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  1. S38 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s38.pdf
    October 01, 2007 - ORIGINAL ARTICLE Design of Cluster-Randomized Trials of Quality Improvement Interventions Aimed at Medical Care Providers Robert J. Glynn, PhD, ScD, M. Alan Brookhart, PhD, Margaret Stedman, MPH, Jerry Avorn, MD, and Daniel H. Solomon, MD Background: Randomized trials aimed at improving the quality of medical care …
  2. S81 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s81.pdf
    October 01, 2007 - Of the 41 hos- pitals in the main cohort, the sensitivity analysis included 11 sites having over 100
  3. S89 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
    October 01, 2007 - groups, and (3) accommodate variation in exposed:unexposed ratios be- tween time periods and study sites … The study uses a prospective cohort design and includes all 8 VSD sites, which are geographically diverse … Data Collection All VSD sites use automated systems that track immu- nizations administered to members … In general, the seasonality of exposure was similar across the 8 VSD sites. … analysis for thrombocytopenia was lower because this outcome required laboratory data, which not all sites
  4. S123 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s123.pdf
    October 01, 2007 - ORIGINAL ARTICLE Heterogeneity and the Interpretation of Treatment Effect Estimates From Risk Adjustment and Instrumental Variable Methods John M. Brooks, PhD,* and Elizabeth A. Chrischilles, PhD† Objectives: To contrast the interpretations of treatment effect esti- mates using risk adjustment and instrumental vari…
  5. S9 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s9.pdf
    October 01, 2007 - ORIGINAL ARTICLE Medicare Part D Data Major Changes on the Horizon Leslie M. Greenwald, PhD Background: The 3 primary administrative data sets developed by the Centers for Medicare and Medicaid services (CMS) to support the Medicare Part D program implementation represent a valuable source of data for health service…
  6. S23 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
    October 01, 2007 - ORIGINAL ARTICLE Improving Depiction of Benefits and Harms Analyses of Studies of Well-Known Therapeutics and Review of High-Impact Medical Journals Artyom Sedrakyan, MD, PhD,*†‡ and Chuck Shih, MHS* Abstract: The issues of weighing benefits and harms and of shared decision-making have become increasingly important…
  7. S44 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s44.pdf
    October 01, 2007 - ORIGINAL ARTICLE Designed Delays Versus Rigorous Pragmatic Trials Lower Carat Gold Standards Can Produce Relevant Drug Evaluations Malcolm Maclure, ScD,* Bruce Carleton, PharmD,† and Sebastian Schneeweiss, MD, ScD‡§¶ Background: Centralized administrative databases enable low-cost pragmatic randomized trials (PRTs) …
  8. S50 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s50.pdf
    October 01, 2007 - ORIGINAL ARTICLE Practice-Based Evidence Study Design for Comparative Effectiveness Research Susan D. Horn, PhD, and Julie Gassaway, RN, MS Objectives: To describe a new, rigorous, comprehensive practice- based evidence for clinical practice improvement (PBE-CPI) study methodology, and compare its features, advantag…
  9. S96 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s96.pdf
    October 01, 2007 - Once data are entered at the collection sites, subsequent processing requires transmission among 3 federal … national electronic injury surveillance system-cooperative adverse drug event surveillance project—six sites
  10. S166 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s166.pdf
    October 01, 2007 - ORIGINAL ARTICLE Comparison of Meta-Analytic Results of Indirect, Direct, and Combined Comparisons of Drugs for Chronic Insomnia in Adults: A Case Study Ben W. Vandermeer, BSc, MSc, Nina Buscemi, PhD, Yuanyuan Liang, BSc, MSc, PhD and Manisha Witmans, Dip. ABSM, MD, FRCPC Background: Our Center recently conducted a…
  11. S13 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s13.pdf
