48 to -0.27]). … The magnitude of effect was small to moderate. Strength of evidence was high. … Two small, good quality RCTs evaluated iron therapy (one intravenous and one oral) in patients with