-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1412.pdf
December 01, 2014 - using Sedasys to benzodiazepine/opiate-mediated sedation. … Endoscopist/nurse teams administered both sedation methods. … of propofol for sedation during endoscopies, experts also
commented. … compared with benzodiazepine/opioid
sedation. … An
assessment of computer-assisted personalized
sedation: a sedation delivery system to administer
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - Drug Assessment Time (Wk) Time Category WAE: n WAE: N SAE: n SAE: N Nausea: n Nausea: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Dry Mouth: n Dry Mouth: N N Randomized Dizziness: … : Specific AE Sedation: n Sedation: N N Randomized Dizziness: n Dizziness: N N Randomized Weight Gain … Randomized Dizziness: n Dizziness: N N Randomized Peripheral Edema: n Peripheral Edema: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Weight Gain: n Weight Gain: N N Randomized
Khasbage
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
June 01, 2014 - delivered using Sedasys to benzodiazepine/opiate-mediated sedation. … sedation during routine endoscopy procedures. … Endoscopist/nurse
teams administered both sedation methods. … compared with benzodiazepine/opioid sedation. … An assessment of computer-assisted personalized
sedation: a sedation delivery system to administer
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - Specific AE Cognitive Effects: n Cognitive Effects: N N Randomized Dry Mouth: n Dry Mouth: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Dizziness: n Dizziness: N N Randomized Weight Gain … Randomized Dizziness: n Dizziness: N N Randomized Peripheral Edema: n Peripheral Edema: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Weight Gain: n Weight Gain: N N Randomized
Lee, 2020
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - Specific AE Cognitive Effects: n Cognitive Effects: N N Randomized Dry Mouth: n Dry Mouth: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Dizziness: n Dizziness: N N Randomized Weight Gain … Randomized Dizziness: n Dizziness: N N Randomized Peripheral Edema: n Peripheral Edema: N N Randomized Sedation … : Specific AE Sedation: n Sedation: N N Randomized Weight Gain: n Weight Gain: N N Randomized
Khasbage
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
October 01, 2021 - There may be a large increased risk of dizziness and
sedation and a moderate increased risk of nausea … associated with moderate
improvement in pain severity, no effect on overall function and increased risk of
sedation … [SOE]a
Dizziness
Effect Size (N
Studies)
[SOE]a
Nausea
Effect Size (N
Studies)
[SOE]a
Sedation … the results with recent systematic reviews that used
the same methodology, suggests that the risk of sedation … were found with comparable THC to CBD
ratio oral sprays, with large increased risk of dizziness and sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-appendix-f-1_0.xlsx
January 01, 2016 - (etomidate-only) 24 Harms Aspiration ITT Technique/Device ETI: RSI vs. sedation-facilitated No cases … No medication Sedation-facilitated vs. … No medication Sedation-facilitated vs. … Sedation-facilitated RSI vs. … Sedation-facilitated RSI vs.
