-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
June 01, 2018 - survivors, ~25% had cognitive test
scores similar to patients with mild Alzheimer’s disease.6 The severity … with
accelerated cognitive decline9 in those with pre-existing dementia, with worsening
dementia severity … control,
usual care
• Outcomes:
o Intermediate outcomes
Short-term delirium symptoms
Delirium severity … addressing
the following outcomes:
o Intermediate outcomes (short-
term delirium symptoms;
delirium severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
September 06, 2016 - While the severity of
disease varies between patients and over time in the same patient, asthma can … KQ 1.b: Ages 5 years and older with asthma (all levels of severity)
KQ 1.c: Ages 5 years and older … with asthma (all levels of severity)
KQ 1.d: Ages 5 years and older with asthma (all levels of severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-update_research-protocol.pdf
June 15, 2016 - Radiographic
evidence of OA may precede symptomatic OA but may not correlate with symptom severity. … Radiologic severity can be estimated and expressed using the Kellgren and Lawrence criteria. … population or
study characteristics: sex, disease subtype (lateral tibiofemoral, patellofemoral), severity … If possible, subgroup analysis will be conducted to assess effects of disease severity, sex,
comorbidities … Indexes of severity for osteoarthritis of the
hip and knee.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
January 01, 2014 - The clinical course,
disease progression, and severity among the
different organ systems vary markedly … The clinical course, disease
progression, and severity among the different organ
systems vary markedly … Prior to
ERT, life expectancy depended on severity of
symptoms, ranging from less than 20 years to … As stated
throughout the brief, LSD’s present in a wide range of
symptomology and severity which is … • Disease severity may dictate that treatment be initiated at a
relatively high dose or relatively
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
January 01, 2013 - do these therapies compare in different populations (e.g., different depressive diagnoses, disease severity … The effects of baseline severity,
previous treatment failure, age, gender, and
race were not sufficiently … significantly
between drug
& placebo
groups
No
differences
in AEs
between
groups
Baseline
severity … do these therapies compare in different populations (e.g., different depressive diagnoses, disease severity … The
effects
of
baseline
severity,
previous
treatment
failure,
age,
gender
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0713-140625.pdf
January 07, 2014 - other pharmacological
treatments, and all other treatment options
Outcome(s): Changes in disease severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
March 27, 2014 - b “JIA” includes any category of any severity of the following:
• JIA according to the International
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
June 23, 2014 - people with bipolar disorder,
including disease-specific characteristics such as bipolar type, phase severity … Improved social and occupational functioning
• Change in disability
• Health related quality of life
Severity … Some columns or cells may be exploded into
their own matrix, for example phase severity, again depending … Outcomes by age of onset and bipolar symptom severity
New Onset
(i.e., 1st episode)
Pediatric
onset … Late Onset
(BPVI)
Types of
Depression
Phase severity
Acute Mania
episode
--
Acute Depression
-
effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-executive-170505.pdf
May 01, 2017 - Radiographic evidence
of OA may precede symptomatic OA but
may not correlate with symptom severity. … Radiologic severity can be estimated and
expressed using the Kellgren and Lawrence
(K-L) criteria. … Adults with
Knee OA (sex,
disease subtype,
severity (stage/
pain and functional
status), fitness, … Second, published MCIDs depend on the disease
severity of the participants; the included studies often … did not report or varied widely in the disease severity of
participants.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - treatment [of patients diagnosed with OSA]), specifically for
patients with mild-to-moderate disease severity … questionnaires: STOP, STOP-Bang, ASA
checklist, Hawaii Sleep Questionnaire.
1IC3: No tests based on severity … bias.
2D2: Studies evaluating the appropriateness of tests
based on patient characteristics and severity … treatments of patients diagnosed with OSA), specifically for patients with mild to moderate disease severity … bias.
