-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final.pdf
February 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final_0.pdf
March 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final_0_0.pdf
March 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-jan-2020.pdf
January 01, 2020 - Specific adverse events of dizziness (mean, 32% vs. 9.5%), nausea (32%
vs. 6%), and sedation (7% vs. … 10%).17 The 3-week trial and the 52-week cohort study also
reported higher incidences of nausea and sedation … At 6 months, more patients in the gabapentin group reported sedation
(60%) than in the other two groups … greater with
THC/CBD (4 RCTs)
Dizziness, nausea,
sedation greater with THC
(2 RCTs, 1 cohort study … )
Dizziness, sedation greater
with THC vs. placebo (1
RCT)
Abbreviations: AE = adverse event; CBD
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cer-250-cannabis-apps-a-e-surveillance-report-2.pdf
January 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cer-250-cannabis-apps-a-e-surveillance-report-2-final.pdf
March 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
December 16, 2011 - Mirapex
®
Yes
Ritigotine Neupro
®
Sedative-
hypnotics
Clonazepam Rivotril
®
Tolerance; sedation … Gabapentin Neurontin
®
Pregabalin Lyrica
®
Opioids Hydrocodone -Vicodin
®
-Lortab
®
Sedation
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/in-patients-with-dementia-what-is-the-effectiveness-of-psychological-treatment-ie-non-pharmacological-eg-cognitive-or-behavioral-therapy-for-individuals-with-dementia-environmental-and-behavioral-interventions-to-address-beha
March 07, 2013 - Weight gain, sedation, mortality associated with off-label use of atypical antipsychotics in dementia
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plant-based-chronic-pain-review-q2.pdf
May 01, 2021 - Specific adverse events of dizziness, nausea, and sedation were most frequently reported
and occurred … greater with THC/CBD (4 RCTs)
Dizziness, nausea, sedation
greater with THC/CBD
Abbreviations: … groups (2 RCTs)
0 WAEs, other outcomes not
reported
Specific Adverse Events Dizziness, nausea, sedation … greater with THC (2 RCTs, 1
cohort study)
Dizziness, sedation greater with
THC
Abbreviations: … greater with
THC vs. placebo (1 RCT)
Sedation greater with THC vs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-annual-update2-table-e5.xlsx
March 13, 2023 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-app-F-5.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-table-F5.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-treatments-chronic-pain.pdf
December 01, 2021 - amitriptyline
• SOE: Insufficient based
on 1 RCT
1 new RCT (n=70) found no
increase in SAE, nausea, or
sedation … increase in cognitive AEs
• SOE: Low based on 8
RCTs
Large increase in dizziness,
peripheral edema, sedation … oral THC/CBD
associated in large increase in
WAEs, dizziness, nausea, but no
increase in SAEs or sedation
-
effectivehealthcare.ahrq.gov/products/autism-update/clinician
September 23, 2014 - evidence insufficient]
Harms
Aripiprazole and risperidone are associated with significant weight gain, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_clinician.pdf
September 01, 2014 - .
Harms
� Aripiprazole and risperidone are associated with significant weight
gain, sedation,
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plant-based-chronic-pain-review-q3.pdf
September 01, 2021 - There may
be a large increased risk of dizziness and sedation, and a moderate increased risk of
nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … Studies)
SOE
Dizziness
Effect Size (N
Studies)
SOE
Nausea
Effect Size (N
Studies)
SOE
Sedation … Combined THC/CBD may also be associated with a
moderate to large increased risk of dizziness, sedation … Placebo
Sedation 6 RCTs
(N=866)1,2,4-7
Moderate Direct Consistent Imprecise Unknown Large effect
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorder_executive.pdf
October 01, 2015 - this report, frequently
occurring adverse events associated with risperidone
included weight gain, sedation … Sedation was the most frequently reported harm in a study
comparing aripiprazole (sedation occurring … in 50% of
children) and ziprasidone (sedation occurring in 57% of
children), while harms were generally … Adverse events
associated with risperidone were generally mild across
studies, with weight gain, sedation … Sedation was frequently reported with
aripiprazole and ziprasidone.
-
effectivehealthcare.ahrq.gov/sites/default/files/Disposition%20of%20Comments.pdf
September 03, 2019 - review SPECIFICALLY
involves antipsychotics for delirium, and NOT for other
potential uses such as sedation … Public Reviewer
#1 (Medicus,
Jennifer [APA])
Results Page 29, sedation haloperidol v placebo – in … The absence of sedation with a given
treatment is, in fact, important to know when assessing
the potential … It is precisely
because of the rare events in relation to sedation that
we have been unable to come
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Disposition%20of%20Comments.pdf
September 03, 2019 - review SPECIFICALLY
involves antipsychotics for delirium, and NOT for other
potential uses such as sedation … Public Reviewer
#1 (Medicus,
Jennifer [APA])
Results Page 29, sedation haloperidol v placebo – in … The absence of sedation with a given
treatment is, in fact, important to know when assessing
the potential … It is precisely
because of the rare events in relation to sedation that
we have been unable to come
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
September 03, 2019 - review SPECIFICALLY
involves antipsychotics for delirium, and NOT for other
potential uses such as sedation … Public Reviewer
#1 (Medicus,
Jennifer [APA])
Results Page 29, sedation haloperidol v placebo – in … The absence of sedation with a given
treatment is, in fact, important to know when assessing
the potential … It is precisely
because of the rare events in relation to sedation that
we have been unable to come