-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
February 01, 2008 - Potentiate
GABA
receptor
function
Absence
Atypical
Absence
Myoclonic
Neurological: ataxia,
sedation … and increase
GABA
availability
Partial
Lennox-
Gastaut
Neurological: insomnia,
dizziness, sedation … Tonic-
Clonic
Atypical
Absence
Myoclonic
Lennox-
Gastaut
Neurological: dizziness,
diplopia, sedation … Yes
Phenobarbital Potentiate
GABA
receptor
function
Partial
Tonic-
Clonic
Neurological: sedation … No
Tiagabine Increase
GABA
availability
Partial
Tonic-
Clonic
Neurological: confusion,
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-q3-tables-f5.xlsx
June 15, 2021 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0775-150722.pdf
May 12, 2015 - medications, such as Parkinsonism, akathisia, dystonia, and tardive dyskinesia), prolactin elevation,
sedation … medication (e.g., diabetes mellitus, extrapyramidal symptoms / tardive dyskinesia,
prolactin elevation, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - There may be a large increased risk of dizziness and sedation and a moderate
increased risk of nausea … high-THC to CBD) may be associated with moderate
improvement in pain severity, but with increased risk of sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … the results with recent systematic reviews
that used the same methodology, suggests that the risk of sedation … placebo, these interventions resulted in greater risk of common adverse events (dizziness,
nausea, sedation
-
effectivehealthcare.ahrq.gov/products/tinnitus/research
August 23, 2013 - The SOE for the adverse effect of sedation in pharmacological studies was judged insufficient.
-
effectivehealthcare.ahrq.gov/products/preoperative-testing/research
January 29, 2014 - of both adults and children undergoing surgical and other procedures requiring either anesthesia or sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2.xlsx
January 22, 2022 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5.xlsx
November 04, 2021 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0.xlsx
February 16, 2022 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
April 01, 2021 - • Brexanolone probably improves depressive symptoms; it may increase the risk of
sedation or somnolence … in the third trimester or within 4 weeks
of birth, brexanolone may be associated with the risk of sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
February 16, 2022 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
November 04, 2021 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Consistent with prior
evidence, gabapentin was associated with increased risk of dizziness, sedation … in
cognitive AEs
• SOE: Low. based
on 8 RCTs
Large increase in
dizziness, peripheral
edema, sedation … (n=366) found
increased risk of
dizziness.6,7,9
1 RCT (n=306) found
increased risk of SAEs,
sedation … THC/CBD
associated with large
increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … SOE for large increase in risk for cognitive effects, moderate SOE for large increase in risk for
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Consistent with prior
evidence, gabapentin was associated with increased risk of dizziness, sedation … in
cognitive AEs
• SOE: Low. based
on 8 RCTs
Large increase in
dizziness, peripheral
edema, sedation … (n=366) found
increased risk of
dizziness.6,7,9
1 RCT (n=306) found
increased risk of SAEs,
sedation … THC/CBD
associated with large
increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … SOE for large increase in risk for cognitive effects, moderate SOE for large increase in risk for
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - Other common side effects are
dry mouth and sedation. … Patient-, parent- or care
impressions symptoms side effects provider-reported
outcomes
Depression Tics Sedation … difference.
sexual AE (1 RCT, 1 PCS)
Haloperidol vs. risperidone Low No significant difference.
(2 RCTs)
Sedation … SGA (continued)
Sedation Clozapine vs. olanzapine Low No significant difference.
(1 RCT, 1 PCS, 1 RCS … Sedation Aripiprazole vs. placebo (4 RCTs) Low Significant effect in favor of placebo
(RR = 2.7, 95%
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pbt-lsr-draft-ets-obs.xlsx
March 15, 2022 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
July 01, 2022 - from
Surveillance Report 2 found
increased risk of WAEs and
nonsignificantly increased
risk of sedation … 95% CI,
1.88 to 5.34, I2=0%)
• Dizziness (28 RCTs): RR
2.85 (95% CI, 2.43 to
3.34, I2=36%)
• Sedation … THC/CBD associated with
large increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … 4.48 (95% CI, 2.77 to
7.22, I2=0%)
• Nausea (2 RCTs): RR
2.11 (95% CI, 1.20 to
3.72, I2=0%)
• Sedation … Gabapentin/pregabalin harms, sedation
Abbreviations: CI=confidence interval; CPP=chronic pelvic pain
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-surveillance-150120.pdf
October 01, 2014 - One review (Ching & Pringsheim, 2012) found
increased weight gain and higher risk ratios for
sedation … Notable side effects must be
considered, however, such as weight gain, sedation, drooling, and tremor … The most common AEs were sedation (26.5%),
somnolence (23.5%), headache (22.2%), and insomnia (13.6% … Eight patients (20.0%) experienced moderate to severe sedation and eight
(20.0%) experienced increased … For nearly all outcomes ratios for sedation and increased risk for weight regard to new evidence
and
-
effectivehealthcare.ahrq.gov/products/preoperative-testing/research-protocol
May 14, 2013 - any elective or ambulatory surgical or other invasive procedure that commonly requires anesthesia or sedation … team member; cataract surgery will be included regardless of local practice regarding anesthesia or sedation … surgeries)
Exclude patients undergoing nonsurgical diagnostic procedures that may require anesthesia or sedation … after routine preoperative testing in patients undergoing surgery or procedures requiring anesthesia or sedation … plan to explore differences across:
Types of and indications for surgery
Types of anesthesia or sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
July 01, 2022 - from
Surveillance Report 2 found
increased risk of WAEs and
nonsignificantly increased
risk of sedation … 95% CI,
1.88 to 5.34, I2=0%)
• Dizziness (28 RCTs): RR
2.85 (95% CI, 2.43 to
3.34, I2=36%)
• Sedation … THC/CBD associated with
large increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … 4.48 (95% CI, 2.77 to
7.22, I2=0%)
• Nausea (2 RCTs): RR
2.11 (95% CI, 1.20 to
3.72, I2=0%)
• Sedation … Gabapentin/pregabalin harms, sedation
Abbreviations: CI=confidence interval; CPP=chronic pelvic pain