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apf2_0.xlsx
January 01, 2018 - SAE SAE Cognitive Effects Cognitive Effects Cognitive Effects Cognitive Effects Nausea Nausea Nausea Sedation … Sedation Sedation Sedation Serotonin Syndrome Serotonin Syndrome Serotonin Syndrome Serotonin Syndrome … , 2009 Fair LBP SNRI Duloxetine 120 mg/d 13 Short 27 112 3 112 Confusional state 0 112 NR 14 112 NR Sedation … Sedation Sedation Sedation Weight Gain Weight Gain Weight Gain
Author, Year Quality Pain Population … Sedation Sedation Sedation
Author, Year Quality Pain Population Drug Class Drug Assessment Time (wk
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - There may be a large increased
risk of dizziness and sedation and a moderate increased risk of nausea … high-THC to CBD) may be associated with small improvement in
pain severity, but with increased risk of sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … placebo, these interventions resulted in greater risk of common adverse
events (dizziness, nausea, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
February 01, 2008 - Potentiate
GABA
receptor
function
Absence
Atypical
Absence
Myoclonic
Neurological: ataxia,
sedation … and increase
GABA
availability
Partial
Lennox-
Gastaut
Neurological: insomnia,
dizziness, sedation … Tonic-
Clonic
Atypical
Absence
Myoclonic
Lennox-
Gastaut
Neurological: dizziness,
diplopia, sedation … Yes
Phenobarbital Potentiate
GABA
receptor
function
Partial
Tonic-
Clonic
Neurological: sedation … No
Tiagabine Increase
GABA
availability
Partial
Tonic-
Clonic
Neurological: confusion,
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0775-150722.pdf
May 12, 2015 - medications, such as Parkinsonism, akathisia, dystonia, and tardive dyskinesia), prolactin elevation,
sedation … medication (e.g., diabetes mellitus, extrapyramidal symptoms / tardive dyskinesia,
prolactin elevation, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - There may be a large increased risk of dizziness and sedation and a moderate
increased risk of nausea … high-THC to CBD) may be associated with moderate
improvement in pain severity, but with increased risk of sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … the results with recent systematic reviews
that used the same methodology, suggests that the risk of sedation … placebo, these interventions resulted in greater risk of common adverse events (dizziness,
nausea, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
January 01, 2025 - There may be a large increased risk of dizziness and
sedation (SOE: low) and a moderate increased risk … associated with small
improvement in pain severity (SOE: low), but with increased risk of WAEs (SOE:
low), sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … placebo, these interventions resulted in greater risk of common adverse
events (dizziness, nausea, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
May 29, 2025 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
May 29, 2025 - none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs. 23% (12/52) vs. 9% (5/55)
Sedation … 1.29 (95% CI 0.75 to 2.21)
Nausea: 16.7% (36/215) vs. 9.7% (21/216), RR 1.72 (95% CI 1.04 to 2.85)
Sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - There may be a large increased risk of dizziness and
sedation (SOE: low) and a moderate increased risk … associated with small
improvement in pain severity (SOE: low), but with increased risk of WAEs (SOE:
low), sedation … Studies)
[SOE]
Dizziness
Effect Size (N
Studies)
[SOE]
Nausea
Effect Size (N
Studies)
[SOE]
Sedation … placebo, these interventions resulted in greater risk of common adverse
events (dizziness, nausea, sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
April 01, 2021 - • Brexanolone probably improves depressive symptoms; it may increase the risk of
sedation or somnolence … in the third trimester or within 4 weeks
of birth, brexanolone may be associated with the risk of sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Consistent with prior
evidence, gabapentin was associated with increased risk of dizziness, sedation … in
cognitive AEs
• SOE: Low. based
on 8 RCTs
Large increase in
dizziness, peripheral
edema, sedation … (n=366) found
increased risk of
dizziness.6,7,9
1 RCT (n=306) found
increased risk of SAEs,
sedation … THC/CBD
associated with large
increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … SOE for large increase in risk for cognitive effects, moderate SOE for large increase in risk for
sedation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - Other common side effects are
dry mouth and sedation. … Patient-, parent- or care
impressions symptoms side effects provider-reported
outcomes
Depression Tics Sedation … difference.
sexual AE (1 RCT, 1 PCS)
Haloperidol vs. risperidone Low No significant difference.
(2 RCTs)
Sedation … SGA (continued)
Sedation Clozapine vs. olanzapine Low No significant difference.
(1 RCT, 1 PCS, 1 RCS … Sedation Aripiprazole vs. placebo (4 RCTs) Low Significant effect in favor of placebo
(RR = 2.7, 95%
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
July 01, 2022 - from
Surveillance Report 2 found
increased risk of WAEs and
nonsignificantly increased
risk of sedation … 95% CI,
1.88 to 5.34, I2=0%)
• Dizziness (28 RCTs): RR
2.85 (95% CI, 2.43 to
3.34, I2=36%)
• Sedation … THC/CBD associated with
large increase in WAEs,
dizziness, nausea, but no
increase in SAEs or
sedation … 4.48 (95% CI, 2.77 to
7.22, I2=0%)
• Nausea (2 RCTs): RR
2.11 (95% CI, 1.20 to
3.72, I2=0%)
• Sedation … Gabapentin/pregabalin harms, sedation
Abbreviations: CI=confidence interval; CPP=chronic pelvic pain