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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-opioid-stewardship-protocol.pdf
    July 01, 2023 - (NQF) identified fundamental actions to support opioid stewardship in healthcare organizations,5 six … Purpose of the Review The overall purpose of this review is to determine the effect of opioid stewardship … Cochrane Collaboration’s tool that cover the domains of selection bias, performance bias, detection … of the reported results.8 The risk of bias assessments will focus on the main outcome of interest … If any of the PSPs have more than one study of effectiveness, we will grade the strength of evidence
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Three scales met all six criteria the authors considered important: Cochrane Methods Working Group checklist … An updated version (QUADAS-2) identifies four key domains rated in terms of risk of bias: Patient selection … An updated version of this scale, called QUADAS-2, identifies four key domains, each of which are rated … These four domains are patient selection, index test or tests, reference standard, and flow and timing … under the four domains of patient selection, index test(s), reference standard, and flow and timing.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Three scales met all six criteria the authors considered important: Cochrane Methods Working Group checklist … An updated version (QUADAS-2) identifies four key domains rated in terms of risk of bias: Patient selection … An updated version of this scale, called QUADAS-2, identifies four key domains, each of which are rated … These four domains are patient selection, index test or tests, reference standard, and flow and timing … under the four domains of patient selection, index test(s), reference standard, and flow and timing.
  4. effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children-update/research-protocol
    April 01, 2020 - onset in the adolescent sample was six. … ; 34 from National Survey of Adolescents data, the six-month prevalence of PTSD was estimated to be … based on EPC Methods guidance. 44 This tool consists of six domains (sequence generation, allocation … If one or more individual domains are assessed as having a high risk of bias, the overall score will … studies with outlying effect sizes, for studies rated as high risk of bias in some domains such as incomplete
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
    February 01, 2012 - well-informed decisions in designing and funding research and thereby improve the quality of healthcare services. … of health care in the United States. … care quality. … six new topics.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/pdf/ped-mindfulness-protocol-amended.pdf
    September 25, 2024 - We also held discussions with six members of our Technical Expert Panel (TEP). … to assess risk of bias in randomized trials.37 The five domains of the tool are the randomization process … bias rating of “high,” “some concerns,” or “low” for each of the above domains and the overall risk … scale by evaluating and weighing the combined results of the included domains. … Below, we discuss the primary domains and how we will assess them: Risk of bias (see the above section
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-introduction_methods.pdf
    July 01, 2012 - knowledge of providers, availability of therapeutic resources, and so on. … presented by medical tests, a body of test evaluation literature has emerged over the past six decades … In Chapter 7, we discuss the challenges and applications of grading the strength of a body of test … of therapies; in particular, the very great importance of context and the dearth of comprehensive … of health care.
  8. effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children/research-protocol
    December 01, 2019 - normative growth and development, medication adherence and persistence, as well as other important domains … will be assessed using the Cochrane Collaboration Risk of Bias tool. 10 This tool consists of six domains … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … . 17 This approach assesses the evidence based on four domains: risk of bias, consistency, directness
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
    October 29, 2012 - , and New England Journal of Medicine) and six specialty journals (Journal of Urology, International … We identified one RCT that demonstrated significant differences in three domains of quality of life … We identified one RCT that demonstrated significant differences in two domains of quality of life measure … Darifenacin Darifenacin significantly improved urgency UI and several domains of quality of life more … Darifenacin Darifenacin significantly improved urgency UI and several domains of quality of life more
  10. effectivehealthcare-admin.ahrq.gov/products/pelvic-pain/research-protocol
    December 01, 2020 - studies varying from three to greater than six months and the location of pain and pathology largely … pain of at least six months' duration that appears in locations such as the pelvis, anterior abdominal … , satisfaction with care, quality of life, and harms? … the following four major domains: risk of bias (low, medium, high), consistency (inconsistency not present … ratings for the individual domains.
  11. effectivehealthcare-admin.ahrq.gov/products/renal-cancer/research-protocol
    December 01, 2019 - ., radiofrequency ablation, cryoablation; surgical vs. image-guided) Active surveillance (minimum six … If Y or PY to 1.4 : Were confounding domains that were adjusted for measured validly and reliably by … If Y or PY to 1.7 : Were confounding domains that were adjusted for measured validly and reliably by … will be resolved through consensus or third-party adjudication We will consider the five required domains … Additional domains (plausible confounding, dose-response, and magnitude of effect) will be considered
  12. effectivehealthcare-admin.ahrq.gov/products/misuse-prescription
    February 01, 2025 - Definition of Terms VI. Summary of Protocol Amendments VII. … What is the frequency of misuse and how do they differ by type of stimulant, method of ingestion (orally … Assessment of Methodological Risk of Bias of Individual Studies For Key Question 1, on patterns and trends … For Key Questions 2 and 3, on consequences of misuse, we will use the six-item Quality In Prognosis Studies … of interest.
  13. effectivehealthcare-admin.ahrq.gov/products/back-pain-treatment/research-protocol
    December 01, 2019 - Assessment of Methodological Risk of Bias of Individual Studies Predefined criteria will be used to … evidence that includes the major domains of strength of evidence (risk of bias, consistency, precision … at least six to ten studies for continuous variables and four studies for categorical variables. 24 … evidence domains (risk of bias, consistency, precision, directness) based on the totality of underlying … to a four-level scale by evaluating and weighing the combined results of the above domains: High—We
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
    June 01, 2012 - We evaluated SOE based on four required domains (risk of bias, consistency, directness, and precision … certain rehabilitation programs and compared results to those not participating in the program.30-33 SixSix studies were conducted in the United States and two in other countries (United Kingdom and Finland … Six studies assessed comparative effectiveness with respect to productivity outcomes.35, 37, 41-43, … This would enable researchers to better define impairment domains and levels of impairment, which is
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
    July 01, 2012 - of health care in the United States. … care quality. … The properties of a 5-SNP panel were investigated in six articles, four of which also considered family … Across six studies, the range of observed diagnostic ORs for the 5-SNP panel was 2.4 to 4.5. … moderate risk of bias. 5 Rating the Body of Evidence We considered the domains of risk of bias,
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cesarean-birth-2010_research-protocol.pdf
    January 01, 2010 - Six open, active trials were identified in ClinicalTrials.gov that included cesarean birth rate as … For RCTs, the fundamental domains will include: adequate sequence generation, allocation concealment … and Comparative Effectiveness Reviews, 10 which emphasizes the following four major domains: risk … ratings for the individual domains. … of the final draft of the report.
  17. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
    January 01, 2012 - change depending on expert comments received on interventions issued for comment during the preceding six … the case of new applications of already- diffused technologies. … program; (2) information was compiled by November 2011 in this priority area; and (3) we received six … Results and Discussion of Comments Six experts, with clinical, research, or health systems backgrounds … of an implant.
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
    July 18, 2011 - controlled trials. 20 The tool examines six domains (sequence generation, concealment of allocation … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … for Effectiveness and Comparative Effectiveness Reviews. 29 We will examine the following four domains … each comparison, we will assign an overall evidence grade based on the ratings for the individual domains
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
    September 01, 2015 - of health care services. … of health care in the United States. … care quality. … the first four studies, the first six studies, etc.) to prepare the gradeable documents. … , indirectness, and the other domains of the grading scheme into consideration to decide what portions
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
    September 01, 2014 - Note: In addition to considering study limitations and the domains of directness, consistency, precision … Note: In addition to considering study limitations and the domains of directness, consistency, precision … six studies for this KQ, five of which were published in the year 2009 or later. … six studies … • Of 46 patients with a pathological specimen from either biopsy or surgery in the six screening studies

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