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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_disposition-comments.pdf
August 21, 2013 - Commentator &
Affiliation Section Comment Response
specific strengths and weaknesses, such as sample size … Why were these
latter effect size computed? … A single effect size
that represents the treatment and comparison contrast
(possibly adjusted for pre-test … odds-ratio to a standardized mean
difference using well established methods), the overall
mean effect size … somewhat imprecise (I’m still not
clear on the threshold for precision) but of a clinically
meaningful size
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-update-disposition-170621.pdf
March 16, 2017 - Did the studies
provide adjusted estimates for effect size? … TEP 7 Methods [page 68]: Authors mention precision evaluated "on
the basis of sample size and, if size … In the full report, we
removed the clause “and, if size is adequate,
the degree of certainty”, and … added later when
describing the methods for rating down in the
other context, “When sample size was … We
realized that 2 of the analyses did not split the
sample size for one control group and we re-did
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
March 16, 2017 - Did the studies
provide adjusted estimates for effect size? … TEP 7 Methods [page 68]: Authors mention precision evaluated "on
the basis of sample size and, if size … In the full report, we
removed the clause “and, if size is adequate,
the degree of certainty”, and … added later when
describing the methods for rating down in the
other context, “When sample size was … We
realized that 2 of the analyses did not split the
sample size for one control group and we re-did
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_disposition-comments.pdf
June 10, 2013 - section:
In general, for school-based intervention studies, we found those that had
large sample size … Conversely,
"Consumer health informatics" is included in this
list (same level and font size), although … 3 Executive
Summary
Page 12, Table 2: seems like it would be of real
interest to add the effect size … the components of the interventions in the tables
105 TEP 1 Methods Not clear how was the sample size … Perhaps One
could define a lowest cutoff for sample size, or a
stratification scheme.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_consumer.pdf
June 01, 2016 - An IH can range in size. It may stay as small as the tip of a crayon. … Once the IH reaches its largest size, it usually starts to shrink and
fade. … child’s health care professional recommends
depends on many things, such as your child’s age and the size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_executive.pdf
August 01, 2013 - If data from a study permitted, we calculated individual
study effect-size estimates. … For dichotomous outcomes, we used
the odds ratio as the measure of effect size; values greater
than … We used calculated effect-
size estimates to help determine the overall strength of the
evidence. … Precision is a measure of the
degree of certainty around a single outcome’s effect size. … Effect-
size indices for dichotomized outcomes in meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
June 01, 2010 - Inclusion and exclusion criteria based on study size have not yet been finalized. … The
Evidence-based Practice Center (EPC) will record the size of any study that would be excluded
only … because it has fewer than 20 participants; the EPC will then set a study size cut-off based on
the … elements (e.g., author,
publication year, study location, time period, population description, sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
January 15, 2016 - (RCT of
beta-blockers, standardized rating systems for size/volume/
change in appearance). … treatment effects and that
clinicians and families may take factors such as lesion location, type, size … Families and clinicians
making treatment decisions should also factor in elements such as lesion
size … Families and clinicians
making treatment decisions should also factor in elements such as lesion
size … We have noted that lesion size, type, and location may dictate treatment
choices; however, the studies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_executive.pdf
August 01, 2013 - Anxiety
symptoms
136 Insufficient for LLLT A single study with high risk of bias and small sample size … Depression
symptoms
136 Insufficient for LLLT A single study with high risk of bias and small sample size … Effect-
size estimates were inconsistent or imprecise, and risk of
bias was moderate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - Sample size calculations should ensure
adequate power to test selected predefined hypotheses and take … Resource use, size, and
duration
RCTs are difficult to recruit to,
require large sample sizes and … Resource use,
size, and
duration
Resource use is less than an RCT or
even an Observational study … Resource use,
size, and
duration
Minimal, study can be conducted by
secondary data analysis. … Sample size will need to be large given the
number of treatment options available.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-comments.pdf
May 21, 2020 - Disposition of Comments for CER 225: Substance Abuse Disorders in Adolescents
Comparative Effectiveness Review Disposition of Comments Report
Research Review Title: Interventions for Substance Use Disorders in Adolescents:
A Systematic Review
Draft report available for public comment from Octob…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - Requires
planning to balance baseline characteristics and
sample size considerations. … Resource use, size
and duration
Depending on the strategy and desired effect
size, costs, sample … size and staff time needed
for recruitment and implementation could be
high. … Otherwise, size and duration
issues would be similar to RCT. … Resource use, size
and duration
Recruitment could be an issue due to willingness to be
randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
March 29, 2011 - As an inclusion criterion, we will set the cut-off level for study size at a minimum of 20 participants … We selected this study size based on a previous review of therapies
http://www.effectivehealthcare.ahrq.gov … A cutoff sample size of 20 provides a balance, allowing us to review
and comment on adequate literature … In particular,
the TEP noted that a sample size of 20 for studies of all types of interventions (e.g … publication, study location
(e.g., country, city, state) and time period, population description, sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
May 26, 2017 - Peer
Reviewer #7
Methods Almost all of the studies reviewed are noted to have "small" sample size, … Moreover, most
studies noted as a limitation their small sample
size. … We set the sample size criteria of 10 for RCTs
and 20 for other types of studies in
consultation with … We selected a minimum sample size of 10 for
RCTs because we felt that the typically greater
controls … for bias and rigor helped to mitigate
limitations of a smaller sample size.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
February 01, 2013 - What variables (risk factors)
are associated with progression of fatty atrophy and tear size? … What variables (risk
factors) are associated with progression of fatty atrophy and tear size? … The sample size was limited by the Paperwork Reduction Act and
Information Collections Policy (44 USC … What variables (risk factors) are
associated with progression of fatty atrophy and tear size? … What variables (risk factors)
are associated with progression of fatty atrophy and tear size?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
May 01, 2010 - These hospitals are nationally representative
based on bed size, geographic location, designation
(urban … three criteria were unique to
either RCTs (methods of allocation) or observational
studies (sample size … The former, the risk
difference, was chosen as a measure of effect size for
6
the report because … The strength of
evidence available from existing studies was thereby
compromised by small study size, … • There may be greater benefits in younger patients
with smaller initial hematoma size.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - Choosing a model
• Factors affecting model choice include:
► Number and size of included studies
► Type … • Factors affecting model choice include the number and size of included
studies, and type of outcome
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-200-comments-post-acs.pdf
November 14, 2017 - is unlikely to have a significant effect on
cardiovascular outcomes, especially mortality, in the size … Presenting
the results in effect size changes would be much more
meaningful to readers. … It might be useful to describe this
difference as a standardized effect size. … criteria were too
restrictive, but they were developed
with input from KI/TEP and public to
match the size … depression and co-morbid diabetes
and CAD led by Katon et al. that reported particularly
strong effect size
-
effectivehealthcare.ahrq.gov/products/effect-dietary-digestible/protocol
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-march-2023-grand-rounds-slides.pdf
January 01, 2023 - 0 0 3 14
Total 19 25 12 28 84
Study Design Considerations con’t
Study Sample Sizes
• Sample size … equivalence)
• Sample size requirements vary by outcome measure, and baseline risk for the
outcome