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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0215_01-06-2010.pdf
January 01, 2010 - Effective Health Care
Topic Number(s): 0239
Document Completion Date: 8-13-10
1
Results of Topic Selection Process & Next Steps
Treatment of restless legs syndrome will go forward for refinement as a systematic review. The scope
of this topic, including populations, interventions, comparato…
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Primary: efficacy outcomes (i.e., pain, overall function, adverse effects (e.g., dizziness, nausea, sedation … Size (N Studies)
[SOE]a Dizziness
Effect Size (N Studies)
[SOE]a Nausea
Effect Size (N Studies)
[SOE]a Sedation … Cannabis products associated with increased risk of adverse events (dizziness, sedation, nausea); studies
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-table-e5-2022-update_0.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/preoperative-testing_research-protocol.pdf
May 14, 2013 - surgical
or
other
invasive
procedure
that
commonly
requires
anesthesia
or
sedation … will
be
included
regardless
of
local
practice
regarding
anesthesia
or
sedation … undergoing
nonsurgical
diagnostic
procedures
that
may
require
anesthesia
or
sedation … routine preoperative testing in patients
undergoing surgery or procedures requiring anesthesia or sedation—administered … to explore differences across:
• Types of and indications for surgery
• Types of anesthesia or sedation
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effectivehealthcare.ahrq.gov/sites/default/files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - events, such
as vomiting and subsequent airway
obstruction, respiratory depression,
hypotension, and sedation … at 15 min.
dInsufficient for drowsiness, changes in RAAS, reduced GCS, sleepiness/tired, confusion, sedation … , difficulty
concentrating.
eFor dizziness, sedation.
fInconclusive for mild sedation.
gFor dizziness
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - events, such
as vomiting and subsequent airway
obstruction, respiratory depression,
hypotension, and sedation … at 15 min.
dInsufficient for drowsiness, changes in RAAS, reduced GCS, sleepiness/tired, confusion, sedation … , difficulty
concentrating.
eFor dizziness, sedation.
fInconclusive for mild sedation.
gFor dizziness
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effectivehealthcare.ahrq.gov/products/migraine-emergency/research-protocol
July 18, 2011 - Addressing sedation as an adverse event.
The followup period for longer term outcome studies. … regular activities
Patient satisfaction with experience
Adverse effects of intervention(s)
Sedation … satisfaction with experience
Quality of life/return to activities
Adverse effects of intervention(s):
Sedation … in the ED, Visual Analog Scale score at discharge, and relapse after 48 hours) and safety (e.g., sedation … Agents for procedural sedation
Ketamine 1
Ketalar
IV, IM
Ketofol
NA
IV
Propofol
Diprivan
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effectivehealthcare.ahrq.gov/products/suicide-prevention/research-protocol
December 28, 2015 - Current Page Topic Timeline Sep. 18, 2015 Topic Initiated Dec. 28, 2015 Research Protocol Oct. 4, 2016 Systematic Review Feb. 9, 2017 Disposition of Comments Report Suicide Prevention
Research Protocol Archived December 28, 2015 Download Main Document PDF 1.3 MB
Archived: This report is greater than …
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
December 23, 2015 - Untitled
Source: www.effectivehealthcare.ahrq.gov
Published online: December 23, 2015
Evidence-based Practice Center Systematic Review Protocol
Project Title: Suicide Prevention
I. Background and Objectives for the Systematic Review
Despite advances in the diagnosis and treatment of major mental disord…
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effectivehealthcare.ahrq.gov/sites/default/files/fraenkel.pdf
December 26, 2012 - http://www.effectivehealthcare.ahrq.gov/index.cfm) �
• Sedation
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
November 01, 2012 - acute migraine
Intervention Generic Name Trade Name(s) Mode of Administration
Agents for Procedural
Sedation … The results are presented by adverse
effect categories (e.g., sedation, dizziness, vomiting). … Sedation/Somnolence
Twenty-five studies reported on the development of
sedation/somnolence, including … The risk of developing sedation/
somnolence as a result of taking a placebo was 5 percent
(95% CI, 2 … The risk of
experiencing sedation following administration of
metoclopramide and prochlorperazine was
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-appendix-b.xlsx
January 08, 2024 - anticipated to be in the ICU for more than 48 hours; 2) Patients who had had any procedure(s) that required sedation … positive on the Confusion Assessment Method in the ICU tool; (4) Patients who had a Richmond Agitation-Sedation
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effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Duloxetine resulted in a large, dose-
dependent, increase in sedation (SOE: Moderate to
Low). … Additionally, pregabalin resulted in large increases
in risk of peripheral edema and sedation (SOE: … Duloxetine also resulted in increased sedation, but
lower doses did reduce the risk. … and
gabapentin resulted in moderate to large increases
in blurred vision, dizziness, weight gain, sedation … Additionally, pregabalin resulted in large
increases in risk of peripheral edema and sedation.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
July 18, 2011 - Addressing sedation as an adverse event. … Sedation/somnolence
b. Dizziness
c. Restless legs/akathisia
d. Anxiety
e. Vomiting
f. … Sedation/somnolence
2. Dizziness
3. Restless legs/akathisia
4. Anxiety
5. Vomiting
6. … in the ED, Visual Analog Scale score at discharge, and relapse after 48 hours)
and safety (e.g., sedation … interventions for acute migraine
Generic name Trade name(s) Mode of administration
Agents for procedural sedation
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_executive.pdf
August 01, 2013 - characteristics,
and symptoms
Comparative e�ectiveness of
treatment interventions
Worsening of tinnitus
Sedation … subjective loudness, quality of life, tinnitus severity, adverse effects (worsening
of tinnitus, sedation … subjective loudness, quality of life, return
to “normal” work, adverse effects (worsening of tinnitus, sedation … The findings for sedation were inconsistent
and imprecise, as estimates of affected patients were
poorly … characterized; the SOE for sedation was insufficient
in patients with tinnitus.
7
Table B.
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effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - FGAs are mainly
associated with dry mouth, sedation, and
extrapyramidal symptoms, which are
movement … cause
adverse effects including weight
gain, high triglyceride levels,
extrapyramidal symptoms, sedation … There may
be little or no difference between classes for sedation. … • Sedation. … There may be little or no difference between
olanzapine and risperidone for risk of sedation.
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effectivehealthcare.ahrq.gov/products/restless-legs/research-protocol
December 16, 2011 - Ritigotine
Neupro®
Sedative-hypnotics
Clonazepam
Rivotril®
Tolerance; sedation … Pregabalin
Lyrica®
Opioids
Hydrocodone
-Vicodin® -Lortab®
Sedation
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effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-endotracheal-intubation.pdf
January 26, 2021 - states,
approximately 230 million major surgical procedures, typically requiring general anesthesia or
sedation
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effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
April 15, 2021 - In discussing the potential for adverse effects
with brexanolone, sedation and loss of consciousness
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2.pdf
January 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … high THC to CBD) may be associated with moderate improvement in
pain severity and increased risk of sedation … no effect
on overall function/disability
(SOE: low; 2 RCTs)
Harms: moderate increased risk
of sedation … Combined THC/CBD may also be associated
with a moderate to large increased risk of dizziness, sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup)