-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_disposition-comments.pdf
August 12, 2016 - Some of the exclusions of
studies on the basis of sample size seem arbitrary: for example, studies of … limitations of statistical
inference when sample sizes of endpoints are limited in studies of fixed
size … The sample size was too
small (N<30) in each arm at
1 year followup. … By some
criteria, based on their larger
size (than omitted studies),
they are likely to have been … All those that were
not included had already
been rejected (mostly based
on sample size, too-short
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_disposition-comments.pdf
April 15, 2013 - tend to reduce the persuasiveness of intervention restudies for the following
reasons: small sample size … sense of the effectiveness of an intervention:
Our findings suggest that the magnitude of the effect size … A., et al. (2004) Effect size in cumulative meta-analyses of mental
health randomized trials evolved … This
proclivity is particularly misleading when the size of the sample is small: Twersky and
Kahneman … maltreated children. 26 studies (many focusing on the
same interventions) is a rather limited sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_surveillance.pdf
July 01, 2012 - a
statistically
significant effect of
the following
factors on the
accuracy or harms:
needle size … Brennan (2011)
conducted a meta-analysis
of 52 studies including
7,350 lesions and found
needle size … (14 gauge vs 11
gauge), lesion size > 20mm,
and palpability associated
with misclassification. … Meta-analysis of 52 studies:
DCIS underestimation rate
23.9% ND
14 gauge (vs 11 gauge),
lesion size … identify a
statistically significant effect of the following
factors on the accuracy or harms: needle size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
April 01, 2013 - We did not perform
additional effect size calculations, with the exception
of one study that provided … the effect size without the
significance level.22
Strength of Evidence Grading
We graded the strength … in the field.
f One comparator is a conventional approach; the other is a derived approach.
g Effect size … Interpretation of the effect size as small, medium, or large is defined as Cohen’s d = 0.20, 0.50, and … a powerful platform that could efficiently
furnish collaborative studies of sufficient quality and size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4.pdf
January 01, 2023 - The new study was assessed as high risk of bias and
had a small sample size (n=60).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_executive.pdf
October 01, 2012 - because of
inconsistent reporting of outcomes across studies and frequent lack of reporting of effect size … research in this field could be improved by
recruitment and retention efforts to assure adequate sample
size
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-quality.ppt
January 01, 2010 - Individual Study to the Body of Evidence
Quality (systematic error and inferential error, type of study)
Size … The size of the study could result in nonsystematic or random error; it influences considerations of … providers
Additional Criteria for Trials
Additional Criteria for Observational Studies (I)
Sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-immunodeficiency-virus-rapid-response.pdf
May 01, 2025 - • All three non-comparative studies were small (sample size: 15 to 63), with follow-up
duration … We rated all three studies as poor quality
(having high risk of bias), due to small sample size, high … Outcome Timing; Subgroup
(Sample Size)
Results P Value
Nobreb
201931
Brazil
Single-arm … Outcome Timing; Subgroup
(Sample Size)
Results P Value
Valentined
201630
US
Single-arm … Of
these three included studies, two were small, with sample size of less than 25,31,32 and the third
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
June 01, 2011 - Inconsistent or Unknown Consistency Results
Inconsistent information arises when estimates of effect size … If
there is only one available study, even if considered large sample size, the consistency of results … be kept in mind that a
statistically significant effect size in one study and an effect size whose … If there is only
one available study, even if considered large sample size, the consistency of results … However, it should be kept in mind that a statistically significant
effect size in one study and an
-
effectivehealthcare.ahrq.gov/sites/default/files/cognitive-decline-disposition-170707pdf.pdf
March 24, 2017 - The sample size
threshold is only for observational studies;
RCTs of any size were eligible. … We clarified the
text:
“For KQ1-2: RCTs of any size and large
prospective quasi-experimental cohort … Randomized controlled trials of any size were
eligible. … We clarified the text: “For KQ1-2: RCTs
of any size and large prospective quasi-
experimental cohort … We agree that an effect size of 0.66
after 10 years is relatively large in magnitude,
but it needs
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline-disposition-170707pdf.pdf
March 24, 2017 - The sample size
threshold is only for observational studies;
RCTs of any size were eligible. … We clarified the
text:
“For KQ1-2: RCTs of any size and large
prospective quasi-experimental cohort … Randomized controlled trials of any size were
eligible. … We clarified the text: “For KQ1-2: RCTs
of any size and large prospective quasi-
experimental cohort … We agree that an effect size of 0.66
after 10 years is relatively large in magnitude,
but it needs
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0351_05-10-2010.pdf
January 01, 2010 - therapies, different surgical techniques
Outcome(s): diagnostic ability of test, final testicular size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
March 01, 2015 - The following data were abstracted for
each category: author, year, country, treatment, dose, trial
size … standardized
mean differences from pairwise comparisons
Number of
Comparisons Comparators Effect Size … standardized mean
differences from pairwise comparisons
Number of
Comparisons Comparators Effect Size … Domain
Number of
Comparisons Comparators
Effect Size (SMD)
(95% CI)
Strength of
Evidence
Global … mean
differences from pairwise comparisons
Domain and Number
of Comparisons Comparators
Effect Size
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/masks-appendix-table-b-2-version-1.xlsx
January 01, 2007 - Retrieved Source Link/URL Study Design Study Dates Geographic Setting Setting Inclusion Criteria Sample Size
-
effectivehealthcare.ahrq.gov/sites/default/files/masks-appendix-table-b-2-version-2.xlsx
January 01, 2007 - Retrieved Source Link/URL Study Design Study Dates Geographic Setting Setting Inclusion Criteria Sample Size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
June 01, 2012 - compared to standard treatment at an outpatient
rehabilitation center resulted in a moderate effect size
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiation-therapy-brain-metases-protocol.pdf
October 10, 2019 - For patients with good prognosis (expected survival of 3 months or
more), the number, size and resectability … Does the effectiveness depend on tumor size or radiation dose and
fractionation and, and again, should … providers need to evaluate existing evidence on whether the effectiveness varies with
tumor type, size … study), key question
contribution (effects, adverse events, both), number of participants (study
size … We will highlight the direction and size of effect narratively in addition to providing the
numerical
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
June 01, 2010 - quality of a body of observational studies is downrated (with respect to RCTs) unless the effect
size … Association between unreported outcomes and
effect size estimates in Cochrane meta-analyses. … Includes
sample size, number of studies, and
heterogeneity within or across studies. … Greater levels of precision may be needed if the
estimates of the effect size of benefits and harms … The size of the trial, the rigor
of its execution, the broad spectrum of adults who were enrolled, and
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
June 01, 2010 - quality of a body of observational studies is downrated (with respect to RCTs) unless the effect
size … Association between unreported outcomes and
effect size estimates in Cochrane meta-analyses. … Includes
sample size, number of studies, and
heterogeneity within or across studies. … Greater levels of precision may be needed if the
estimates of the effect size of benefits and harms … The size of the trial, the rigor
of its execution, the broad spectrum of adults who were enrolled, and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
April 30, 2014 - We have provided additional study design
recommendations, particularly with respect to
sample size … These
analyses did not reveal an association between
year of publication and estimated effect size. … We have provided details about the sample size
requirements for such a trial. … We believe that the
required sample size is not prohibitive (even for a
small size consortium) given … As
stated by the authors of the study, the quality and the size of the
randomized controlled trials