-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - Are certain patient characteristics (such as iron deficiency, disease duration, severity)
more highly … Does treatment efficacy differ by RLS symptom severity?
13. … I
4 Are certain patient characteristics (iron deficiency or disease duration or severity more highly … I
2 Does treatment efficacy differ by RLS symptom severity? … • Does treatment efficacy differ by RLS symptom severity?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
January 31, 2013 - PAD represents a spectrum of disease severity, encompassing both asymptomatic and
symptomatic disease … In 5 to 10 percent of
cases, claudication progresses to a worsened severity of the disease, called critical … Classification Schemes
While ABI measurements may quantify PAD severity, the ABI represents a numerical … value
that does not provide clinicians a full picture of the clinical severity of the disease. … There are two
classification systems, Rutherford and Fontaine,2 used by clinicians to grade the severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lumbar-fusion-protocol.pdf
June 20, 2024 - iatrogenic neurological events); and (5) how population characteristics and
differences (e.g., age, severity … , presence and type of concomitant degenerative
lumbar spine disease, and degree (grade, severity) of … sex, BMI, presence of
psychological comorbidities, presence of medical comorbidities, baseline pain severity … , presence
and type of concomitant degenerative lumbar spine disease, presence and severity of DLS. … by study quality, study design, intervention differences,
patient characteristics (e.g., age, sex), severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_research-protocol.pdf
September 20, 2013 - The manifestation and severity of symptoms of ASD differs
widely, and treatments include a range of … aimed at
modifying
ASD
symptoms
Placebo, other
intervention, or
no intervention
• ASD symptom severity … aimed at
modifying
ASD
symptoms
Placebo, other
intervention, or
no intervention
• ASD symptom severity … Target outcomes in the
treatment setting include ASD symptom severity, language/ communication, academic … identify subgroups, which may include different age groups, severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
July 01, 2011 - Does the comparative effect of treatments vary
based on presenting patient characteristics,
severity … Does the comparative effect of treatments vary
based on presenting patient characteristics,
severity … Studies of
appropriate tests for patients, based on the type or
severity of their symptoms, would be … Predictors of Clinical Outcomes and
Compliance
• The question of whether OSA severity is associated … , presence of
Other treatments for others) comorbidities, and severity of obesity.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
March 07, 2021 - Infants (1 month to <3 years) diagnosed with
epilepsy
• Subpopulations based on baseline seizure
severity … Hospitalization
3
Inclusion Exclusion
• Seizure freedom
• Seizure frequency
• Seizure severity … Outcomes:
• All-cause mortality
• SUDEP
• Hospitalization
• Seizure freedom
• Seizure frequency
• Seizure severity … Subpopulations
based on
baseline seizure
severity/frequen
cy, history of
previous
treatment, length … of gestation
Subpopula
tions
based on
baseline
seizure
severity/fr
equency,
history of
previous
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
December 01, 2011 - CDI symptoms include varying levels of
diarrhea severity, as well as
pseudomembranous colitis and toxic … The immune status of
the patient also contributes to the risk of developing
CDI and the experienced severity … (a) Does effectiveness vary by disease severity or
strain? … One subgroup analysis of a
single trial used a prespecified analysis, and the severity
classification … A well-validated and
clinically meaningful severity score would also assist in
treatment decisions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_disposition-comments.pdf
August 16, 2016 - These moderate lesions must have
hemodynamic confirmation of their severity to merit
revascularzation … CORAL is in the
process of publishing BP data stratified by severity of
stenosis, baseline SBP, and … "High likelihood of poor outcomes": Might
elaborate on this more, including such variables as CHF
severity … exceeds the core lab determined stenosis severity. … CORAL reports on pulmonary edema or
CHF, as we report, though not recurrent or
severity.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-disease-medicine_research-protocol.pdf
November 01, 2010 - Further, there appears to be a graded relationship between the severity of
proteinuria or albuminuria … • How do patient factors, CKD severity/stage, and CKD monitoring intervals modify
the association of … • How do patient factors, CKD severity/stage, and CKD monitoring intervals modify
the association of … • How do patient factors and CKD severity/stage modify the association of CKD
treatment with harms? … will be
examined overall and, where possible, stratified by patient CKD risk factors, baseline
CKD severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
September 14, 2016 - While the
