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effectivehealthcare-admin.ahrq.gov/sites/default/files/s96.pdf
October 01, 2007 - Once data are entered at the collection sites, subsequent
processing requires transmission among 3 federal … national electronic injury surveillance system-cooperative
adverse drug event surveillance project—six sites
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s131.pdf
October 01, 2007 - ORIGINAL ARTICLE
Increasing Levels of Restriction in Pharmacoepidemiologic
Database Studies of Elderly and Comparison With
Randomized Trial Results
Sebastian Schneeweiss, MD, ScD,* Amanda R. Patrick, MS,* Til Stürmer, MD, MPH,*
M. Alan Brookhart, PhD,* Jerry Avorn, MD,* Malcolm Maclure, ScD,*
Kenneth J. Rothman, DM…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s143.pdf
October 01, 2007 - ORIGINAL ARTICLE
Use of Propensity Score Technique to Account for
Exposure-Related Covariates
An Example and Lesson
John D. Seeger, PharmD, DrPH,*† Tobias Kurth, MD, ScD,†‡
and Alexander M. Walker, MD, DrPH*†
Background: In observational research, propensity score tech-
niques can be used to account for baseline di…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s9.pdf
October 01, 2007 - ORIGINAL ARTICLE
Medicare Part D Data
Major Changes on the Horizon
Leslie M. Greenwald, PhD
Background: The 3 primary administrative data sets developed by
the Centers for Medicare and Medicaid services (CMS) to support
the Medicare Part D program implementation represent a valuable
source of data for health service…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s58.pdf
October 01, 2007 - ORIGINAL ARTICLE
Studying Prescription Drug Use and Outcomes With
Medicaid Claims Data
Strengths, Limitations, and Strategies
Stephen Crystal, PhD,*† Ayse Akincigil, PhD,*† Scott Bilder, MS,* and James T. Walkup, PhD*‡
Abstract: Medicaid claims and eligibility data, particularly when
linked to other sources of pati…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s103.pdf
October 01, 2007 - ORIGINAL ARTICLE
Using Inverse Probability-Weighted Estimators in
Comparative Effectiveness Analyses With Observational
Databases
Lesley H. Curtis, PhD,*† Bradley G. Hammill, MS,* Eric L. Eisenstein, DBA,*†
Judith M. Kramer, MD, MS,* and Kevin J. Anstrom, PhD*‡
Abstract: Inverse probability-weighted estimation is a…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s108.pdf
October 01, 2007 - ORIGINAL ARTICLE
A Simulation-Based Evaluation of Methods to Estimate
the Impact of an Adverse Event on Hospital Length of Stay
Matthew H. Samore, MD,*†‡ Shuying Shen, MS,*†‡ Tom Greene, PhD,*†‡ Greg Stoddard, MPH,*†‡
Brian Sauer, PhD,*†‡ Judith Shinogle, PhD,¶ Jonathan Nebeker, MD, MS,*†‡
and Stephan Harbarth, MD, …
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s5.pdf
October 01, 2007 - ORIGINAL ARTICLE
Emerging Methods in Comparative Effectiveness
and Safety
Symposium Overview and Summary
Kathleen N. Lohr, PhD
Background: Interest in new methods for comparative effective-
ness, drug and patient safety, and related studies is burgeoning. The
advent of Medicare Part D for outpatient prescription dr…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s29.pdf
October 01, 2007 - Eight sites participated. … The HMOs asso-
ciated with these sites serve geographically and ethnically
diverse populations with a … At some sites, more than 1 person had a given
title (eg, some organizations had multiple medical directors … , we met our goal of recruiting 4 leaders; and at 3 sites,
we exceeded our goal, and recruited 5 leaders … practices or sites were randomized instead of health plans?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s66.pdf
October 01, 2007 - ORIGINAL ARTICLE
Assessment of Adherence to and Persistence on
Disease-Modifying Antirheumatic Drugs (DMARDs) in
Patients With Rheumatoid Arthritis
Carlos G. Grijalva, MD, MPH,* Cecilia P. Chung, MD, MPH,† Patrick G. Arbogast, PhD,*‡
Charles M. Stein, MD,† Edward F. Mitchel, Jr, MS,* and Marie R. Griffin, MD, MPH*§¶…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s77.pdf
October 01, 2007 - ORIGINAL ARTICLE
Out-of-Pocket Pharmacy Expenditures for Veterans Under
Medicare Part D
Randall W. Rupper, MD, MPH,*†‡ Byron D. Bair, MD,*‡ Brian C. Sauer, PhD,†‡
Jonathan R. Nebeker, MD, MS,*†‡ Judith Shinogle, PhD,§¶ and Matthew Samore, MD†‡
Objectives: Because the VA pharmacy benefit is deemed equivalent
coverage…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s116.pdf
October 01, 2007 - ORIGINAL ARTICLE
Evaluating the Validity of an Instrumental Variable
Study of Neuroleptics
Can Between-Physician Differences in Prescribing Patterns Be
Used to Estimate Treatment Effects?