2D2: Studies evaluating the appropriateness of tests
based on patient characteristics and severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - consistent
but imprecise effects on disease severity measured through a
range of specific outcomes … Overall, intervention A reduced the severity
of [disease] more than intervention B
Low
(improved … We use “Severity of
[Disease],”as presented in Table 5, as the outcome example for these tables and … Other concerns: None
Intervention A reduced the severity of [disease] more than intervention B. … Strength of Evidence for Severity of Disease
Of eight trials initially addressing the comparison of
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - 75%
Hispanic: 19%
Other: 7% Pain duration: 110 months
Baseline pain intensity, BPI (0-10): 6, CGI-severity
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
April 15, 2021 - It may be worth
specifying that “disease severity” refers to the severity
of the mental health disorder … We added some text regarding lack of
control for severity. … ” refers to the severity of
psychiatric illness or other physical health conditions. … The text now says: “Four
of the six studies did not account for
severity of psychiatric illness.” … The bullet point that
begins “For reduction in depression severity...” is
confusing as written.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
February 05, 2025 - suggestions on evaluating outcomes by the timing of occurrence
and specific scales used to measure the severity … self-harm
with suicidal intent, self-harm without suicidal intent)
• Suicidal ideation
• Measures of severity … Conference abstracts
Abbreviations: ASQ = Ask Suicide-Screening Questions; C-SSRS = Columbia Suicide Severity … for Healthcare Research and Quality
ASQ Ask Suicide-Screening Questions
C-SSRS Columbia Suicide Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - Extracted, comparable THC to CBD ratio oral spray is probably associated with
small improvements in pain severity … • Synthetic and purified THC (high THC to CBD) may be associated with small
improvement in pain severity … weeks to <6 months)
Product, THC to CBD Ratio
Pain Responsea
Effect Size (N Studies)
[SOE]
Pain Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
December 31, 2022 - by patient
characteristics (e.g., age, gender,
race/ethnicity, and comorbidities), COVID-
19 disease severity … vary by factors
such as initial antibody levels, patient
characteristics, presence of symptoms, or
severity … identification
method (e.g., surveillance, symptomatic
testing only), presence of symptoms, or
COVID-19 severity … patient
characteristics (e.g., age, gender, race/ethnicity, and comorbidities), COVID-19
disease severity … Rate and
severity of suspected SARS-Cov-2 reinfection in
a cohort of PCR-positive COVID-19 patients
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - • Comparable THC to CBD ratio oral spray is probably associated with small
improvements in pain severity … • Synthetic THC (high-THC to CBD) may be associated with moderate
improvement in pain severity, but … weeks to <6 months)
Product, THC to CBD Ratio
Pain Response
Effect Size (N Studies)
[SOE]
Pain Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - to patient subgroup characteristics, including but not limited to HCV genotype, race, sex, disease
severity … to patient subgroup characteristics, including but not limited to HCV genotype, race,
sex, disease severity … differ according to patient subgroup characteristics, including HCV genotype,
race, sex, disease severity … to patient subgroup characteristics, including but not
limited to HCV genotype, race, sex, disease severity … to patient subgroup characteristics,
including but not limited to HCV genotype, race, sex, disease severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - to patient subgroup characteristics, including but not limited to HCV genotype, race, sex, disease
severity … to patient subgroup characteristics, including but not limited to HCV genotype, race,
sex, disease severity … differ according to patient subgroup characteristics, including HCV genotype,
race, sex, disease severity … to patient subgroup characteristics, including but not
limited to HCV genotype, race, sex, disease severity … to patient subgroup characteristics,
including but not limited to HCV genotype, race, sex, disease severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
January 01, 2017 - supportive care (including pharmacologic—antibiotic or
non-antibiotic—treatments) on the number and severity … The clinical
significance of this improvement is likely influenced by
baseline disease severity and … Baseline severity of OSDB or throat infection varied
across these studies as did definitions of “cure … Future studies should take more care to characterize
patient populations completely—including severity … Similarly, studies also typically did not clearly
characterize severity of PTH, and many did not clearly