severity of disease varies between patients and over time in the same patient, asthma can … the categories: 0-4 years old, 5-11 years old and older than 12 years old1
o Grouping by asthma severity … data on subgroups of interest, including gender, age, ethnicity, asthma definition,
asthma status and severity … Factors that may limit
applicability include age, asthma severity or poorly controlled asthma, type … It can be used to diagnose asthma, characterize the severity of asthma, and/or
assess the patient's
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
May 01, 2016 - Severity
Grading
DSM-IV does not include a BED severity grading scale. … Applicable to DSM-5 only, BED severity is graded as follows:
�� Mild: 1 to 3 episodes per week
�� Moderate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
December 14, 2017 - Also, if there
are any data regarding their ages at diagnosis, symptom
severity, and estimated time … Scale Does Not Measure the Variability and Severity of
Menses. … Revision
reads: The Symptom Severity Scale assesses severity of fibroid
related symptoms (including … In fact, the intent
of the Symptom Severity Scale is not to measure the “variability
and severity of … It measures the
“distress due to the frequency and severity of uterine
leimyomata symptoms”.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Pain severity for fibroyalgia
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 … Pain severity for osteoarthiritis
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Pain severity for low back pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
January 01, 2025 - suggestions on evaluating outcomes by the timing of occurrence
and specific scales used to measure the severity … self-harm
with suicidal intent, self-harm without suicidal intent)
• Suicidal ideation
• Measures of severity … Conference abstracts
Abbreviations: ASQ = Ask Suicide-Screening Questions; C-SSRS = Columbia Suicide Severity … for Healthcare Research and Quality
ASQ Ask Suicide-Screening Questions
C-SSRS Columbia Suicide Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/psoriasis-chronic_research-protocol.pdf
January 10, 2012 - affect the genitals, nails, palms, and soles of the feet.
4,5
Different parameters determine disease
severity … The Psoriasis Area and Severity Index (PASI)
score will be considered not only as a binary outcome … Although we had proposed the Psoriasis Scalp Severity Index (PSSI) and the Nail Psoriasis
Severity … which patient or disease characteristics (e.g., age, gender,
race, weight, smoking status, psoriasis severity … , presence or absence of concomitant psoriatic
arthritis, disease duration, baseline disease severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - plant-extracted THC to CBD ratio oral spray is probably associated
with small improvements in pain severity … • Synthetic THC (high-THC to CBD) may be associated with small improvement in
pain severity, but … weeks to <6 months)
Product, THC to CBD Ratio
Pain Responsea
Effect Size (N Studies)
[SOE]
Pain Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
March 14, 2024 - suggestions on evaluating outcomes by the timing of occurrence
and specific scales used to measure the severity … self-harm
with suicidal intent, self-harm without suicidal intent)
• Suicidal ideation
• Measures of severity … Conference abstracts
Abbreviations: ASQ = Ask Suicide-Screening Questions; C-SSRS = Columbia Suicide Severity … for Healthcare Research and Quality
ASQ Ask Suicide-Screening Questions
C-SSRS Columbia Suicide Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - The stress of pregnancy and imminent infant care may exacerbate the frequency and/or severity
of primary … the mother, the fetus/child, and mother-child bonding.8 Outside of pregnancy, migraine
frequency and severity … headache attacks*
o Occurrence of acute headache attacks
o Frequency of acute headache attacks
o Severity … dizziness)*
o Occurrence of headache-related symptoms
o Frequency of headache-related symptoms
o Severity … of acute headache attack
• Headache-related symptoms (e.g., nausea/vomiting, photosensitivity)*
o Severity
-
effectivehealthcare.ahrq.gov/sites/default/files/Evidence%20Summary_1.pdf
April 01, 2020 - We also
found few trials that stratified results by CATD
severity. … Because we analyzed studies grouped by
participant CATD severity and graded SOE for
treatment effects … within these severity categories,
it is possible that SOE grades would have been
different in cases … when lumping studies regardless
of baseline CATD severity may have been
clinically reasonable (e.g … , baseline BPSD severity, and living setting.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
February 01, 2019 - different
doses, or treatment durations (comparative effectiveness)
Outcomes:
• KQ 1: Pain (intensity, severity … 6
PICOTS Include Exclude
Outcomes • Pain (intensity, severity … classified as small/slight might vary for individual patients depending on
preferences, baseline symptom severity … priori include eligibility criteria and patient factors (e.g.,
demographic characteristics, duration or severity … underlying pain condition, presence of
medical and psychiatric comorbidities, event rates and symptom severity