-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_clinician.pdf
August 01, 2017 - people with
primary depression
�� Severe anaphylactic or anaphylactoid reactions
�� Possible profound sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
June 15, 2010 - Treatment emergent symptoms as follows: Sexual dysfunction symptoms,
Neuropsychiatric symptoms or sedation … Treatment emergent symptoms as follows: Sexual dysfunction symptoms,
Neuropsychiatric symptoms or sedation … Treatment emergent symptoms as follows: Sexual dysfunction symptoms,
Neuropsychiatric symptoms or sedation … Treatment emergent symptoms as follows: Sexual dysfunction symptoms,
Neuropsychiatric symptoms or sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
May 01, 2022 - There may be a large increased risk of
dizziness and sedation, and a moderate increased risk of nausea … THC to CBD ratio) may be associated with moderate improvement
in pain severity and increased risk of sedation … Sedation for comparable THC to CBD ratio versus placebo (short-term, 4 weeks to 6 months followup) … Sedation for high THC versus placebo (short-term, 4 weeks to 6 months followup)
Abbreviations: CI … Placebo
Sedation 3 RCTs (N=335)9-
11
Moderate Direct Consistent Imprecise Unknown Moderate effect
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-tables-F1-4.xlsx
January 01, 2022 - (Numerator) Intervention A, N Analyzed for Sedation (Denominator) Intervention A, % With Sedation Intervention … B, N With Sedation (Numerator) Intervention B, N Analyzed for Sedation (Denominator) Intervention B … , % With Sedation Intervention C, N With Sedation (Numerator) Intervention C, N Analyzed for Sedation … (Denominator) Intervention C, % With Sedation Intervention D, N With Sedation (Numerator) Intervention … D, N Analyzed for Sedation (Denominator) Intervention D, % With Sedation Intervention A, N of Cannabis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
November 27, 2012 - Commentator
& Affiliation
Section Comment Response
Peer Reviewer
#4
Structured abstract "The risk of sedation … the following information from the abstract for both
metoclopromide and neuroleptics:
"The risk of sedation … The risk of sedation is from the
side effects section under both agents, and the
reference to the 10 … The most common side effects were skin and local reactions,
sedation, digestive problems, nausea or … reestablish the homeostasis needed to abort an attack. no one
has looked to low dose ketamine followed by sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
July 01, 2012 - Peer Reviewer 3 Introduction I recommend adding that NPPV does not require moderate sedation
(instead … of only “deep” sedation) Page ES-2, line 26: add “moderate
and/or” just prior to “…deep sedation” … Page 3, line 39: add “moderate and/or” just prior to “…deep sedation”
The text has been modified to … specify “moderate
and/or deep sedation.”
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
April 01, 2013 - In one RCT, dosing of sedation (light vs. deep) in critically
ill patients did not affect posttraumatic … Robbery victims29
PTSD symptom severity Inconclusive, single trial (N=77) Insufficient
Pharmacological sedation … trial (N=236), inconsistent findings at different
assessment intervals
Insufficient
Pharmacological sedation … One randomized open-label trial considered comparative
risk of harms from light versus deep sedation … Randomized trial of
light versus deep sedation on mental health after critical illness.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
September 03, 2019 - review SPECIFICALLY
involves antipsychotics for delirium, and NOT for other
potential uses such as sedation … Public Reviewer
#1 (Medicus,
Jennifer [APA])
Results Page 29, sedation haloperidol v placebo – in … The absence of sedation with a given
treatment is, in fact, important to know when assessing
the potential … It is precisely
because of the rare events in relation to sedation that
we have been unable to come
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - In the CATIE trial, risperidone, quetiapine, and
olanzapine were each more likely to cause
sedation than … Odds were also higher for
gastrointestinal problems, increased salivation,
fatigue, EPS, and sedation … Compared to placebo, all atypicals were associated
with sedation in multiple pooled analyses for all
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-F.xlsx
