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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-update_disposition-comments.pdf
    August 06, 2014 - of care for individuals with ASD. … This is a very confusing statement, as it suggests that of the 51 new studies, only six were RTCs. … We have clarified the statement to note “Six RCTs (five good and one fair quality) of interventions … in various domains (IQ adaptive behaviour etc.) … and grids of the research studies, results, applicability to targeted domains.
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - The strength of evidence for each outcome or comparison that we graded incorporates scores on four domains … Maintenance of Response or Remission (KQ 2a) Efficacy and Effectiveness Six head-to-head RCTs suggest … Six studies provided mixed evidence for the superiority of duloxetine or paroxetine compared with placebo … Sexual Dysfunction Six trials and a pooled analysis of two identical RCTs provide evidence that bupropion … Comparative risk of sexual High Results from six trials indicate that bupropion causes significantly
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
    October 04, 2016 - summarize the process and recommendations from their needs assessment.9 The Working Group identified six … system that conforms with the EPC Methods Guide recommendations on grading the SOE.10,23 The primary domains … Additional domains may be used when appropriate, including dose-response association, strength of association … Below, we discuss the primary domains and how they will be considered as inputs to the ratings: Risk … of bias (see the section Assessment of Methodological Risk of Bias of Individual Studies above).
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autoimmune-disease-rapid-research.pdf
    November 01, 2024 - system leaders, and policymakers, among others—make well-informed decisions and thereby improve the qualityof healthcare services. … in the US; six studies were conducted in Asia35–39,41 and four were in Europe.33,34,40,42 3.2.3 Results … studies, patients in the control group received oral health instructions (OHI),37,39,41,42 and the other six … Nguyen 2021 reported that six months after receiving SRP and OHI, patients in the treatment group had
  5. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - No statement in this report should be construed as an official position of AHRQ or of the U.S. … the case of new applications of already- diffused technologies. … compiled and sent for expert comment before November 6, 2015, in this priority area; and (3) we received six … Results and Discussion of Comments Six experts, with clinical, research, and health systems backgrounds … Six- months outcomes of a randomised trial of supportive text messaging for depression and comorbid
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
    June 10, 2024 - Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by persistent symptoms in the domains … ADHD or other domains of functional impairment, the costs of treatment, and the likelihood of side … of adverse events reporting.110, 111 We will assess the six domains selection, detection, performance … The strength of the evidence can be downgraded based on the outlined domains. … evidence statement was assigned by evaluating and weighing the combined results of the above domains
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
    January 08, 2025 - Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by persistent symptoms in the domains … ADHD or other domains of functional impairment, the costs of treatment, and the likelihood of side … the six domains selection, detection, performance, attrition, reporting, and study-specific sources … The strength of the evidence can be downgraded based on the outlined domains. … evidence statement was assigned by evaluating and weighing the combined results of the above domains
  8. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - the case of new applications of already-diffused technologies. … compiled and sent for expert comment by October 27, 2013, in this priority area; and we received six … opioid blockade of relevant doses of agonists  The effect of higher doses of Probuphine, ideally … Because of the multifaceted approach of Project Lazarus, determining the impact of each individual … Results and Discussion of Comments Six experts, with clinical, research, health devices, and health
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/trauma-child-interventions_research-protocol.pdf
    March 26, 2012 - Interventions designed to prevent or treat traumatic stress symptoms exist within the domains of psychotherapy … To provide a comprehensive review, we include all intervention domains for questions of prevention as … child-parent relationship is used to target the child’s improvement in emotional, cognitive, and social domains … The NST phase of treatment is conducted in six individual sessions that focus on the emotional processing … domains: risk of bias (including study design and aggregate quality), consistency, directness, and
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
    March 19, 2018 - as well and the formoterol has a 8‐ 12 hour duration but the albuterol or terbutaline has a two to six … The specific domains which contributed to the downgrading of all outcomes, organized per KQ, appear … when grading those domains. … ROB was taken into account when SOE was graded, as one of the domains. … ROB was taken into account when SOE was graded, as one of the domains.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
    October 05, 2018 - Titles and abstracts will be reviewed by two of our six independent research staff assigned to this … All studies forwarded for full-text screening will be independently evaluated by two of six investigators … different domains, and then, considering these assessments, also rate its overall risk of bias as low … domains and overall. … Individual strength of evidence domains will be: (1) study limitations (risk of bias); (2) directness
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_surveillance.pdf
    April 01, 2016 - (SOE: Low) of seizures in a patient with seizure history, and six cases of suicidal ideation (in … cognitive impairment had improvement in depression symptoms at six weeks and six months, whereas … and psychological domains but not social or environmental. … Other cognitive domains included category fluency (semantic memory) and letter fluency (lexical memory … History, and six cases of suicidal ideation (in patients with history of suicidal ideation).
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
    March 01, 2012 - determined by any one of six methods, all imperfect. … The evidence grade is based on four primary domains (required) and four optional domains. … The required domains are risk of bias, consistency, directness, and precision; the additional domains … • There is a high level of evidence, based on six previously published systematic reviews, that there … Moderate Based on six RCTs, superiority for the prevention of fractures has not been demonstrated for
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
    December 01, 2010 - When compared to FGAs, SGAs have shown greater benefits in many outcome domains,9 and newer medications … by using the Cochourane Collaboration Risk of Bias tool.21 This tool consists of six domains (sequence … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … This approach assesses the evidence based on four domains: risk of bias, consistency, directness, and
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholder-engagement_research.pdf
    September 01, 2011 - of health care services. … of health care in the United States. … care quality. … conference calls and six in-person meetings. … After careful review and consideration of six sample CERs, members of the Product Development Work
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_executive.pdf
    April 01, 2012 - domains: (1) risk of bias criteria; (2) consistency of results (degree to which study results for … Twenty-six of 33 studies evaluated combination therapies that included augmenting agents. … Combined Therapies Versus Combined Therapies in Adults There were six studies (n=832)35,47,59,62,68,75 … The domains within the AGREE II showed great variability in the scores, suggesting significant differences … Domains with the greatest variability included domain 3 (rigor of development), domain 5 (applicability
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_executive.pdf
    November 01, 2013 - Search Strategy Six databases (Medline®, Embase™, AMED, Cochrane Central Register of Controlled Trials … Primary Endpoint A composite of endpoints was used in six studies,168,170,171,173-175 two studies used … Overall the SOE was rated as low, as two domains (consistency and precision) were not met. … of six studies168-172,175) and ARB (one170 of five studies168-171,175) in the BNP/NT-proBNP group compared … However, it was observed that the majority of studies had high risk of bias in two main domains: control
  18. effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - compiled and sent for expert comment before October 27, 2013, in this priority area; and (3) we received six … 65 and older) to improve safety, outcomes, and quality of care and to reduce admissions and lengths … Ineffective planning and lack of an effective transition can lead to lapses in the quality of care, … Results and Discussion of Comments Six experts, with clinical, research, and health systems backgrounds … Comments Six experts, with clinical, research, and health systems backgrounds, offered perspectives
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
    August 23, 2023 - Drivers for adoption of LCA include comparison of single-use and reusable devices and evaluation of … Grave describes the end-of- life phase of a product. … For this project we selected six scopes of interest (with the option of expanding to further content … ) and quantitative (e.g., complexity of the model) domains to provide a comprehensive and useful overview … Application of Markov Chain Model to Calculate the Average Number of Times of Use of a Material in Society
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-map-hcbs-protocol.pdf
    July 27, 2023 - Discussions with Key Informants We plan to recruit six to nine KIs with different expertise, backgrounds … quality of service? … life (see NQF HCBS Quality Domains Report) • Harms of the intervention • None Timing • All • None … Summary of Protocol Amendments In the event of protocol amendments, the date of each amendment will … Role of the Funder

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