-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-table-F5.xlsx
January 01, 2022 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-table-E-5.xlsx
January 01, 2023 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
May 19, 2020 - rate
• Blood pressure
• Objective measure of exercise capacity, e.g., 6-minute walk test
• Level of sedation … bicarbonate levels
• Heart rate
• Blood pressure
• Objective measure of exercise
capacity
• Level of sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
October 01, 2016 - psychiatrically ill, violently
agitated patients requiring chemical restraint produced
more rapid sedation … and greater sedation overall than
intramuscular lorazepam68 (one RCT, insufficient SOE). … other medication
protocols:
Benefits
(continued)
Change in
aggressive
behavior
(continued)
Sedation … Another RCT reported on acute extrapyramidal
events and incidence of marked sedation in a comparison … flunitrazepam at 90 minutes.48
Marked sedation
28
Insufficient Medium risk of
bias, consistency
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Computer-assisted system (Sedasys) for propofol sedation during
gastrointestinal endoscopy procedures … Computer-assisted system (Sedasys) for propofol sedation during gastrointestinal
endoscopy procedures … system intended
to aid clinicians in delivering propofol for minimal to moderate sedation during routine … The Sedasys sedation system is
intended to allow teams led by physicians who are not anesthesiologists … expressed views that
the Sedasys system does not address a significant unmet need because alternative sedation
-
effectivehealthcare.ahrq.gov/products/acs-depression/research-protocol
August 31, 2016 - Other risks: akathisia, restlessness, sedation, headache, nausea and vomiting
Olanzapine 6
For … safety alert: DRESS (drug reaction with eosinophilia and systemic symptoms)
FDA black box: delirium/sedation … syndrome with long acting injection (likely not relevant to use in depression)
Other risks: akathisia, sedation … Quetiapine 7
Yes, as an adjunct with an antidepressant
Other risks: sedation, hypertension, cataracts … but not limited to constipation, urinary retention and blurred vision) and CNS depression including sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
February 15, 2017 - Other risks: akathisia, restlessness, sedation,
headache, nausea and vomiting
Olanzapine6 For bipolar … safety alert: DRESS (drug reaction
with eosinophilia and systemic symptoms)
FDA black box: delirium/sedation … syndrome with long acting injection (likely
not relevant to use in depression)
Other risks: akathisia, sedation … Quetiapine7 Yes, as an
adjunct with an
antidepressant
Other risks: sedation, hypertension,
cataracts … but not limited to
constipation, urinary retention and blurred vision) and CNS depression including
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
December 01, 2010 - terms of extrapyramidal side effects and tardive dyskinesia, but produce other side
effects, including sedation … General: extrapyramidal side effects, weight gain, agitation, constipation,
sedation, elevated cholesterol … behaviors, death by suicide
General: extrapyramidal effects, weight
gain, agitation, constipation, sedation … • General adverse events: extrapyramidal effects, weight gain, agitation,
constipation, sedation,
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-repository-expanded-protocol.pdf
October 24, 2019 - Pharmacologic and Nonpharmacologic Treatments of Posttraumatic Stress Disorder
Evidence-based Practice Center Systematic Review Protocol
Project Title: Pharmacologic and Nonpharmacologic Treatments of Posttraumatic Stress
Disorder
I. Background and Objectives for the Systematic Review
Posttraumatic stress…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-repository-expanded-protocol.pdf
October 24, 2019 - Pharmacologic and Nonpharmacologic Treatments of Posttraumatic Stress Disorder
Evidence-based Practice Center Systematic Review Protocol
Project Title: Pharmacologic and Nonpharmacologic Treatments of Posttraumatic Stress
Disorder
I. Background and Objectives for the Systematic Review
Posttraumatic stress…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/draft-living-review-plant-chronic-pain-e-evidence-tables.xlsx
March 25, 2024 - (Numerator) Intervention A, N Analyzed for Sedation (Denominator) Intervention A, % With Sedation Intervention … B, N With Sedation (Numerator) Intervention B, N Analyzed for Sedation (Denominator) Intervention B … , % With Sedation Intervention C, N With Sedation (Numerator) Intervention C, N Analyzed for Sedation … (Denominator) Intervention C, % With Sedation Intervention D, N With Sedation (Numerator) Intervention … D, N Analyzed for Sedation (Denominator) Intervention D, % With Sedation Intervention A, N of Cannabis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-appendix-f1-f4-jan-2020.xlsx
January 01, 2020 - Events Serious Adverse Events Withdrawal Due to Adverse Events Dizziness Nausea Sedation … Intervention B, N Analyzed for nausea (denominator) Intervention B, % with nausea Intervention A, N of sedation … (numerator) Intervention A, N Analyzed for sedation (denominator) Intervention A, % with sedation Intervention … B, N of sedation (numerator) Intervention B, N Analyzed for sedation (denominator) Intervention B, … % with sedation Intervention A, N of Cannabis Use Disorder (numerator) Intervention A, N Analyzed for
-
effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
May 19, 2010 - that atypical antipsychotics can increase chances of adverse events such as significant weight gain, sedation … Neurological
Cerebrovascular accident (CVA)
Akathisia
Extrapyramidal Symptoms
Tardive Dyskinesia
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-off-label-update_research-protocol.pdf
May 19, 2010 - that atypical antipsychotics can increase chances of adverse events such as significant weight
gain, sedation … Source: www.effectivehealthcare.ahrq.gov
Published Online: May 19, 2010
Tardive Dyskinesia
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_executive.pdf
August 01, 2012 - Harms
or adverse effects reported in studies of antipsychotic
medications included sedation, gastrointestinal … depression.21,40,44 Adverse effects described in the study
of naltrexone included nausea, fatigue, sedation … in studies of SRIs included fatigue, tremor,
tachycardia, agitation, gastrointestinal complaints,
sedation … As in the case of efficacy, the data on adverse
effects associated with risperidone, including sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-annual-update2-appendices.pdf
January 16, 2023 - or disability,
including pain interferencea); harms and adverse
effects (e.g., dizziness, nausea, sedation … Sensitivity analysis of sedation for high-THC versus placebo (short term, 1 to 6 months followup) … Placebo
Sedation 6 RCTs
(N=866)1,2,4-7
Moderate Direct Consistent Imprecise Unknown Large effect … Placebo
Sedation 4 RCTs (N=335)9-
12
Moderate Direct Consistent Imprecise Unknown Moderate effect … Gabapentin
Alone)
Sedation 1 cohort study,
short- and
intermediate-term
(N=156)21
Moderate
-
effectivehealthcare.ahrq.gov/products/disruptive-behavior-disorder/clinician
August 31, 2016 - fairly immediate in nature:
Adverse events frequently reported with risperidone included weight gain, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_clinician.pdf
August 01, 2016 - immediate in nature:
�– Adverse events frequently reported with risperidone
included weight gain, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/draft-living-review-plant-chronic-pain-e-cohort-studies.xlsx
March 25, 2024 - C
Sedation
3 months: 31% (15/49) vs. 54% (28/52) vs. 33% (18/55), RR 0.57 (95% CI 0.35 to 0.93 for A … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/products/undescended-testicle/research-protocol
September 02, 2011 - Imaging approaches include magnetic resonance angiography, which requires sedation or anesthesia and … Need for further surgical intervention
Adverse effects, including but not limited to effects of sedation