January 01, 2023 - (Numerator) Intervention A, N Analyzed for Sedation (Denominator) Intervention A, % With Sedation Intervention … B, N With Sedation (Numerator) Intervention B, N Analyzed for Sedation (Denominator) Intervention B … , % With Sedation Intervention C, N With Sedation (Numerator) Intervention C, N Analyzed for Sedation … (Denominator) Intervention C, % With Sedation Intervention D, N With Sedation (Numerator) Intervention … D, N Analyzed for Sedation (Denominator) Intervention D, % With Sedation Intervention A, N of Cannabis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-E-1-E-4.xlsx
January 01, 2023 - (Numerator) Intervention A, N Analyzed for Sedation (Denominator) Intervention A, % With Sedation Intervention … B, N With Sedation (Numerator) Intervention B, N Analyzed for Sedation (Denominator) Intervention B … , % With Sedation Intervention C, N With Sedation (Numerator) Intervention C, N Analyzed for Sedation … (Denominator) Intervention C, % With Sedation Intervention D, N With Sedation (Numerator) Intervention … D, N Analyzed for Sedation (Denominator) Intervention D, % With Sedation Intervention A, N of Cannabis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-F1-4.xlsx
January 01, 2022 - (Numerator) Intervention A, N Analyzed for Sedation (Denominator) Intervention A, % With Sedation Intervention … B, N With Sedation (Numerator) Intervention B, N Analyzed for Sedation (Denominator) Intervention B … , % With Sedation Intervention C, N With Sedation (Numerator) Intervention C, N Analyzed for Sedation … (Denominator) Intervention C, % With Sedation Intervention D, N With Sedation (Numerator) Intervention … D, N Analyzed for Sedation (Denominator) Intervention D, % With Sedation Intervention A, N of Cannabis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
October 01, 2016 - psychiatrically ill, violently
agitated patients requiring chemical restraint produced
more rapid sedation … and greater sedation overall than
intramuscular lorazepam68 (one RCT, insufficient SOE). … other medication
protocols:
Benefits
(continued)
Change in
aggressive
behavior
(continued)
Sedation … Another RCT reported on acute extrapyramidal
events and incidence of marked sedation in a comparison … flunitrazepam at 90 minutes.48
Marked sedation
28
Insufficient Medium risk of
bias, consistency
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Computer-assisted system (Sedasys) for propofol sedation during
gastrointestinal endoscopy procedures … Computer-assisted system (Sedasys) for propofol sedation during gastrointestinal
endoscopy procedures … system intended
to aid clinicians in delivering propofol for minimal to moderate sedation during routine … The Sedasys sedation system is
intended to allow teams led by physicians who are not anesthesiologists … expressed views that
the Sedasys system does not address a significant unmet need because alternative sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
May 19, 2020 - rate
• Blood pressure
• Objective measure of exercise capacity, e.g., 6-minute walk test
• Level of sedation … bicarbonate levels
• Heart rate
• Blood pressure
• Objective measure of exercise
capacity
• Level of sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-table-E-5.xlsx
January 01, 2023 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-table-F5.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
February 15, 2017 - Other risks: akathisia, restlessness, sedation,
headache, nausea and vomiting
Olanzapine6 For bipolar … safety alert: DRESS (drug reaction
with eosinophilia and systemic symptoms)
FDA black box: delirium/sedation … syndrome with long acting injection (likely
not relevant to use in depression)
Other risks: akathisia, sedation … Quetiapine7 Yes, as an
adjunct with an
antidepressant
Other risks: sedation, hypertension,
cataracts … but not limited to
constipation, urinary retention and blurred vision) and CNS depression including
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
March 14, 2012 - procedure, a manometry catheter is inserted into the pyloric channel with endoscopic guidance
and sedation … motility capsule include that it is
wireless and painless, can be used in an office setting without sedation … The catheter is left in place in some
cases for up to 24 hours, and recordings are obtained after sedation … would capture the number of hours without
anything by mouth before the procedure and the method of sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
December 01, 2010 - terms of extrapyramidal side effects and tardive dyskinesia, but produce other side
effects, including sedation … General: extrapyramidal side effects, weight gain, agitation, constipation,
sedation, elevated cholesterol … behaviors, death by suicide
General: extrapyramidal effects, weight
gain, agitation, constipation, sedation … • General adverse events: extrapyramidal effects, weight gain, agitation,
constipation, sedation,