M. Alan Brookhart, PhD, Jeremy A. Rassen, MS, Philip S. Wang, MD, DrPH,
Colin Dormuth, ScD, Helen Mogun, MS, and Sebastian Schnee…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s3.pdf
October 01, 2007 - EDITORIAL
The Comparative Effectiveness and Safety Emerging
Methods Symposium
A Tribute to Harry A. Guess: Father and Consummate Leader of
Pharmacoepidemiology
David J. Ballard, MD, PhD
This symposium and supplement dedicated to Harry Guess provides us with anopportunity to celebrate Harry’s life and his myriad con…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s1.pdf
October 01, 2007 - EDITORIAL
Preface
Scott R. Smith, MSPH, PhD
The Medicare Modernization Act of 2003 (MMA) launched a new era in national healthpolicy in the United States. In addition to increasing access to outpatient prescription
medications through a new federal program, this landmark legislation creates new
opportunities and a r…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s23.pdf
October 01, 2007 - ORIGINAL ARTICLE
Improving Depiction of Benefits and Harms
Analyses of Studies of Well-Known Therapeutics and Review of
High-Impact Medical Journals
Artyom Sedrakyan, MD, PhD,*†‡ and Chuck Shih, MHS*
Abstract: The issues of weighing benefits and harms and of shared
decision-making have become increasingly important…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s38.pdf
October 01, 2007 - ORIGINAL ARTICLE
Design of Cluster-Randomized Trials of Quality
Improvement Interventions Aimed at Medical
Care Providers
Robert J. Glynn, PhD, ScD, M. Alan Brookhart, PhD, Margaret Stedman, MPH, Jerry Avorn, MD,
and Daniel H. Solomon, MD
Background: Randomized trials aimed at improving the quality of
medical care …
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s81.pdf
October 01, 2007 - Of the 41 hos-
pitals in the main cohort, the sensitivity analysis included 11
sites having over 100
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s89.pdf
October 01, 2007 - groups,
and (3) accommodate variation in exposed:unexposed ratios be-
tween time periods and study sites … The study uses a prospective cohort
design and includes all 8 VSD sites, which are geographically
diverse … Data Collection
All VSD sites use automated systems that track immu-
nizations administered to members … In general, the seasonality of exposure was similar
across the 8 VSD sites. … analysis for thrombocytopenia was lower because
this outcome required laboratory data, which not all sites
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s123.pdf
October 01, 2007 - ORIGINAL ARTICLE
Heterogeneity and the Interpretation of Treatment Effect
Estimates From Risk Adjustment and Instrumental
Variable Methods
John M. Brooks, PhD,* and Elizabeth A. Chrischilles, PhD†
Objectives: To contrast the interpretations of treatment effect esti-
mates using risk adjustment and instrumental vari…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s149.pdf
October 01, 2007 - ORIGINAL ARTICLE
Using Propensity Scores Subclassification to Estimate Effects
of Longitudinal Treatments
An Example Using a New Diabetes Medication
Jodi B. Segal, MD, MPH,* Michael Griswold, PhD,† Aristide Achy-Brou, MS,† Robert Herbert, BS,‡
Eric B. Bass, MD, MPH,*‡ Sydney M. Dy, MD,*‡ Anne E. Millman, MS,‡
Alber…