    October 01, 2007 - ORIGINAL ARTICLE Methodologic Challenges to Studying Patient Safety and Comparative Effectiveness Brian L. Strom MD, MPH Abstract: Studies of patient safety and comparative effectiveness entail unique methodologic challenges. These studies may be sus- ceptible to systematic error, including selection bias, exposure …
  12. S66 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s66.pdf
    October 01, 2007 - ORIGINAL ARTICLE Assessment of Adherence to and Persistence on Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients With Rheumatoid Arthritis Carlos G. Grijalva, MD, MPH,* Cecilia P. Chung, MD, MPH,† Patrick G. Arbogast, PhD,*‡ Charles M. Stein, MD,† Edward F. Mitchel, Jr, MS,* and Marie R. Griffin, MD, MPH*§¶…
  13. S116 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s116.pdf
    October 01, 2007 - ORIGINAL ARTICLE Evaluating the Validity of an Instrumental Variable Study of Neuroleptics Can Between-Physician Differences in Prescribing Patterns Be Used to Estimate Treatment Effects? M. Alan Brookhart, PhD, Jeremy A. Rassen, MS, Philip S. Wang, MD, DrPH, Colin Dormuth, ScD, Helen Mogun, MS, and Sebastian Schnee…
  14. S149 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
    October 01, 2007 - ORIGINAL ARTICLE Using Propensity Scores Subclassification to Estimate Effects of Longitudinal Treatments An Example Using a New Diabetes Medication Jodi B. Segal, MD, MPH,* Michael Griswold, PhD,† Aristide Achy-Brou, MS,† Robert Herbert, BS,‡ Eric B. Bass, MD, MPH,*‡ Sydney M. Dy, MD,*‡ Anne E. Millman, MS,‡ Alber…
  15. S5 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
    October 01, 2007 - ORIGINAL ARTICLE Emerging Methods in Comparative Effectiveness and Safety Symposium Overview and Summary Kathleen N. Lohr, PhD Background: Interest in new methods for comparative effective- ness, drug and patient safety, and related studies is burgeoning. The advent of Medicare Part D for outpatient prescription dr…
  16. S3 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s3.pdf
    October 01, 2007 - EDITORIAL The Comparative Effectiveness and Safety Emerging Methods Symposium A Tribute to Harry A. Guess: Father and Consummate Leader of Pharmacoepidemiology David J. Ballard, MD, PhD This symposium and supplement dedicated to Harry Guess provides us with anopportunity to celebrate Harry’s life and his myriad con…
  17. S29 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s29.pdf
    October 01, 2007 - Eight sites participated. … The HMOs asso- ciated with these sites serve geographically and ethnically diverse populations with a … At some sites, more than 1 person had a given title (eg, some organizations had multiple medical directors … , we met our goal of recruiting 4 leaders; and at 3 sites, we exceeded our goal, and recruited 5 leaders … practices or sites were randomized instead of health plans?
  18. S77 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s77.pdf
    October 01, 2007 - ORIGINAL ARTICLE Out-of-Pocket Pharmacy Expenditures for Veterans Under Medicare Part D Randall W. Rupper, MD, MPH,*†‡ Byron D. Bair, MD,*‡ Brian C. Sauer, PhD,†‡ Jonathan R. Nebeker, MD, MS,*†‡ Judith Shinogle, PhD,§¶ and Matthew Samore, MD†‡ Objectives: Because the VA pharmacy benefit is deemed equivalent coverage…
  19. S131 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
    October 01, 2007 - ORIGINAL ARTICLE Increasing Levels of Restriction in Pharmacoepidemiologic Database Studies of Elderly and Comparison With Randomized Trial Results Sebastian Schneeweiss, MD, ScD,* Amanda R. Patrick, MS,* Til Stürmer, MD, MPH,* M. Alan Brookhart, PhD,* Jerry Avorn, MD,* Malcolm Maclure, ScD,* Kenneth J. Rothman, DM…
  20. S143 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
    October 01, 2007 - ORIGINAL ARTICLE Use of Propensity Score Technique to Account for Exposure-Related Covariates An Example and Lesson John D. Seeger, PharmD, DrPH,*† Tobias Kurth, MD, ScD,†‡ and Alexander M. Walker, MD, DrPH*† Background: In observational research, propensity score tech- niques can be used to account for baseline di…

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